中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (24): 3778-3782.doi: 10.3969/j.issn.2095-4344.2015.24.002

• 骨组织构建 bone tissue construction • 上一篇    下一篇

胰岛素样因子、睾酮及骨代谢指标预测老年男性骨质疏松性骨折的意义

刘宣民   

  1. 博兴县人民医院外二科,山东省滨州市  256500
  • 出版日期:2015-06-11 发布日期:2015-06-11
  • 作者简介:刘宣民,男,1968年生,1992年潍坊医学院临床医学专业毕业,副主任医师,主要从事骨科创伤与显微外科研究。

Insulin-like factor, testosterone and bone metabolism indexes in the prediction of osteoporotic fractures in elderly men  

Liu Xuan-min   

  1. Second Department of General Surgery, People’s Hospital of Boxing County, Binzhou 256500, Shandong Province, China
  • Online:2015-06-11 Published:2015-06-11
  • About author:Liu Xuan-min, Associate chief physician, Second Department of General Surgery, People’s Hospital of Boxing County, Binzhou 256500, Shandong Province, China

摘要:

背景:老年男性骨质疏松的发病率随着国内人口老龄化趋势的加剧逐年提升,骨质疏松患者容易发生骨折,对患者的生命安全造成严重威胁,但目前临床上仍缺少有效的筛选措施预防骨质疏松的发生。
目的:探究胰岛素样因子、睾酮及骨代谢指标水平在预测老年男性骨质疏松性骨折中的临床意义。
方法:选取骨质疏松症男性患者120例作为观察组,另选择同时期收治的非骨质疏松症体检健康的男性人群120例作为对照组,两组受试者在年龄及体质量指数等方面比较差异无显著性意义,具有可比性。对两组受试者抽血检测胰岛素样因子、血清睾酮及骨代谢指标的水平。
结果与结论:观察组患者腰椎侧位骨密度和左股骨颈骨密度均显著低于对照组(P < 0.05);观察组患者血液中胰岛素样因子和血清睾酮水平显著低于对照组(P < 0.05);观察组患者Ⅰ型胶原C端异物肽和Ⅰ型胶原羧基端肽β特殊序列(β-CTX)水平也显著高于对照组(P < 0.05);两组患者骨钙素(BGP)、血清钙、血清磷水平相比差异无显著意义(P > 0.05)。结果提示,通过检测老年男性血清中睾酮、胰岛素样因子及部分骨代谢指标的水平,可早期预测骨密度,为筛查老年男性骨质疏松症的高危状态起到一定的预测作用,具有一定的参考价值。

 中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

关键词: 组织构建, 骨组织工程, 骨密度, 睾酮, 骨代谢指标, 老年男性, 骨密度, 睾酮性骨折

Abstract:

BACKGROUND: The domestic incidence of osteoporosis in elderly men has an increasing trend with aging. Osteoporosis patients are prone to fracture, which can pose a serious threat to patient’s life and safty, but there is still a lack of effective screening measures to prevent its occurrence.
OBJECTIVE: To explore the clinical significance of insulin-like factor, testosterone and bone metabolism index levels in the prediction of osteoporotic fracture in elderly men. METHODS: Totally 120 male patients with osteoporotic fractures were enrolled as observation group, and another 120 healthy males with no osteoporosis admitted at the same period acted as controls. There were no differences in age and body mass index between the two groups. Insulin-like factor, testosterone and bone metabolism index levels were detected and compared between the two groups.
RESULTS AND CONCLUSION: Compared with the control group, the bone mineral densities of the lumbar vertebrae and left femoral neck were significantly lower in the observation group (P < 0.05), and the levels of insulin-like factor and serum testosterone were also significantly lower in the observation group (P < 0.05), but the levels of collagen type I C-terminal foreign bodies and β-CTX were significantly higher in the observation group. No significance was found in the osteocalcin, serum calcium, serum phosphorus levels between the two groups (P > 0.05). These findings suggest that the serum testosterone, insulin-like factor and some bone metabolism indexes can be used for prediction of osteoporotic fractures in elderly men, which have a certain reference value. 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Bone Density, Testosterone, Osteoporosis

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