中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (31): 5875-5880.doi: 10.3969/j.issn.2095-4344.2012.31.035

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

卵巢组织冷冻保存及移植技术进展

孙 愚1，李 青2，朱 江3   

  1. 四川大学华西医院，1肿瘤中心， 2医学中心临床医学院， 3胸部肿瘤科，四川省成都市 610041
  • 收稿日期:2012-01-29 修回日期:2012-04-13 出版日期:2012-07-29 发布日期:2012-07-29
  • 通讯作者: 朱江，硕士，四川大学华西医院胸部肿瘤科，四川省成都市 610041 zhujiang1@ medmail.com.cn
  • 作者简介:孙愚，女，1980年生，汉族，2005年西安交通大学毕业，医师，主要从事肿瘤化疗研究。 syjjbaby@sohu. com

Ovarian tissue cryopreservation and transplantation technology

Sun Yu1, Li Qing2, Zhu Jiang3   

  1. 1Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
    2Medical Center, West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
    3Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2012-01-29 Revised:2012-04-13 Online:2012-07-29 Published:2012-07-29
  • Contact: Zhu Jiang, Master, Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China zhujiang1@medmail.com.cn
  • About author:Sun Yu, Physician, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China syjjbaby@sohu.com

PDF

594

被引次数

4

摘要：

背景：生育力保存技术可以为因肿瘤或肿瘤治疗相关原因失去卵巢功能的女性患者提供恢复内分泌功能和生殖功能的机会。
目的：阐述了卵巢组织玻璃化冷冻以及冻融卵巢组织自体移植等技术在重建卵巢功能方面取得的进展和存在的问题。
方法：应用计算机检索CNKI和Pubmed数据库中1999-01/2011-12关于卵巢早衰的文章，在标题和摘要中以“卵巢早衰，玻璃化冷冻，卵巢移植”或“premature ovarian failure，vitrification freeze，ovary transplantation”为检索词进行检索。最终选择关于卵巢玻璃化冷冻和自体移植的40篇文献进行综述。
结果与结论：对于重建肿瘤相关性卵巢早衰患者卵巢功能，卵巢组织玻璃化冷冻保存和自体原位移植具有广泛临床应用前景。不仅能够恢复自然生育力、生殖功能及内分泌功能，而且不存在免疫排斥，也没有伦理学争议，安全方便。可以相信，随着医学技术的发展和进步，卵巢组织冷冻移植技术将越发成熟，为更多的女性肿瘤患者保存生育力和内分泌功能带来福音。

关键词: 肿瘤, 卵巢早衰, 玻璃化冷冻, 自体移植, 功能重建

Abstract:

BACKGROUND: Fertility preservation techniques can provide the opportunity to restore the endocrine function and reproductive function for the female patients that loss of ovarian function due to tumor or cancer treatment-related causes.
OBJECTIVE: To review the progress and problem on the application of vitrification freeze of ovarian tissues and freeze-thaw ovarian tissue autograft in reconstruction of ovary function.
METHODS: A computer-based search was performed on the CNKI database and PubMed database from January 1999 to December 2011 for the articles about premature ovarian failure. The key words were “premature ovarian failure, vitrification freeze, ovary transplantation” in English and Chinese. Finally, 40 articles relate to the vitrification freeze of ovarian tissues and freeze-thaw ovarian tissue autograft were included to review.
RESULTS AND CONCLUSION: As for the methods to reconstruct the ovary function of tumor related premature ovarian failure patient, both methods that vitrification freeze of ovarian tissues and freeze-thaw ovarian tissue autograft have bright future in clinical application, which can not only restore natural fertility, genital function and endocrine function, but also are safe and convenient without immunological rejection or ethnics disputes. It is believed that the technique of ovarian tissue cryopreserved transplantation will be more advanced along with the development of the medical research in the future, and it will raise hopes by reconstructing their fertility and endocrine function for those female patients suffering from tumor.

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