中国组织工程研究

中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (26): 4247-4252.doi: 10.3969/j.issn.2095-4344.0733

• 生物材料综述 biomaterial review • 上一篇    下一篇

控释纳米粒子在骨肿瘤化疗方面的应用

马鸿云1，2，庄新明1，考彦斌1，汪振宇1，曲志刚1，宋清旭1，许维国2，刘 一1   

  1. 1吉林大学第一医院脊柱外科，吉林省长春市 130021；2中国科学院长春应用化学研究所中科院生态环境高分子材料重点实验室，吉林省长春市 130022
  • 收稿日期:2018-02-09
  • 通讯作者: 刘一，教授，博士生导师，吉林大学第一医院脊柱外科，吉林省长春市 130021
  • 作者简介:马鸿云，男，1990年生，青海省西宁市人，汉族，吉林大学第一临床学院在读硕士，主要从事骨外科学、骨肿瘤、纳米载药及组织工程研究。
  • 基金资助:

    国家自然科学基金青年科学基金项目(51603204)

Application of controlled-release nanoparticles in chemotherapy of bone tumors

Ma Hong-yun1, 2, Zhuang Xin-ming1, Kao Yan-bin1, Wang Zhen-yu1, Qu Zhi-gang1, Song Qing-xu1, Xu Wei-guo2, Liu Yi1   

  1. 1Department of Spine, First Hospital of Jilin University, Changchun 130021, Jilin Province, China; 2Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin Province, China
  • Received:2018-02-09
  • Contact: Liu Yi, Professor, Doctoral supervisor, Department of Spine, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • About author:Ma Hong-yun, Master candidate, Department of Spine, First Hospital of Jilin University, Changchun 130021, Jilin Province, China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 51603204

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摘要：

文章快速阅读：

 

文题释义：
纳米粒子：是指粒度在1-100 nm之间的粒子，它们处于原子簇和宏观物体之间的过渡区，处于微观体系和宏观体系之间，是由数目不多的原子或分子组成的集团，因此它们既非典型的微观系统亦非典型的宏观系统。
控制释放给药系统：是通过物理、化学等方法，使药物在预定时间、按某一速度释放于特定的靶器官或靶组织，并使药物浓度较长时间维持在有效浓度内的一类制剂或装置。
 
 
背景：近年来，控释靶向纳米粒子在恶性肿瘤化疗方面得到越来越广泛的应用。
目的：综述控释靶向纳米粒子在骨肿瘤治疗方面的应用及其发展前景。

方法：以“Nanoparticles, controlled drug release, bone tumor or osteosarcoma or Ewing sarcoma”为关键词，检索PubMed、Web of Science、NCBI数据库中近十年来关于纳米控释靶向粒子在骨肿瘤治疗方面应用的最新进展。

结果与结论：骨肿瘤是一种具有较高发病率和死亡率的恶性肿瘤，严重威胁人类的健康。与传统化疗药物相比，纳米粒子具有控制释放，联合、协同治疗，跨越生物屏障，靶向治疗，增强肿瘤积累，延长循环时间等优势。控释靶向纳米粒子能针对骨肿瘤复杂的微环境实现靶向、精密调控，从而解决传统化疗所具有的不良反应和耐药性等问题。如何在保证载药率的同时提高纳米药物在肿瘤部位渗透效率、减少系统毒性、实现纳米药物治疗的多功能性是最终的研究目标。相信控释靶向纳米粒子以其固有的优势配合其智能、协同的载药方式，必将在这一交叉学科发挥更大的作用。

关键词: 纳米粒子, 控制药物释放, 药物呈递系统, 靶向治疗, 癌症, 骨肿瘤, 药物治疗, 化疗, 生物材料

Abstract:

BACKGROUND: In recent years, controlled-release nanoparticles have become popular in the treatment of malignant tumors.

OBJECTIVE: To summarize the applications and prospects of controlled-release nanoparticles in the treatment of bone tumors
METHODS: By using “nanoparticles, controlled drug release, bone tumor or osteosarcoma or Ewing sarcoma” as keywords, we retrieved PubMed, Web of Science and NCBI for the articles published in the past 10 years about the research progress of controlled-release nanoparticles in the treatment of bone tumors.

RESULTS AND CONCLUSION: Bone tumor is a malignant tumor with high morbidity and mortality, and seriously threatens the quality of life of human beings. Compared with traditional chemotherapeutic drugs, nanoparticles have the advantages of controlled release, synergistic treatment, crossing the biological barrier, targeted therapy, enhancing tumor accumulation and prolonging the circulation time. Controlled-release nanoparticles can target the complex microenvironment of bone tumors and enable targeting and precision control, which can minimize side effects and drug resistance of traditional chemotherapy. Our ultimate goal of research on controlled-release nanoparticles is to increase the penetration rate of nano-drugs at the tumor site and reduce the systemic toxicity while ensuring drug-loading rate, and to achieve the versatility of nano-drug treatments. We believe that the controlled-release nanoparticles with inherent advantages combined with intelligent and collaborative drug deliveries will play a considerable role in this interdisciplinary field.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Delayed-Action Preparations, Nanoparticles, Tissue Engineering

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