中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (13): 2403-2407.doi: 10.3969/j.issn.1673-8225.2011.13.029

• 数字化骨科 digital orthopedics • 上一篇    下一篇

Gabor小波变换和希尔伯特变换研究海马区癫痫发作间期尖波对theta振荡能量特性的影响

董国亚1，陈小刚1，周欣花2，李文文1，葛曼玲1   

  1. 1河北工业大学电气工程学院生物医学工程系，天津市  300130
    2河北交通职业技术学院轮机工程系，天津市  300381
  • 收稿日期:2010-11-03 修回日期:2010-12-15 出版日期:2011-03-26 发布日期:2013-10-23
  • 作者简介:董国亚☆，女，1971年生，天津市人，汉族，2003年清华大学生物医学工程专业毕业，博士，副教授，主要从事医学信号处理、医学图像处理、电阻抗成像等研究。 dongguoya@ gmail.com
  • 基金资助:

    河北省自然科学基金项目(E2009000062, E2010000053)。

Effect of the interictal spike and waves of epileptic seizure on theta oscillation in hippocampal CA1: A Gabor wavelet and Hilbert transform study

Dong Guo-ya1, Chen Xiao-gang1, Zhou Xin-hua2, Li Wen-wen1, Ge Man-ling1   

  1. 1Department of Biomedical Engineering, School of Electrical Engineering, Hebei University of Technology, Tianjin  300130, China
    2Department of Marine Engineering, Hebei Jiaotong Vocational and Technical College, Tianjin  300381, China
  • Received:2010-11-03 Revised:2010-12-15 Online:2011-03-26 Published:2013-10-23
  • About author:Dong Guo-ya☆, Doctor, Associate professor, Department of Biomedical Engineering, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China dongguoya@gmail. com
  • Supported by:

    the Natural Science Foundation of Hebei Province, No. E2009000062*, E2010000053*

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摘要：

背景：Theta振荡是海马区神经活动具有代表性的特征，也是从更为微观领域研究癫痫与认知关系的重要切入点。
目的：分析海马区癫痫发作间期尖波对Theta振荡能量特性的影响。
方法：采用法国马赛地中海大学医学院提供的8只致痫大鼠和10例患者脑电数据，同时采集相应致痫大鼠在注射致痫药物无发作间期尖波出现时的脑电数据作对照。利用Gabor小波变换和希尔伯特变换分别提取Theta振荡在尖波作用前、后的能量，并将这两种方法提取Theta振荡能量的结果进行比较。
结果与结论：癫痫组Theta能量动态特性：癫痫发作间期尖波削弱了Theta振荡能量，而在经历癫痫发作间期后的较长时间，Theta振荡能量得到恢复。推测脑默认网络的连接强度受到癫痫状态的影响，存在变弱的可能。而默认网络的减弱，是认知功能下降的一种病理基础。

关键词: 发作间期尖波, Theta振荡, 认知, 能量, 海马, 癫痫, Gabor小波变换, 希尔伯特变换

Abstract:

BACKGROUND: Theta oscillation is a representative characteristic of neural activity in hippocampus and serves as the starting point for the study of epilepsy and cognition in micro-ways.
OBJECTIVE: To investigate the effects of the interictal spike and waves of epileptic seizure on theta oscillation in hippocampal CA1.
METHODS: The iEEG data of 8 epileptic rats and 10 patients from School of Medicine, Mediterranean University, Marseilles, France were collected, and their corresponding iEEG data without spike and waves as controls. Gabor wavelet and Hilbert transform were used for extraction of the power of theta oscillation before and after the spike waves. The outcomes of Gabor wavelet and Hilbert transform were compared.
RESULTS AND CONCLUSION: Dynamic characteristics of theta power in epilepsy group: Epileptic interictal spike and waves weaken the theta oscillation power, but after a long period of spike and waves, theta oscillation power recovered. It is speculated that the brain's default network connection strength is affected by status epilepticus and may be weakened. However, the weakening of the default network is a pathological basis of cognitive decline.

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