中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (2): 343-346.doi: 10.3969/j.issn.1673-8225.2011.02.038

• 组织构建综述 tissue construction review • 上一篇    下一篇

骨骼肌重塑中的钙调神经磷酸酶信号转导通路

贺  杰，漆正堂，丁树哲   

  1. 华东师范大学体育与健康学院，上海市  200241
  • 收稿日期:2010-07-22 修回日期:2010-08-17 出版日期:2011-01-08 发布日期:2011-01-08
  • 通讯作者: 丁树哲，教授，博士生导师，华东师范大学体育与健康学院，上海市 200241 szding@tyxx.ecnu.edu.cn
  • 作者简介:贺杰☆，女，1977年生，河南省南阳市人，华东师范大学在读博士，主要从事运动适应与健康研究。 hejieapple@163.com
  • 基金资助:

    课题受国家自然科学基金(30871212)，教育部新世纪优秀人才支持计划(790013P8)和上海市浦江人才计划(44038470)资助。

Effect of Calcineurin transduction pathway on skeletal muscle remodeling

He Jie, Qi Zheng-tang, Ding Shu-zhe   

  1. College of Physical Education & Health, East China Normal University, Shanghai 200241, China
  • Received:2010-07-22 Revised:2010-08-17 Online:2011-01-08 Published:2011-01-08
  • Contact: Ding Shu-zhe, Professor, Doctoral supervisor, College of Physical Education & Health, East China Normal University, Shanghai 200241, China szding@tyxx.ecnu.edu.cn
  • About author:He Jie☆, Studying for doctorate, College of Physical Education & Health, East China Normal University, Shanghai 200241, China hejieapple@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30871212; Program for New Century Excellent Talents in University, No. 790013P8; Pujiang Plan Program of Shanghai, No. 44038470

PDF

535

被引次数

3

摘要：

背景：骨骼肌重塑是骨骼肌对多种刺激因素所产生的形态结构与代谢机能的适应性变化。近几年关于钙调神经磷酸酶(CaN )/ (NFATS)在骨骼肌重塑中的作用备受关注。
目的：探讨钙调神经磷酸酶在骨骼肌从无氧转向有氧的代谢重塑、肌纤维类型转化以及在骨骼肌肥大过程中的信号转导作用。
方法：由第一作者用计算机检索ISI Web of knowledge数据库(1998/2010)，检索词为 “calcineurin，skeletal muscle，hypertrophy，NFAT，myofiber type”，语言设定为英文。从钙调神经磷酸酶信号系统在骨骼肌代谢、肌纤维类型转换和肌肉肥大中的作用方面进行总结，对其调节机制、肌肉重塑等方面进行介绍。
结果与结论：共检索到186篇文章，按纳入和排除标准对文献进行筛选，共纳入33篇文章。结果表明CaN/NFATS信号激活有助于Ⅰ型肌纤维分化，提高线粒体有氧代谢能力，但骨骼肌对耐力运动的适应并不绝对依赖CaN。CaN/NFATS转导通路有可能通过转录激活utrophin A来调控骨骼肌的肥大反应。由此可知钙调神经磷酸酶参与骨骼肌代谢、纤维转化和肥大的重塑过程，调节骨骼肌对刺激产生适应性应答反应。

关键词: 钙调神经磷酸酶, 骨骼肌, 肥大, 激活T细胞的核因子信号, 肌纤维类型, 组织构建

Abstract:

BACKGROUND: Skeletal muscle remodeling is an adaptive change of morphological structure and metabolic function to response to multiple stimuli. In the past years, the role of Calcineurin (CaN)/nuclear factor of activated T cells (NFAT) signaling has aroused increasing attention in skeletal muscle remodeling.
OBJECTIVE: To summarize and discuss the functions of CaN signaling transduction in metabolic remodeling from anaerobic metabolism to aerobic metabolism, myofiber type conversion, and skeletal muscle hypertrophy.
METHODS: A compute-based online search was performed by the first author ISI Web of knowledge database (1998/2010) with key words were “calcineurin, skeletal muscle, hypertrophy, NFAT, muscle fiber type” in English. The functions of CaN signaling transduction in metabolic remodeling were introduced from anaerobic metabolism to aerobic metabolism, myofiber type conversion, and skeletal muscle hypertrophy. 
RESULTS AND CONCLUSION: A total of 186 papers had been searched and 33 papers were chosen. The result shows that the activation of CaN/NFAT signaling contributes to the differentiation of myofiber type I and the improvement of aerobic metabolism and endurance, but not only CaN can improve the endurance. CaN/NFAT signaling transduction pathway may regulate skeletal muscle hypertrophy by the activation of utrophin A. Accordingly, calcineurin plays a role in skeletal muscle metabolism, fiber transformation, and hypertrophic remodeling, and modulates adaptive response to stimuli.

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