中国组织工程研究

中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (30): 4867-4872.doi: 10.3969/j.issn.2095-4344.2017.30.019

• 药物控释材料 drug delivery materials • 上一篇    下一篇

细菌纤维素/聚乙烯醇/聚丙烯酰胺复合水凝胶的性能表征

马  骉1，董炎炎2，陈世文3
  

  1. 1山东省曹县人民医院急诊科，山东省曹县  274400；2上海应用技术大学生物工程系，上海市  200235；3上海交通大学附属第六人民医院神经外科，上海市  200235
  • 收稿日期:2017-05-14 出版日期:2017-10-28 发布日期:2017-11-07
  • 通讯作者: 陈世文，博士，主任医师，上海交通大学附属第六人民医院神经外科，上海市 200235
  • 作者简介:马骉，男，1978年生，山东省单县人，汉族，2010年延边大学毕业，主治医师，主要从事急危重症的临床和基础研究。
  • 基金资助:
    上海交通大学医工交叉基金(YG2012MS34)

Performance characterization of bacterial cellulose reinforced polyvinyl alcohol/ polyacrylamide composite hydrogels

Ma Biao1, Dong Yan-yan2, Chen Shi-wen3 
  

  1. 1Department of Emergency, Caoxian People’s Hospital, Caoxian 274400, Shandong Province, China; 2Department of Bioengineering, Shanghai Institute of Technology, Shanghai 201418, China; 3Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200235, China
  • Received:2017-05-14 Online:2017-10-28 Published:2017-11-07
  • Contact: Chen Shi-wen, M.D., Chief physician, Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200235, China
  • About author:Ma Biao, Attending physician, Department of Emergency, Caoxian People’s Hospital, Caoxian 274400, Shandong Province, China
  • Supported by:
    the Medicine Engineering Cross Fund of Shanghai Jian Tong University, No. YG2012MS34

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摘要：

文章快速阅读：

 

文题释义：
复合水凝胶：水凝胶作为高吸水材料、外科软组织填充材料、软性角膜接触镜和皮肤移植材料等在卫生、生物医学、建筑、化工等诸多领域得到广泛的应用。一般水凝胶由化学交联的聚电解质构成，其断裂通常在10-100 J/m2范围内，所以降低了实际应用范围。但如果通过向交联的水凝胶中加入其他聚合物，如聚乙烯醇、细菌纤维素，则形成的复合凝胶在改善其力学性能方面具有显著的效果。
细菌纤维素：细菌纤维素是一种环境友好型的高分子材料，具有高纯度、高结晶度、高聚合度、高拉伸强度和较强的生物相容性等特点。如果将细菌纤维素作为增强材料，在细菌纤维素网络中引入聚乙烯醇/聚丙烯酰胺水凝胶，将改善聚乙烯醇/聚丙烯酰胺水凝胶的力学性能，增大其优势。
 
背景：随着高分子水凝胶材料应用领域的扩展而对其性能提出了更高要求，研制和开发性能更为优良的高分子水凝胶材料已成为目前的研究热点。
目的：比较细菌纤维素改性前后的聚乙烯醇/聚丙烯酰胺水凝胶的力学性能，为其用于伤口敷料提供理论依据。
方法：实验利用细菌纤维素为增强材料，采用冷冻-熔融法，在细菌纤维素网络中引入聚乙烯醇/聚丙烯酰胺水凝胶，制备了细菌纤维素/聚乙烯醇/聚丙烯酰胺复合水凝胶，采用红外光谱、扫描电镜、热重分析、力学性能测试等手段对凝胶的结构和性能进行表征。
结果与结论：①通过扫描电镜和红外光谱图可以看到聚乙烯醇和聚丙烯酰胺结合到了细菌纤维素上，说明制备出了细菌纤维素/聚乙烯醇/聚丙烯酰胺复合水凝胶；②细菌纤维素增强复合凝胶的热稳定性、拉伸强度明显提高，而断裂伸长率较细菌纤维素增强前下降；③聚丙烯酰胺浓度为1.0%时，复合水凝胶的拉伸强度和断裂伸长率最大分别为331.79 kPa和105.33%，聚乙烯醇浓度为3.5%时，复合水凝胶的断裂伸长率最大为46.25%，而拉伸强度随聚乙烯醇浓度的增加而增加；④结果表明，细菌纤维素的引入明显提高了水凝胶材料的力学性能，增强了其稳定性，该复合水凝胶有望用作伤口敷料。

关键词: 生物材料, 材料相容性, 细菌纤维素, 聚乙烯醇, 聚丙烯酰胺, 复合水凝胶

Abstract:

BACKGROUND: With the extension of the application of polymer hydrogel materials, to develop polymer hydrogel materials with better performance has become a hotspot.
OBJECTIVE: To compare the mechanical properties of polyvinyl alcohol/polyacrylamide (PVA/PAM) composite hydrogel before and after modification by bacterial cellulose (BC), thereby providing a theoretic basis for its application in wound dressing.  
METHODS: BC-reinforced PVA/PAM hydrogels with different PVA/PAM contents were prepared using repeated freezing-thaw method. The BC/PVA/PAM hydrogels were characterized by infrared spectrum (IR) analysis, mechanical property test and scanning electron microscopy (SEM) observation, and thermogravimetric analysis.
RESULTS AND CONCLUSION: SEM and IR results showed the PVA and PAM were combined and attached onto the surface of BC, indicating a success in the preparation of BC/PVA/PAM hydrogels. Results from the thermogravimetric analysis showed that the thermal-stability of the BC/PVA/PAM hydrogels improved significantly. The mechanical test results demonstrated that the tensile strength of the PVA/PAM hydrogels was strongly enhanced, and the elongation at break was significantly lowered after being reinforced with BC. Furthermore, the content of PVA and PAM had an obvious effect on the mechanical properties of the composites. When the PAM content was 1.0%, the tensile strength and elongation at break of BC/PVA/PAM composites were at the highest level, which were 331.79 kPa and 105.33%, respectively; when the PVA content was 3.5%, the elongation at break of the BC/PVA/PAM composites was increased to the maximum (46.25%). Moreover, the results of this work reveal that the BC/PVA/PAM hydrogels exhibit some promising characteristics as artificial biomaterials. In general, the introduction of bacterial cellulose significantly improves the mechanical properties of the PVA/PAM hydrogels, and enhances the stability of the BC/PVA/PAM.

Key words: Cellulose, Hydrogel, Acrylamides, Tissue Engineering

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