中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (26): 4242-4251.doi: 10.12307/2022.830

• 组织构建综述 tissue construction review • 上一篇    下一篇

肿瘤坏死因子α在牙槽骨改建中的骨免疫学效应

宫雨晴,姚  蔚,李  然   

  1. 山西医科大学口腔医学院·口腔医院,口腔疾病防治与新材料山西省重点实验室,山西省太原市  030001
  • 收稿日期:2021-10-08 接受日期:2021-11-13 出版日期:2022-09-18 发布日期:2022-03-09
  • 通讯作者: 姚蔚,博士,副主任医师,硕士生导师,山西医科大学口腔医学院·口腔医院,口腔疾病防治与新材料山西省重点实验室,山西省太原市 030001 李然,博士,副教授,硕士生导师,山西医科大学口腔医院医务科主任,山西医科大学口腔医学院·口腔医院,口腔疾病防治与新材料山西省重点实验室,山西省太原市 030001
  • 作者简介:宫雨晴,女,1995年生,河北省沧州市人,汉族,山西医科大学口腔临床医学专业在读硕士,主要从事牙槽骨改建方面的研究。
  • 基金资助:
    山西省高等学校科技创新项目(2019L0443),项目负责人:姚蔚;山西省自然科学基金——面上自然基金项目(201701D121144),项目负责人:姚蔚

Osteoimmunological effect of tumor necrosis factor alpha in alveolar bone remodeling

Gong Yuqing, Yao Wei, Li Ran   

  1. Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi Province, China
  • Received:2021-10-08 Accepted:2021-11-13 Online:2022-09-18 Published:2022-03-09
  • Contact: Yao Wei, MD, Associate chief physician, Master’s supervisor, Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi Province, China Li Ran, MD, Associate professor, Master’s supervisor, Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi Province, China
  • About author:Gong Yuqing, Master candidate, Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi Province, China
  • Supported by:
    the Scientific and Technological Innovation Program of Higher Education Institutions in Shanxi Province, No. 2019L0443 (to YW); the Natural Science Foundation of Shanxi Province (General Program), No. 201701D121144 (to YW)

摘要:

文题释义:
肿瘤坏死因子α:是一种主要由巨噬细胞和单核细胞产生的促炎细胞因子,参与正常的炎症反应和免疫反应,并且在骨病理生理学中起着核心作用。此外,它还可以直接杀伤肿瘤细胞,在许多病理状态下表达增多。
骨免疫学:骨免疫学概念由Arron和Choi于2000年首次提出,将免疫系统和骨骼系统紧密联系在一起,是研究在生理和病理条件下免疫系统和骨骼系统共享的分子以及这2系统在细胞和分子水平上的直接对话、相互作用及其作用机制的一门学科。

背景:骨免疫学强调了骨骼系统和免疫系统之间密不可分的联系,它的兴起给牙槽骨改建相关疾病的治疗提供了新的研究思路,而肿瘤坏死因子α是骨免疫学中一种重要的细胞因子,参与骨关节炎、慢性牙周炎等疾病以及正畸牙齿移动的骨代谢及骨改建。
目的:阐述了肿瘤坏死因子α在牙槽骨改建过程中的骨免疫调节作用及其研究进展。
方法:检索PubMed、万方及中国知网数据库收录的肿瘤坏死因子α和骨改建及骨免疫学研究相关的文献,最终纳入76篇文献进行归纳总结。
结果与讨论:①牙槽骨是机体骨改建最活跃的部分,牙槽骨改建常见于正畸治疗、牙周炎以及种植体的骨结合过程。②肿瘤坏死因子α对牙槽骨改建的骨免疫学效应表现在高浓度的肿瘤坏死因子α主要通过核转录因子κB通路促进破骨基因如核转录因子κB受体活化因子配体的表达,促进破骨细胞的成熟分化引起骨吸收;③早期低浓度的肿瘤坏死因子α则通过核转录因子κB通路调节Wnt/β-连环蛋白和骨形态发生蛋白等通路间接促进成骨基因如骨钙素的表达,促进成骨细胞的成熟分化引起新骨形成。④因此肿瘤坏死因子α是调节牙槽骨改建的关键细胞因子之一,且在该过程的分子机制网络中起着核心的作用。⑤肿瘤坏死因子α的调节具有双向性,体内微环境又复杂,如何控制肿瘤坏死因子α的调节作用是一大难题。⑥文章希望为临床上正畸、牙周炎和种植治疗过程中监控肿瘤坏死因子α浓度并即时反馈,防止医源性牙槽骨过度吸收提供新的研究方向和理论基础。

https://orcid.org/0000-0002-6715-7657 (宫雨晴);https://orcid.org/0000-0002-7389-8873 (姚蔚) ;https://orcid.org/0000-0002-0647-2557 (李然)

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: 肿瘤坏死因子α, 核转录因子κB, 骨免疫, 成骨细胞, 破骨细胞, 牙周炎, 牙槽骨改建, 骨结合

Abstract: BACKGROUND: Osteoimmunology emphasizes the inseparable relationship between skeletal system and immune system, and its rise provides a new research direction for the treatment of alveolar bone remodeling related diseases. Tumor necrosis factor-α is an important cytokine in osteoimmunology, which participates in bone metabolism and bone remodeling related to osteoarthritis, chronic periodontitis and orthodontic tooth movement.
OBJECTIVE: To review the osteoimmunological effect of tumor necrosis factor-α during alveolar bone remodeling and the latest progress.
METHODS: The literatures related to tumor necrosis factor-α, bone remodeling, osteoimmunology were searched in PubMed, WanFang and CNKI databases, and finally 76 articles were included and summarized.
RESULTS AND CONCLUSION: Alveolar bone is the most active part of bone remodeling, and alveolar bone remodeling is common in orthodontic treatment, periodontitis treatment and osseointegration of implants. The osteoimmunological effect of tumor necrosis factor-α on alveolar bone remodeling is that high concentration of tumor necrosis factor-α mainly promotes the expression of osteoclast genes such as nuclear factor κB receptor activator ligand through nuclear factor kappa-B signaling pathway, thus promoting the maturation and differentiation of osteoclasts leading to bone resorption. In the early stage, low concentration of tumor necrosis factor-α indirectly promotes the expression of osteogenic genes such as osteocalcin by activating Wnt/β-catenin and bone morphogenetic protein signaling pathways through the nuclear factor-κB pathway, which subsequently promotes osteoblast maturation and differentiation and leads to new bone formation. Therefore, tumor necrosis factor-α is one of the key cytokines regulating alveolar bone remodeling and plays a core role in the molecular mechanism network of this process. Tumor necrosis factor-α has a bi-directional regulatory role and the microenvironment in vivo is complex, so how to control the regulation of tumor necrosis factor-α is a difficult problem. This review may be expected to provide a new research direction and theoretical basis for monitoring the concentration of tumor necrosis factor-α and immediate feedback in clinical orthodontics, periodontitis and implant treatments to prevent iatrogenic alveolar bone resorption.

Key words: tumor necrosis factor-α, nuclear factor-κB, osteoimmunology, osteoblast, osteoclast, periodontitis, alveolar bone remodeling, osseointegration

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