中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (3): 517-520.doi: 10.3969/j.issn.1673-8225.2010.03.033

• 生物材料综述 biomaterial review • 上一篇    下一篇

镍铬合金烤瓷牙的肾毒性：理论研究与临床验证

樊灿灿，宁  静，孟  松，李应龙，彭  鹏，刘  斌   

  1. 兰州大学口腔医院，甘肃省兰州市 730000
  • 出版日期:2010-01-15 发布日期:2010-01-15
  • 通讯作者: 刘 斌，博士，教授，兰州大学口腔医学院，甘肃省兰州市 730000 liubkq@lzu.edu.cn
  • 作者简介:樊灿灿，女，1990年生，湖北省随州市人，汉族，兰州大学口腔医学院在读本科生。 Fancc07@lzu.cn
  • 基金资助:

    兰州大学学生创新创业行动计划项目(2009-141)；兰州大学医学基金项目(LZUYX200625)。

Renal toxicity of dental porcelain crown containing Ni-Cr alloy: Theoretical study and clinical verification

Fan Can-can, Ning Jing, Meng Song, Li Ying-long, Peng Peng, Liu Bin   

  1. Stomatology Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China
  • Online:2010-01-15 Published:2010-01-15
  • Contact: Liu Bin, Doctor, Professor, Stomatology Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China liubkq@lzu.edu.cn
  • About author:Fan Can-can, Stomatology Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China Fancc07@lzu.cn
  • Supported by:

    Innovation and Pioneering Activities of Lanzhou University, No. 2009-141*; Medical Foundation of Lanzhou University, No. LZUYX200625*

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摘要：

背景：镍铬合金烤瓷牙是广泛应用于临床的修复体，对其安全性的争论通常限于口腔及邻近组织器官，而与全身范围内疾病如肾中毒的关联性尚未被重视。
目的：分析镍铬合金烤瓷牙导致肾病的可能性及长期应用临床的安全性。
方法：以“镍铬合金，烤瓷牙，肾中毒”为中文检索词，以“nickle chromium alloy，porcelain crown，nephridium toxicosis” 为英文检索词，采用计算机检索1989-01/2009-10维普中文科技期刊数据库、中国CNKI学术总库、万方数据库、中国生物医学文献数据库、Biosis Previews 数据库及BioOne生物全文期刊数据库相关文献。纳入与镍铬合金烤瓷牙及金属离子毒性相关研究，排除重复研究。
结果与结论：通过查阅国内外文献，文章从镍铬合金的腐蚀性及其在口腔和全身范围的蓄积和影响，镍铬烤瓷合金在体内所释放金属元素及其衍生物的直接毒性和肾中毒的易感性，以及镍铬离子造成肾脏损害的可能途径几方面分析了镍铬合金烤瓷牙的重金属离子腐蚀、扩散以及导致肾中毒的可能性，为进一步研究镍铬合金烤瓷牙的安全性提供依据。

关键词: 镍铬合金, 烤瓷牙, 肾中毒, 进展, 口腔生物材料

Abstract:

BACKGROUND: Dental porcelain crown containing Ni-Cr alloy has been widely used in modern dentistry. The dispute of its safety is limited in oral cavity and neighbor tissues, however, the relevance between Ni-Cr alloy and systemic disease, such as nephridium toxicosis, are poorly understood.
OBJECTIVE: To analyze the possibility of Ni-Cr porcelain crown resulted nephropathy and to explore its long-term clinical safety.
METHODS: Databases of VIP, CNKI, Wanfang, CBMdisc, Biosis Previews and BioOne were researched by computer with key words of “nickle chromium alloy, porcelain crown, nephridium toxicosis” both in Chinese and English. Literatures concerning Ni-Cr porcelain crown and toxicity of related metal ion were included, repetitive research was excluded.
RESULTS AND CONCLUSION: By consulting literatures, the possibility of erosion and release of heavy metal ion lead to nephridium toxicosis were analyzed with following aspects: effects of Ni-Cr alloy corrosivity and its accumulation on oral cavity or systemic disease; direct toxicity of released metal ions from Ni-Cr alloy and susceptivity of nephridium toxicosis; and the possible ways for renal damage resulted by Ni-Cr ion. This study can provide a basis for the further research concerning security of dental porcelain crown containing Ni-Cr alloy.

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