中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (32): 6047-6050.doi: 10.3969/j.issn.1673-8225.2011.32.036

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

神经干细胞转基因移植治疗帕金森病的可能与可行

丁继固   

  1. 咸宁学院基础医学院人体解剖学教研室，湖北省咸宁市  437100
  • 收稿日期:2011-03-09 修回日期:2011-04-28 出版日期:2011-08-06 发布日期:2011-08-06
  • 作者简介:丁继固，男，1954年生，湖北省咸宁市人，汉族，1977年咸宁学院毕业，教授，硕士生导师，主要从事神经解剖学和应用解剖学方面的研究。 dingjigu@hotmail.com
  • 基金资助:

    湖北省教育厅重点课题(D20092802)。

Transgenic neural stem cell transplantation for Parkinson’s disease: Possibility and feasibility

Ding Ji-gu   

  1. Human Anatomy Teaching, School of Basic Medicine, Xianning College, Xianning   437100, Hubei Province, China
  • Received:2011-03-09 Revised:2011-04-28 Online:2011-08-06 Published:2011-08-06
  • About author:Ding Ji-gu, Professor, Master’s supervisor, Human Anatomy Teaching, School of Basic Medicine, Xianning College, Xianning 437100, Hubei Province, China dingjigu@hotmail.com
  • Supported by:

    the Key Program of Department of Education of Hubei Province, No. D20092802*

PDF

440

被引次数

1

摘要：

背景：神经干细胞分化为何种类型的神经细胞，不仅取决于细胞自身基因调控，更受所处环境中外来信号的影响。
目的：就神经干细胞生物学特性、分化以及转基因移植治疗帕金森病的研究进展进行综述。
方法：由第一作者应用计算机检索PubMed数据库1992-01/2009-12及中国期刊网全文数据库2003-01/2010-12有关神经干细胞生物学特性、分化以及转基因移植治疗帕金森病的文章，英文检索词为“neural stem cell(NSCs), neural stem cell transplant, Parkinson’s disease(PD)”，中文检索词为“神经干细胞，干细胞移植，帕金森病”。排除重复性研究及Meta分析，共保留30篇文献进行综述。
结果与结论：转基因神经干细胞移植治疗帕金森病是目前公认的最有前景的治疗方案。在低氧条件下转基因培养的神经干细胞，能高效地诱导分化为多巴胺能神经元，为移植治疗帕金森病提供细胞源。但神经干细胞的生物学特性、诱导分化等还有待进一步分析。同时应用于人体治疗的生物安全性问题也逐渐引起人们的重视，如致瘤性等问题均在进一步探索中。

关键词: 神经干细胞, 干细胞移植, 转基因, 帕金森病, 多巴胺能神经元

Abstract:

BACKGROUND: Which type of nerve cells neural stem cells differentiate into is not only decided by cell own gene regulation, but also influenced by the external signals.
OBJECTIVE: To review the biology characteristics, differentiation and transgenic transplantation of neural stem cells in treatment of Parkinson’s disease.
METHODS: A computer search of PubMed (1992-01/2009-12) and CNKI (2003-01/2010-12) for articles related to the biology characteristics, differentiation and transgenic transplantation of neural stem cells in treatment of Parkinson’s disease was performed by the fist author using the keywords of “neural stem cells (NSCs), neural stem cell transplant, Parkinson's Disease (PD)” in English and Chinese, respectively. Finally, 30 articles were included.
RESULTS AND CONCLUSION: Treatment of Parkinson’s disease with transgenic transplantation of neural stem cells is the most promising treatment option. Under the low oxygen condition, neural stem cells receiving transgenic culture can be induced highly to differentiate into dopaminergic neurons that provide a cell source for treatment of Parkinson’s disease. However, the biological characteristics and induced differentiation of neural stem cells needs further studies. Simultaneously, the biological safety during human body treatment gradually attracts more attentions, such as oncogenicity that is studied further.

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