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Application of platelet-rich plasma combined with electrospun nanoscaffolds in bone and soft tissue
Zhao Mingyue, Yang Shun, Tu Xiling, Gao Li, Yang Kun, Liu Qi
2023, 27 (34):
5554-5560.
doi: 10.12307/2023.502
BACKGROUND: Both electrospinning and platelet-rich plasma have shown great application prospects in tissue regeneration and repair, but there are few studies on electrospun nanofiber composite scaffolds loaded with platelet-rich plasma.
OBJECTIVE: To review the research progress of electrospun nanofiber composite scaffolds loaded with platelet-rich plasma in bone and soft tissue engineering in recent years, in order to provide ideas and theoretical support for further in-depth research on the clinical application of composite scaffolds.
METHODS: Using “tissue engineering, platelet-rich plasma, electrospun scaffolds, stem cell, regenerative medicine” as English search terms and “tissue engineering, platelet-rich plasma, electrospinning, stem cell, tissue regeneration, bone regeneration, cartilage regeneration, soft tissue regeneration” as Chinese search terms, we searched PubMed, Web of Science, Ovid, SpringerLink, Wiley Oline Library, Medline, Wanfang, and CNKI databases. Totally 64 articles were finally included for review.
RESULTS AND CONCLUSION: (1) Electrospun nanoscaffolds loaded with platelet-rich plasma have the advantages of both platelet-rich plasma and electrospun nanoscaffolds, which are more elastic, less tearing, suitable mechanical strength and good biocompatibility. (2) The combination of platelet-rich plasma and three-dimensional oriented fiber scaffolds can better simulate the microenvironment of natural tissues, promote cell growth, proliferation and differentiation, and promote bone and soft tissue repair and regeneration. (3) In terms of bone tissue regeneration, it has certain compressive capacity under different stress conditions, and has good cell compatibility. (4) In terms of soft tissue regeneration, by regulating the porosity and surface area of the material, it is beneficial to cell respiration, and can promote wound healing, nerve cell growth and vascular regeneration. (5) However, due to various reasons, there are still few ideal materials that can be used in clinical practice to promote the regeneration and repair of bone and soft tissue. How to make use of the advantages of various materials and how to optimize the physical and chemical properties of various materials, so as to strengthen the interaction between scaffolds and seed cells, and maintain a high sustained-release effect on platelet-rich plasma-derived growth factor remains one of the problems to be solved in future research, which needs further in vivo research and clinical trials.
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