中国组织工程研究

• 组织构建综述 tissue construction review • 上一篇    下一篇

基于文献计量学分析代谢组学在中医证型研究领域的应用

何  静1,孙志岭1,谢  彤2,焦文娟1,张永怡1   

  1. 1南京中医药大学护理学院,江苏省南京市  210000;2南京中医药大学中医儿科学研究所,江苏省南京市  210000
  • 收稿日期:2018-02-24 出版日期:2018-06-08 发布日期:2018-06-08
  • 通讯作者: 孙志岭,博士,教授,南京中医药大学护理学院,江苏省南京市 210000
  • 作者简介:何静,女,1993年生,江苏省淮安市人,汉族,南京中医药大学在读硕士,主要从事代谢组学研究。
  • 基金资助:

    国家自然科学基金面上项目(81774383);江苏省普通高校学术学位研究生科研创新计划项目(KYLX16-1164)

Metabolomics applied in Chinese medicine syndromes: a bibliometric analysis

He Jing1, Sun Zhi-ling1, Xie Tong2, Jiao Wen-juan1, Zhang Yong-yi1   

  1. 1College of Nursing, 2Institute of Chinese Medicine for Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
  • Received:2018-02-24 Online:2018-06-08 Published:2018-06-08
  • Contact: Sun Zhi-ling, M.D., Professor, College of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
  • About author:He Jing, Master candidate, College of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
  • Supported by:

    the National Natural Science Foundation of China (General Program), No. 81774383; the Research Innovation Project for the Academic Postgraduates in Colleges of Jiangsu Province, No. KYLX16-1164

摘要:

文章快速阅读:
文题释义
文献计量学:是指用数学和统计学的方法,定量地分析一切知识载体的交叉科学。它是集数学、统计学、文献学为一体,注重量化的综合性知识体系。其计量对象主要是:文献量各种出版物(尤以期刊论文和引文居多)、作者数(个人集体或团体)、词汇数各种文献标识(其中以叙词居多)。文献计量学最本质的特征在于其输出务必是“量”。
中医证型:是中医所特有的一种名称。证,既证候,是指疾病发展过程中某一个阶段的病理属性的概括。中医将人体分为阴阳气血,又将病因分为风寒暑湿燥热痰及虚实等。证型就是由不同的病因引起阴阳气血的不同变化导致人体的不同疾病状态。
摘要
背景:
代谢组学是以组群指标分析为基础,以高通量检测和数据处理为手段,以信息建模和系统整合为目标的系统生物学分支,其方法适用于识别代谢指标,可以为个体化诊疗、诊断提供依据,更好指导临床辨证论治。
目的:分析建库至今以来代谢组学在中医证型研究领域应用的文献特征和研究现状,为该组学技术在中医证型研究领域的应用提供借鉴。
方法:以中国知网、万方数据库、中国生物医学文献数据库、PubMed、Web of science、Medline数据库为资料来源,检索建库至2017年6月收录的中医证型研究领域应用代谢组学的文献,建立文献数据库,采用文献计量学及数据挖掘的方法,对其文献特征及研究特征进行统计分析。
结果与结论:①纳入499篇,期刊文献371篇(74.35%),会议论文30篇(6.01%),学位论文98篇(19.64%)。371篇关于代谢组学在中医证型研究领域应用的期刊文献共分布在124种期刊上,其中中文核心期刊32种,占总文献量的45.28%;SCI收录期刊10种,占总文献量的3.77%;②根据文献内容统计分类得到7类病症系统(以消化系统和循环系统为主),涉及23种疾病,39种干预措施;③中医证型研究领域应用代谢组学技术辨证分型的统一化、标准化仍有待提高,同时文献的质量也相对欠缺。应加强提高动物实验类研究的质量,探讨疾病证型本质及干预措施机制,以期控制疾病的发生发展。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0002-5582-4344(何静)

关键词: 代谢组学, 中医证型, 文献计量学, 组织构建

Abstract:

BACKGROUND: Metabolomics is a branch of systems biology taking systematic study, high-throughput detection and data processing as means, information modeling and systematic integration as targets, which can be used for recognizing metabolic indexes, provide evidence for individualized diagnosis and treatment and guide syndrome differentiation in the clinic.
OBJECTIVE: To analyze the literature features and research status of metabolomics applied in the field of Chinese medicine syndromes so as to provide reference for its application in Chinese medicine syndromes.
METHODS: Databases of CNKI, WanFang, CBM, PubMed, Web of Science and Medline were retrieved for the articles addressing metabolomics applied in Chinese medicine syndromes published before June 2017. The literature database was established, and then the literature and research features were analyzed using bibliometrics and data mining.
RESULTS AND CONCLUSION: Totally 499 articles were enrolled, including 371 journal articles from journals (74.35%), 30 conference papers (6.01), 98 dissertations (19.64), and the 371 journal papers were published in 124 journals (32 of Chinese core journals (45.28%), and 10 SCI cited journals (3.77%)). In the articles, 7 types of disease systems (mainly in digestive system and circulatory system) were classified according to the statistics, involving 23 diseases and 39 interventions. In summary, there is still a lack of standardized classification for metabolomics applied in Chinese medicine syndromes and the quality of literature is poor. We should conduct more animal experiments and explore the essence and intervention measurements of syndromes, thereby controlling the disease occurrence and development.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Metabolism, Proteomics, Medicine, Chinese Traditional, Bibliometrics, Tissue Engineering

中图分类号: