中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (14): 2615-2618.doi: 10.3969/j.issn.1673-8225.2011.14.032

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞的诱导分化及其恶性转化

袁小刚，吕农华   

  1. 南昌大学第一附属医院消化科，江西省南昌市330006
  • 收稿日期:2010-12-03 修回日期:2011-01-20 出版日期:2011-04-02 发布日期:2013-11-02
  • 通讯作者: 吕农华，硕/博士生导师，主任医师，教授，南昌大学第一附属医院消化科，江西省南昌市 330006 lunonghua@163.com
  • 作者简介:袁小刚★，男，1983年生，江西省樟树市人，汉族，南昌大学医学院在读硕士，主要从事幽门螺杆菌感染的基础与临床研究。 xiaogangyuan@hotmail.com
  • 基金资助:

    江西省研究生创新专项资金(YC09A017)。

Induced differentiation and malignant transformation of bone marrow mesenchymal stem cells

Yuan Xiao-gang, Lü Nong-hua   

  1. Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Received:2010-12-03 Revised:2011-01-20 Online:2011-04-02 Published:2013-11-02
  • Contact: Lü Nong-hua, Master’s/Doctoral supervisor, Chief physician, Professor, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China lunonghua@163.com
  • About author:Yuan Xiao-gang★, Studying for master’s degree, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China xiaogangyuan@hotmail.com
  • Supported by:

    Jiangxi Innovative Special Foundation for Graduate Students, No. YC09A017*

PDF

503

被引次数

18

摘要：

背景：近年来有研究认为骨髓间充质干细胞可发生恶性转化，成为恶性肿瘤的细胞起源。
目的：综述近年来诱导骨髓间充质干细胞分化的方法、定向分化的细胞种类及其恶性转化的相关研究进展。
方法：应用计算机分别以“bone marrow mesenchymal stem cells” AND “differentiation”和“bone marrow mesenchymal stem cells” AND “transformation” 为关键词检索Pubmed数据库(http://www.ncbi.nlm.nih.gov/pubmed)、SPRINGER数据库(http://www.springerlink.com)及Elsevier数据库(http://www.sciencedirect.com)，时间限定为2000-01/2010-11，语言种类为English。通过阅读标题和摘要进行初筛，排除重复性研究、Meta分析，选择近期发表或发表在权威杂志的31篇相关文献进行综述。
结果与结论：体外诱导骨髓间充质干细胞分化的方法主要有特定条件培养液、细胞共培养和损伤病理模型组织细胞或血清3大类。骨髓间充质干细胞可定向诱导分化为内、中及外胚层来源的几乎所有组织类型的细胞。有实验研究及临床病例个案报道，骨髓间充质干细胞可发生恶性转化，成为多种肿瘤的细胞起源。这提示骨髓间充质干细胞临床应用的安全性问题值得进一步深入研究，同时这也可能为肿瘤生物学研究提供了新视野。

关键词: 骨髓间充质干细胞, 分化, 恶性转化, 诱导方法, 研究进展

Abstract:

BACKGROUND: Previous studies have demonstrated that bone marrow mesenchymal stem cells (BMSCs) can undergo malignant transformation and become the origin of malignant tumor cells.
OBJETIVE: To review the research progress in the methods and directions of induced differentiation and malignant transformation of BMSCs in recent years.
METHODS: The Pubmed database (http://www.ncbi.nlm.nih.gov/pubmed), SPRINGER database (http://www.springerlink.com) and Elsevier database (http://www.sciencedirect.com) were searched online with the key words of "mesenchymal stem cells" AND "differentiation" or "bone marrow mesenchymal stem cells" AND "transformation" in English. Papers were included from January 2000 to November 2010, Language was limited to English. Following reading titles and abstracts, repetitive researches and Meta analysis were excluded, 31 related articles recently published or in authoritative journals were reviewed.
RESULTS AND CONCLUSION: There are 3 approaches can be used for inducing BMSCs to differentiate in vitro at least, such as certain conditioned induction mediums, co-culture with purpose cells and cells or serum derived from pathological damaged model. BMSCs can be directionally differentiationed into almost all human tissue types’ cells that from the endoderm, mesoderm and ectoderm. Experimental researchs and clinical case reports suggest that BMSCs can undergo malignant transformation and become the cell origin of many tumors. It is indicated that the security problems of BMSCs in clinical application need further study, and it may also provide a new vision for future tumor biological research.

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