中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (48): 9040-9043.doi: 10.3969/j.issn.1673-8225.2011.48.027

• 骨与关节损伤基础实验 basic experiments of bone and joint injury • 上一篇    下一篇

模拟腰椎间盘髓核摘除后疲劳载荷对腰椎稳定性的影响

宋  升1,芮永军1,孙振中1,华国军2,樊  嵘2   

  1. 1无锡市第九人民医院,无锡市手外科(骨科)医院骨科,江苏省无锡市  214062
    2解放军第101医院南京军区军事训练医学研究所,江苏省南京市  214044
  • 收稿日期:2011-07-01 修回日期:2011-09-10 出版日期:2011-11-26 发布日期:2011-11-26
  • 作者简介:宋升★,男,1975年生,江苏省徐州市人,汉族,2009年江苏大学毕业,硕士,主治医师,主要从事骨科创伤研究。 songshengss007@163.com

Effects of fatigue load on lumbar stability after simulated lumbar diskectomy

Song Sheng1, Rui Yong-jun1, Sun Zhen-zhong1, Hua Guo-jun2, Fan Rong2   

  1. 1Department of Orthopaedics, Ninth People’s Hospital of Wuxi, Wuxi  214062, Jiangsu Province, China
    2Military Medical Research Institute of Nanjing Military Region, the 101 Hospital of Chinese PLA, Nanjing  214004, Jiangsu Province, China
  • Received:2011-07-01 Revised:2011-09-10 Online:2011-11-26 Published:2011-11-26
  • About author:Song Sheng★, Master, Attending physician, Department of Orthopaedics, Ninth People’s Hospital of Wuxi, Wuxi 214062, Jiangsu Province, China songshengss007@163.com

摘要:

背景:腰椎间盘髓核摘除术后何时下床活动目前尚无统一标准,实验拟通过腰椎间盘髓核摘除术后早期的生物力学变化来指导患者进行功能锻炼。
目的:观察腰椎间盘髓核摘除后疲劳载荷对腰椎稳定性的影响。
方法:取3具新鲜猪脊柱标本,制成12个脊柱功能单位,随机分为A,B,C组,行单侧椎板开窗髓核摘除后,在不同循环载荷压力(500~1 000 N,500~2 000 N,500~3 000 N)下行疲劳载荷实验。
结果与结论:A,B组椎间盘高度、刚度差异无显著性意义(P > 0.05),应变增大差异有显著性意义(P < 0.05);B,C组椎间盘高度和刚度的降低、应变的增大差异均有显著性意义(P < 0.01)。循环载荷后3组间比较,椎间盘高度、应变、刚度的变化幅度均随载荷压力的增大而变大(P < 0.05)。结果说明髓核摘除后较大的载荷会破坏腰椎的稳定性。

关键词: 髓核摘除术, 猪, 疲劳载荷, 腰椎, 稳定性

Abstract:

BACKGROUND: At present, there is not a unified standard about when to start ambulation after lumbar diskectomy. In the present experiment, we guided functional exercises of patients after lumbar diskectomy based on early biomechanical changes.
OBJECTIVE: To explore the effects of fatigue load on lumbar stability after lumbar diskectomy.
METHODS: Twelve functional spinal units were taken from 3 fresh porcine spines and divided into A group, B group and C group randomly. Fatigue load test was performed in all cases with different cycle load pressures (500-1 000 N, 500-2 000 N, 500-
3 000 N) after unilateral lumbar diskectomy.
RESULTS AND CONCLUSION: There was no significant difference between A group and B group in disc height and stiffness (P > 0.05), but the increased strain showed significant difference (P < 0.05); Disc height and stiffness in B group and C group was reduced, strain was increased, and all these differences were significant (P < 0.01). Change ranges of disc height, strain and stiffness in the three groups were increased with the increase of the load pressure after cyclic tensile test (P < 0.05). The results showed that a bigger fatigue load can damage lumbar stability after lumbar diskectomy. 

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