Research hot spots and trends of exosomes in theranostic application for chronic kidney disease

doi:10.12307/2023.765

Abstract

Abstract: BACKGROUND: To investigate the research focus and follow-up research trend of exosomes in the diagnosis and treatment of chronic kidney disease, in order to provide a corresponding reference basis for the future research of exosomes in the diagnosis and treatment of chronic kidney disease, and promote the development of this field.
OBJECTIVE: To conduct a bibliometric analysis of relevant studies in each database painstakingly until now for public publication on exosome diagnosis and treatment of chronic kidney disease, to explore the current state and trend of the field in this discipline, and to predict future research directions.
METHODS: A computerized search was performed on WanFang, CNKI, CBM, VIP, Web of Science, Cochrane Library, PubMed, and Embase databases from inception to December 2022 for published literature related to the diagnosis and treatment of chronic kidney disease by exosomes. The literature transcripts were screened by NoteExpress for co-occurrence, clustering and mutational analysis among authors, institutions, and keywords through CiteSpace 6.1R4 and VOSviewer software, and the visual knowledge map was plotted.
RESULTS AND CONCLUSION: (1) A total of 804 articles, including 133 in Chinese and 671 in English, were included, and the volume of publications climbed year by year with a rapid trend. We included 3 649 literature authors, including 326 Chinese authors and 3 323 English authors, and the field has formed a core team centered on scholars such as Liu Bicheng, Wang Bin, Lyu LinLi, Wang Xiaonan and Wang Haidong, and has formed a stable multicenter collaboration platform among institutions. Research focuses on the three functions of exosomes: carrier, diagnosis and therapy. (2) As a form of extracellular vesicles, exosomes have important mechanisms for carrying, transferring molecular mediators and signal transduction, and have an important role in the physiopathological development of chronic kidney disease, which can provide important health surveillance data for epidemiological studies and clinical decision-making. In recent years, the development of relevant studies on exosome-based diagnosis of chronic kidney disease has expanded dramatically, forming a development layout of collaborative cooperation among multiple institutions worldwide, led by our scientific research institutions. However, at present, the study of the specific function and mechanism of action of exosomes and contents in the disease process has not been fully validated. Their significance for the early diagnosis and prognosis evaluation of chronic kidney disease is not very clear. The intrinsic mechanism of action-related research is still relatively poor. Isolation and purification techniques still need to be improved, and high-quality evidence-based clinical trials with multicenter and large samples have not yet appeared, which still need to be verified by further studies.

Key words: chronic kidney disease, bibliometrics, knowledge mapping, visual analysis, exosome

CLC Number:

Chen Guanting, Zhang Linqi, Li Qingru. Research hot spots and trends of exosomes in theranostic application for chronic kidney disease[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(1): 86-92.

Figures/Tables 16

2.1 文献检索结果此次研究中文数据库共纳入文献406篇，其中CNKI数据库226篇、万方数据库132篇、维普网26篇、CBM数据库22篇；英文数据库共纳入文献1 030篇，其中Cochrane Library数据库12篇、Embase数据库414篇、PubMed数据库198篇、Web of Science数据库406篇，通过Citespace软件检索去重中文文献69篇、英文文献471篇，并按照纳入与排除标准，最终纳入中文文献133篇，英文文献671篇，共计804篇。 2.2 发文量分析外泌体诊疗慢性肾脏病相关研究文献英文数据库首发于1996年，中文数据库首发于2015年，对该领域发文量进行汇总，其年发文量通常可以在一定程度上反映学者的关注程度，而累积发文量则可判断目前所处研究阶段。如图2A所示，通过对年发文量进行统计，中英文文献数量总体呈现上升趋势，中国相关研究起步较晚，发文量较少。自2013年美国及德国科学家因发现并阐释细胞囊泡运输系统及其调控机制并获得诺贝尔生理学或医学奖后，外泌体相关研究迎来快速发展阶段，至2022年年均发文量英文文献约26篇，中文文献约19篇，2022-2023年因纳入文献不全且存在网络见刊及期刊见刊时间差异，故不做分析。累积发文量通常按照增长模型趋势分为4个阶段，即初始期、快速增长期、增长减缓期及饱和期 [11]。如图2B所示，英文文献自2013年，中文文献自2016年后便处于快速增长期，该阶段外泌体诊疗慢性肾脏病相关研究成果丰硕，尤其在基础研究方面受到科研人员的广泛关注。利用SPSS 23.0进行回归拟合，中英文文献均符合三次项函数增长，二者R2分别为0.997 2，0.968 8，均接近于1，意味着拟合程度较好，即外泌体诊疗慢性肾脏病相关研究仍会作为未来的研究热点，其文献量仍会保持较前快速增长的发展趋势。"

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