中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (26): 6916-6922.doi: 10.12307/2026.827

• 生物材料综述 biomaterial review • 上一篇    下一篇

硒对人体骨健康影响及在骨材料中的应用

叶高祺，龚玉康，陈德金，高文山   

  1. 河北大学附属医院骨科，河北省保定市  071000
  • 接受日期:2025-12-31 出版日期:2026-09-18 发布日期:2026-03-16
  • 通讯作者: 高文山，博士，主任医师，教授，博士生导师，河北大学附属医院骨科，河北省保定市 071000
  • 作者简介:叶高祺，男，1999年生，广东省河源市人，汉族，河北大学在读硕士，主要从事人工骨修复材料方向的研究。
  • 基金资助:
    河北大学附属医院2024年院内基金项目(2024ZA01)，项目负责人：高文山

Selenium effect on human bone health and its application in bone materials

Ye Gaoqi, Gong Yukang, Chen Dejin, Gao Wenshan   

  1. Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
  • Accepted:2025-12-31 Online:2026-09-18 Published:2026-03-16
  • Contact: Gao Wenshan, MD, Chief physician, Professor, Doctoral supervisor, Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
  • About author:Ye Gaoqi, MS candidate, Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
  • Supported by:
    2024 In-Hospital Fund Project of Affiliated Hospital of Hebei University, No. 2024ZA01 (to GWS) 

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摘要：

文题释义：
硒：是一种存在于动植物等生物体内的微量元素，因抗炎、抗氧化和促成骨等性能引起了各行各业的广泛关注，但因毒性大等问题限制了其生物应用。 
骨材料：是修复骨组织的人工生物材料，主要通过骨生成、骨传导和骨诱导发挥作用。骨材料按材料性质可分为无机、有机和复合材料三类：无机材料以羟基磷灰石、磷酸钙陶瓷为主，具有与天然骨相近的化学成分；有机材料包括胶原、聚乳酸等高分子，侧重骨诱导特性；复合材料结合两者优势，通过结构复合提升力学强度与生物活性。

背景：近年来，硒改性骨修复材料在骨疾病和骨再生修复治疗中展现了巨大的应用前景。
目的：总结不同类型硒改性骨修复材料的构建方式及调控骨再生免疫微环境的效果、作用机制和促进骨再生修复的作用。
方法：检索中国知网、万方、PubMed和ScienceDirect数据库建库至2025年发表的文献，中文检索词为“硒，骨缺损，骨质疏松，大骨节病，骨肉瘤”，英文检索词为“Selenium，bone defect，osteoporosis，osteoarthritis，Kashin Beck disease，osteosarcoma”。通过阅读文献进行初筛，排除重复及内容不相关的文献，最终纳入64篇文献进行综述。
结果与结论：硒具有抗炎、抗氧化和促成骨等特性，可有效改善骨的免疫微环境。虽然硒的毒性大，但将硒引入到骨材料中可有效降低硒的毒性，硒在骨修复材料中常用的引入模式有介孔粒子、纳米粒子、氢键、共价键(二硒键)等。在复合材料中，硒通过发挥抗氧化、抗炎能力和调节免疫微环境和促进成骨基因表达，为骨缺损修复再生构建了理想的微环境；通过抗凋亡、促进软骨细胞自我更新以及调节细胞微环境，为治疗大骨节病提供潜在的方向；可改善软骨细胞的周围环境，通过抗凋亡、抗氧化、抗衰老、增强软骨的合成代谢，为治疗骨关节炎提供了新的视角。但目前大部分研究停留在较为基础层面，距离应用于临床尚有许多挑战。
https://orcid.org/0009-0002-8471-4280(叶高祺)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 硒, 骨材料, 骨修复, 骨病, 免疫微环境, 活性氧, 骨, 工程化骨材料

Abstract: BACKGROUND: In recent years, selenium modified bone repair materials have shown great potential in the treatment of bone diseases and regenerative repair.
OBJECTIVE: To summarize the construction strategies of different types of selenium modified bone repair materials, as well as the effects, mechanisms, and repair promoting effects of regulating the immune microenvironment of bone regeneration.
METHODS: CNKI, WanFang, PubMed, and ScienceDirect databases were searched for literature published from database inception to 2025, using the Chinese search terms “selenium, bone defect, osteoporosis, Kashin Beck disease, osteosarcoma” and English search terms “selenium, bone defect, osteoporosis, osteoarthritis, Kashin Beck disease, osteosarcoma.” By reading literature for initial screening, duplicate and irrelevant articles were excluded, and ultimately 64 articles were included for review.
RESULTS AND CONCLUSION: Selenium has anti-inflammatory, antioxidant, and bone promoting properties, which can effectively improve the immune microenvironment for bone regeneration. Selenium has high toxicity, but introducing selenium into bone materials can effectively diminish the toxicity of selenium. Selenium is often incorporated into bone repair materials using methods like mesoporous particles, nanoparticles, hydrogen bonds, and covalent bonds (diselenoses). In composite materials, selenium uses its antioxidant and anti-inflammatory properties to regulate the immune environment and encourage osteogenic gene expression. This creates a favorable environment for bone defect repair and regeneration. Selenium also shows promise for treating Kashin-Beck disease by preventing cell death, promoting chondrocyte renewal, and regulating the cellular environment. Furthermore, by preventing cell death, acting as an antioxidant, slowing aging, and boosting cartilage synthesis, it can improve the environment around chondrocytes, offering a new approach to treating osteoarthritis. However, much of the research is currently still in early stages, and significant challenges must be addressed before it can be used clinically.


Key words: selenium, bone material, bone repair, bone disease, immune microenvironment, reactive oxygen species, bone, engineered bone materials

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