中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (16): 2600-2605.doi: 10.3969/j.issn.2095-4344.2017.16.024

• 组织构建综述 tissue construction review • 上一篇    下一篇

组织工程化皮肤:从形态和功能安全替代的前景

王晓静1,王国伟2,惠光艳1,赵铱民3   

  1. 1解放军海军青岛第一疗养院口腔科,山东省青岛市  266071;2解放军海军第401医院崂山分院口腔科,山东省青岛市  266061;3解放军第四军医大学口腔医院,陕西省西安市  710032
  • 修回日期:2017-05-08 出版日期:2017-06-08 发布日期:2017-07-06
  • 通讯作者: 王晓静,解放军海军青岛第一疗养院口腔科,山东省青岛市 266071
  • 作者简介:王晓静,女,河南省洛阳市人,黎族,2012年第四军医大学毕业,博士,主治医师,目前主要从事组织工程再生医学领域及种植体技术的研究。
  • 基金资助:

    国家自然科学基金(81271104)

Tissue-engineered skin substitutes: a prospect evaluation from the aspects of morphology and function

Wang Xiao-jing1, Wang Guo-wei2, Hui Guang-yan1, Zhao Yi-min3   

  1. 1Department of Stomatology, Qingdao First Sanatorium of PLA Navy, Qingdao 266071, Shandong Province, China; 2Department of Stomatology, Laoshan Branch of No. 401 Hospital of PLA Navy, Qingdao 266061, Shandong Province, China; 3Stomatological Hospital of the Fourth Military Medical University, Xi’an 710032 , Shaanxi Province, China
  • Revised:2017-05-08 Online:2017-06-08 Published:2017-07-06
  • Contact: Wang Xiao-jing, Department of Stomatology, Qingdao First Sanatorium of PLA Navy, Qingdao 266071, Shandong Province, China
  • About author:Wang Xiao-jing, M.D., Attending physician, Department of Stomatology, Qingdao First Sanatorium of PLA Navy, Qingdao 266071, Shandong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81271104

摘要:

文章快速阅读:

文题释义:
真皮组织作用:
决定了机体皮肤的外观特征,并为皮肤提供了牢固的机械保护作用,真皮在愈合、生长、抗菌和防御外伤等方面起着重要作用。
Integra人造皮肤:是目前最为广泛应用的一种人工真皮替代物,可用于急性重度半厚和全厚皮肤烧伤以及烧伤后皮肤重建。

 

摘要
背景
:组织工程学是近年来迅速发展起来的一门新学科,涉及皮肤,角膜、骨、软骨、肌腱等多个领域,组织工程化皮肤为近年年的研究热点,组织工程化皮肤为临床解决皮肤缺损的修复提供了良好的前景。
目的:综述近年来组织工程化皮肤研究新进展。
方法:由第一作者用计算机检索Medline数据库(1996年至2017年),检索词为“Epidermis;dermis;tissue engineered skin”,语言设定英文,从表皮和真皮皮肤替代物对该领域的最新研究现状进行综述,探讨皮肤组织工程目前存在的问题及未来发展方向。
结果与结论:纳入文献65篇。复合皮肤替代物虽然包括了表皮与真皮两层结构,但缺乏毛囊、汗腺和皮脂腺等皮肤附属器。如何解决组织工程化皮肤缺少附属器的问题,仍是目前皮肤组织工程研究的热点和重要方向。组织工程化皮肤的构建要在短时间内,生产出能够永久覆盖的皮肤替代物,并可将黑色素细胞和朗格罕氏细胞构建入组织工程皮肤替代物结构中去。现存的生物组织工程皮肤替代物既无法从形态上也无法从功能上完全替代皮肤组织,还需未来进行深入研究。

 

 

ORCID: 0000-0001-8771-1099(王晓静)

关键词: 组织构建, 组织工程, 皮肤黏膜组织构建, 皮肤, 表皮替代物, 真皮替代物, 组织工程, 黑色素细胞, 朗格罕氏细胞, 国家自然科学基金

Abstract:

BACKGROUND: Tissue engineering is a booming subject in recent years, involving skin, cornea, bone, cartilage, tendon and etc. Noticeably, tissue-engineered skin is an issue of concern, which provides an alluring prospect for the repair of skin defects.
OBJECTIVE: To overview the latest research progress of tissue-engineered skin.
METHODS: A computer-based research of Medline database from 1996 to 2017 was performed, with the English keywords of “epidermis, dermis, tissue engineered skin”. The latest research status of tissue-engineered skin was summarized in views of epidermal and dermal substitutes, followed by exploring the problems and prospects of tissue-engineered skin.
RESULTS AND CONCLUSION: A total of 65 literatures were included. Complex skin substitutes include epidermis and dermis, in which hair follicles, sweat glands, sebaceous glands and other cutaneous appendages are absent. Therefore, how to solve above problems is a hotspot issue and major trend in tissue-engineered skin. Tissue-engineered skin aims to construct permanent skin substitutes containing melanocytes and Langerhans cells rapidly. Since the current tissue-engineered skin substitutes can completely replace skin tissues neither in morphology nor in function, in-depth studies are expected in the near future.

 

 

Key words: Tissue Engineering, Biocompatible Materials, Skin

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