中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (43): 8049-8052.doi: 10.3969/j.issn.1673-8225.2010.43.018

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

电针刺激脊髓损伤患者穴位的脊髓磁共振功能成像激活区特征

陈业晞1，沈智威2，李志扬1，肖叶玉2，吴仁华2，孔抗美1   

  1. 汕头市汕头大学医学院第二附属医院，1外科，2放射科，广东省汕头市  515041
  • 出版日期:2010-10-22 发布日期:2010-10-22
  • 通讯作者: 吴仁华，教授，广东省汕头市汕头大学医学院第二附属医院放射科，广东省汕头市 515041 cjr.wurenhua@vip.163.com 孔抗美，教授，广东省汕头市汕头大学医学院第二附属医院外科，广东省汕头市 515041 kongkm@vip.sina.com
  • 作者简介:陈业晞☆，男，1970年生，广东省揭阳市人，汉族，2008年汕头大学医学院毕业，博士，主任医师，主要从事脊髓损伤机制及治疗研究。 chenyexi@vip.sina.com
  • 基金资助:

    广东省自然科学基金项目(815150 310200032)，广东省中医药管理局课题(2007369)，广东省卫生厅医学科研课题(A2007426，B2007130)立项支持。

Spinal cord functional MRI of patients with spinal cord injury following electrical stimulation at acupoints

Chen Ye-xi1, Shen Zhi-wei2, Li Zhi-yang1, Xiao Ye-yu2, Wu Ren-hua2, Kong Kang-mei1   

  1. 1 Department of Surgery, 2 Department of Radiology, Second Hospital of Shantou University Medical School, Shantou  515041, Guangdong Province, China
  • Online:2010-10-22 Published:2010-10-22
  • About author:Chen Ye-xi☆, Doctor, Chief physician, Department of Surgery, Second Hospital of Shantou University Medical School, Shantou 515041, Guangdong Province, China chenyexi@vip.sina.com
  • Supported by:

    the Natural Science Foundation of Guangdong Province, No. 815150 310200032*; a grant from Guangdong Administration of Traditional Chinese Medicine, No. 2007369*; the Medical Scientific Research Program of Guangdong Provincial Health Department, No.A2007426*, B2007130*

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摘要：

背景：研究发现脊髓功能激活区域和电生理等理论对应区域相一致，多数学者认为使用功能磁共振技术检测脊髓神经功能是可行的。
目的：检测电针刺激脊髓损伤患者的脊髓磁共振功能成像激活区特征，验证使用脊髓磁共振功能成像技术来客观评价针灸治疗脊髓损伤疗效的可行性。
方法：使用电针同时刺激3例脊髓损伤患者和5名健康志愿者的右手合谷穴和曲池穴，采用组块设计方法，使用SPM2软件得到患者和健康志愿者脊髓内真实的激活区，分析激活区在矢状位和横断位上的分布特征，并与健康志愿者的激活分布对比，找出患者的激活分布差异。
结果与结论：5名健康志愿者在脊柱C2 、C5段均重复出现激活信号，在C6段4名出现激活；3例脊髓损伤患者在脊柱C2，C6段均出现均重复出现激活，其中1例患者与健康志愿者激活分布特征基本一致。可以观察到针灸刺激脊髓损伤患者的脊髓功能激活，因此可以根据功能激活区的分布及强度，在一定程度上客观评价针灸治疗脊髓损伤的疗效。

关键词: 磁共振功能成像, 脊髓损伤, 针灸, 穴位, SEEP, 数字化图像与影像

Abstract:

BACKGROUND: Studies show that spinal cord function areas are consistent with electrophysiological theory related areas. Many researchers believe that it is feasible to detect spinal cord function by magnetic resonance imaging.
OBJECTIVE: To detect the characteristics of the spinal cord functional magnetic resonance imaging activated areas in patients with spinal cord injury using electrical stimulation to explore the feasibility of objective evaluating the effectiveness of acupuncture treatment of spinal cord injury using spinal magnetic resonance imaging technology.
METHODS: Hegu acupoint and Quchi acupoint in the right fore-arm of 3 patients with spinal cord injury and 5 healthy volunteers were stimulated by electrical acupuncture simultaneously. Based on the block design method, the true active areas within the spinal cord of patients and volunteers were acquired by the SPM2 software. The distribution characteristcs of actived areas in sagittal plane and in axial plane were analyzed. Compared with the actived areas of health volunteers, the differences of activated areas of SCI patients were found.
RESULTS AND CONCLUSION: For 5 healthy volunteers, there were activations in spinal C2 and C5 segments and four activation cases in the C6 segment. For patients, there was repeated activation in the spinal C2 and C6 segment. The activation distrubtion in one patient was similar to those of healthy volunteers. The spinal cord functional magnetic resonance imaging activation areas using the electrical simulation were observed. There were certain characteristics with the distribution of the activation. The efficacy of acupuncture treatment of spinal cord injury can be objectively evaluated, to a certain extent, by the distribution and intensity of activation of areas.

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