中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (18): 3289-3292.doi: 10.3969/j.issn.1673-8225.2010.18.014

• 细胞与组织移植 cell and tissue transplantation • 上一篇    下一篇

体外受精-胚胎移植者体质量指数对妊娠结局的影响

李  星，杨  菁，尹太郎，徐望明，李金萍，赵庆红   

  1. 武汉大学人民医院生殖医学中心，湖北省武汉市 430060
  • 出版日期:2010-04-30 发布日期:2010-04-30
  • 通讯作者: 杨 菁，教授，博士生导师，武汉大学人民医院生殖医学中心，湖北省武汉市 430060 dryangqing@hotmail.com
  • 作者简介:李 星★，女，1985年生，山东省莒县人，汉族，武汉大学在读硕士，主要从事生殖内分泌研究。 xj_foreverfriends@126.com

Effects of body mass index on the outcome of in vitro fertilization and embryo transfer treatment

Li Xing, Yang Jing, Yin Tai-lang, Xu Wang-ming, Li Jin-ping, Zhao Qing-hong   

  1. Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan  430060, Hubei Province, China
  • Online:2010-04-30 Published:2010-04-30
  • Contact: Yang Jing, Professor, Doctoral supervisor, Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China dryangqing@hotmail.com
  • About author:Li Xing★, Studying for master’s degree, Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China xj_foreverfriends@126.com

PDF

782

被引次数

9

摘要：

背景：超重及肥胖对体外受精-胚胎移植的妊娠结局是否存在影响目前尚无统一定论。
目的：验证体外受精-胚胎移植者体质量指数对其妊娠结局是否有影响。
方法：选择体外受精-胚胎移植女性患者184例，按体质量指数分为3组：偏瘦组(体质量指数< 18.5 kg/m2)、正常体质量组(18.5 kg/m2 ≤ 体质量指数< 24 kg/m2)、超重及肥胖组(体质量指数≥ 24 kg/m2)。对患者实施超促排卵方案，体外受精、胚胎移植及妊娠的确定等均按本中心工作常规进行。比较3组患者促性腺激素用药天数和剂量、人绒毛膜促性腺激素注射日雌二醇水平、获卵数、受精率、优胚率、种植率、临床妊娠率、流产率的差别。
结果与结论：在促性腺激素用量上，超重及肥胖组用量明显高于其他两组(P < 0.05)，且随着体质量指数的升高，促性腺激素用量随之增加。3组在促性腺激素刺激天数、人绒毛膜促性腺激素注射日雌二醇水平、获卵数、受精率、优胚率、种植率、临床妊娠率及流产率间差异均无显著性意义(P > 0.05)。说明在进行体外受精-胚胎移植促排卵过程中，超重及肥胖患者与正常体质量及偏瘦患者相比，需要更大的促性腺激素用量；但在妊娠结局方面，超重及肥胖对体外受精-胚胎移植的结局无显著影响。

关键词: 体质量指数, 体外受精-胚胎移植, 妊娠, 移植, 体质量

Abstract:

BACKGROUND: Whether overweight and obesity have impact on the outcome of in vitro fertilization and embryo transfer (IVF-ET) treatment remains poorly understood.
OBJECTIVE: To investigate the effect of women’s body mass index (BMI) on the outcome of IVF-ET treatment.
METHODS: A total of 184 cases were divided into 3 groups according to BMI: lankness group (BMI < 18.5 kg/m2), normal group (18.5 kg/m2 ≤ BMI < 24 kg/m2), overweight and obesity group (BMI ≥ 24 kg/m2). Treatments of ovulation induction and IVF-ET were regularly performed in the Reproductive Medical Center, Renmin Hospital of Wuhan University. The duration and dose of gonadotrophic hormone (GTH) treatment, estradiol level at the day of human chorionic gonadotropin (hCG) injection, and the differences of retrieved oocytes numbers, fertility rate, embryo quality, implantation rate, pregnancy rate and abortion rate were compared.
RESULTS AND CONCLUSION: The dose of GTH used was in the overweight and obesity group was greater than that of the other groups (P < 0.05), and the dose was increased with BMI increasing. There was no significant difference in other aspects such as estradiol level, retrieved oocytes numbers, fertility rate, embryo quality, implantation rate, pregnancy rate and abortion rate at the day of hCG injection among the three groups (P > 0.05). All results demonstrated that overweight and obese patients require a higher hCG dose to achieve follicular maturation than normal weight patients. However, overweight and obesity does not affect negatively results of IVF-ET.

中图分类号: