中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (34): 5463-5467.doi: 10.3969/j.issn.2095-4344.2015.34.011

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

纳米羟基磷灰石复合聚酰胺66材料修复早期股骨头坏死

杨明敏1，李 黛2，孙 扬1   

  1. 1新疆医科大学第一附属医院，新疆维吾尔自治区乌鲁木齐市  830011； 2解放军第二军医大学附属长海医院麻醉疼痛中心，上海市  200433
  • 出版日期:2015-08-20 发布日期:2015-08-20
  • 通讯作者: 孙扬，硕士，主治医师，新疆医科大学第一附属医院，新疆维吾尔自治区乌鲁木齐市 830011
  • 作者简介:杨明敏，男，1984年生，回族，江苏省启东市人，2015年新疆医科大学毕业，硕士，医师，主要从事骨与关节置换及术后疼痛康复方面的研究。 并列第一作者：李黛，女，1987年生，汉族，河北省枣强市人，2015年中山大学毕业，博士，医师，主要从事病理性疼痛的机制及治疗研究。

Nano-hydroxyapatite/polyamide 66 composite for repair of early femoral head necrosis 

Yang Ming-min1, Li Dai2, Sun Yang1   

  1. 1First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 2Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Online:2015-08-20 Published:2015-08-20
  • Contact: Sun Yang, Master, Attending physician, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
  • About author:Yang Ming-min, Master, Physician, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China Li Dai, M.D., Physician, Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China Yang Ming-min and Li Dai contributed equally to this work.

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296

被引次数

2

摘要：

背景：纳米羟基磷灰石复合聚酰胺66材料具有良好的材料-细胞界面，拥有三维孔洞网络结构，在植入人体后还可以随着时间的推移逐渐降解。

目的：观察纳米羟基磷灰石复合聚酰胺66材料修复早期股骨头坏死的效果。

方法：纳入62例早期股骨头坏死患者，其中男32例，女30例，年龄34-51岁，均分为2组治疗，观察组进行纳米羟基磷灰石复合聚酰胺66材料植入联合髓芯减压植骨治疗，对照组进行钽棒置入联合髓芯减压植骨治疗。对比两组治疗后1 d疼痛情况，治疗后随访12个月，对比两组髋关节功能Harris评分。

结果与结论：治疗后1 d，两组疼痛目测类比评分比较差异无显著性意义。观察组治疗后3，12个月的髋关节功能Harris评分高于对照组(P < 0.05)，两组均未发生与修复材料相关的不良反应。表明利用纳米羟基磷灰石复合聚酰胺66材料修复早期股骨头坏死具有良好的生物相容性，并可促进患者肢体功能恢复。

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 生物材料, 纳米材料, 纳米羟基磷灰石, 聚酰胺66, 股骨头坏死, 修复, 骨移植, 髓芯减压

Abstract:

BACKGROUND: Nano-hydroxyapatite/polyamide 66 composite has good material-cell interface and three-dimensional porous network structure, and it can also be gradually degraded over time after implantation in the human body.

OBJECTIVE: To explore the effect of nano-hydroxyapatite/polyamide 66 in early repair of femoral head necrosis.

METHODS: A retrospective analysis was performed on clinical data of 62 cases of early osteonecrosis of the femoral head, including 32 males and 30 females, aged 34-51 years. These patients were divided into control group (31 cases) and observation group (31 cases) according to treatment methods. Core decompression with nano-hydroxyapatite/polyamide 66 implantation and core decompression with bone graft were respectively performed in the observation and control groups. Incidence of pain in the two groups was compared at 1 day after treatmen; and during the 12-month follow-up, the Harris score of the hip function in the two groups was compared.

RESULTS AND CONCLUSION: There was no significant difference in the visual analog scale scores between two groups at 1 day after treatment. The Harris scores in the observation group were significantly higher than those in the control group at 3 and 12 months after treatment (P < 0.05). There was no adverse reaction in the two groups. These findings indicate that nano-hydroxyapatite/polyamide 66 material for repair of early femoral head necrosis has good biocompatibility, and can obtain good effects on limb function recovery.

Key words: Hydroxyapatites, Nylons, Femur Head Necrosis

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