中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (14): 2652-2655.doi: 10.3969/j.issn.1673-8225.2012.14.038

• 干细胞临床实践 clinical practice of stem cells • 上一篇    下一篇

脐带间充质干细胞治疗脊髓小脑性共济失调12例**★

邱  云1， 汪  铮1，路红社2，许  鹏2，陈文怡2，路延光2，丁永红2   

  1. 上海交通大学医学院，上海消化疾病研究所干细胞实验室，上海市  200001；2解放军455医院干细胞移植中心，上海市  200052
  • 收稿日期:2011-09-07 修回日期:2011-09-15 出版日期:2012-04-01 发布日期:2012-04-01
  • 通讯作者: 汪铮，博士，副教授，上海交通大学医学院，上海消化疾病研究所干细胞实验室，上海市 200001
  • 作者简介:邱云★，女，1984年生，湖南省邵阳市人，汉族，上海交通大学医学院在读硕士，主要从事干细胞相关研究。
  • 基金资助:

    上海市科委浦江人才计划项目(09PJ1407300)；国家自然科学基金项目(30971468)。

Transplantation of umbilical cord mesenchymal stem cells for treatment of autosomal dominant spinocerebellar ataxias in 12 cases**

Qiu Yun1, Wang Zheng1, Lu Hong-she2, Xu Peng2, Chen Wen-yi2, Lu Yan-guang2, Ding Yong-hong2   

  1. 1Laboratory of Stem Cells, Shanghai Institute of Digestive Disease at Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai  200001, China; 2Center of Stem Cells Transplantation, the 455 Hospital of Chinese PLA, Shanghai  200052, China
  • Received:2011-09-07 Revised:2011-09-15 Online:2012-04-01 Published:2012-04-01
  • Contact: Wang Zheng, Doctor, Associate professor, Laboratory of Stem Cells, Shanghai Institute of Digestive Disease at Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China zheng.w.dr@gmail.com
  • About author:Qiu Yun★, Studying for master’s degree, Laboratory of Stem Cells, Shanghai Institute of Digestive Disease at Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China qyun200911@yahoo.cn
  • Supported by:

    Pujiang Talents Plan of Shanghai Municipal Science and Technology Committee, No. 09PJ1407300*; the National Natural Science Foundation of China, No.30971468*

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摘要：

背景：目前尚未见应用脐带间充质干细胞治疗脊髓小脑性共济失调的报道。
目的：观察脐带间充质干细胞治疗脊髓小脑性共济失调的临床效果。
方法：选择2010-09/12解放军455医院干细胞移植中心收治的12例脊髓小脑共济失调患者，给予脐带间充质干细胞鞘内注射，每次107个细胞，1次/周，4次为1个疗程。
结果与结论：患者治疗后1个月与治疗前比较国际合作共济失调评分量表评分及日常生活量表评分均明显降低(P < 0.05)，提示患者的神经功能显著改善，总有效率为16.7%。说明脐带间充质干细胞鞘内注射治疗可以在一定程度上改善脊髓小脑性共济失调患者的临床症状，提高患者生活质量。

关键词: 脊髓小脑性共济失调, 脐带基质, 间充质干细胞, 移植

Abstract:

BACKGROUND: There is no study addressing transplantation of umbilical cord mesenchymal stem cells for the treatment of spinocerebellar ataxia.
OBJECTIVE: To study the clinical effect of human umbilical cord stem cells transplantation in the treatment of autosomal dominant spinocerebellar ataxias.
METHODS: Spinocerebellar ataxias patients selected from Stem Transplantation Center of the 455 Hospital of Chinese PLA were treated with umbilical cord mesenchymal stem cells transplantation via intrathecal injection. The number of umbilical cord mesenchymal stem cells was 107 per transplantation, once per week, for 4 weeks.
RESULTS AND CONCLUSION: Both the total score of the International Cooperative Ataxia Rating Scale and Activities of Daily Living score were significantly decreased at 1 month after transplantation compared with before treatment (P < 0.05). The nerve function was significantly improved and the total effective rate was up to 16.7%. Experimental findings indicate that, transplantation of umbilical cord mesenchymal stem cells via intrathecal injection is a feasible and effective treatment to ameliorate the clinical efficacy of spinocerebellar ataxias patients and improve their quality of life.

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