中国组织工程研究 ›› 2020, Vol. 24 ›› Issue (14): 2271-2276.doi: 10.3969/j.issn.2095-4344.2443

• 组织构建综述 tissue construction review • 上一篇    下一篇

非编码RNA在周围神经损伤修复中的重要角色和作用

罗选翔1,2,冯  虎2,经  历1,2,潘  彬1   

  1. 1徐州医科大学附属医院骨科,江苏省徐州市  221000;2徐州医科大学,江苏省徐州市  221000
  • 收稿日期:2019-07-12 修回日期:2019-07-24 接受日期:2019-08-23 出版日期:2020-05-18 发布日期:2020-03-18
  • 通讯作者: 冯虎,硕士,教授,主任医师,徐州医科大学附属医院脊柱外科,江苏省徐州市 221000
  • 作者简介:罗选翔,男,1995年生,江苏省南京市人,汉族,徐州医科大学在读硕士,主要从事脊柱等相关骨科疾病的研究。
  • 基金资助:
    国家自然科学基金(81801213)

Important roles of non-coding RNA in peripheral nerve repair 

Luo Xuanxiang1, 2, Feng Hu2, Jing Li1, 2, Pan Bin1   

  1. 1Department of Orthopedics, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; 2Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
  • Received:2019-07-12 Revised:2019-07-24 Accepted:2019-08-23 Online:2020-05-18 Published:2020-03-18
  • Contact: Feng Hu, Master, Professor, Chief physician, Department of Spinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
  • About author:Luo Xuanxiang, Master candidate, Department of Orthopedics, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81801213

摘要:

文题释义:
非编码RNA:是指从基因组上转录形成但不翻译成蛋白质的RNA,主要包括miRNA、circRNA、lncRNA;非编码RNA可以作为转录调控因子和转录后调控因子,在转录过程中发挥重要的作用。
周围神经损伤:周围神经损伤会导致神经支配区域运动及感觉功能的下降甚至缺失,在临床上有着较高的发生率和致残率,严重影响患者生活质量,并且造成巨大的社会经济负担。

背景:非编码RNA在体内广泛分布于神经系统中,在神经损伤模型中可以观察到非编码RNA表达的显著变化。这表明非编码RNA可能成为解决周围神经修复挑战的潜在靶点。

目的:综述微小RNA、环状RNA、长链非编码RNA在周围神经损伤后修复的作用机制,并试图确定周围神经损伤的可能治疗方向。

方法:第一作者应用计算机检索2001年1月至2019年4月中国期刊全文数据库CNKI和PubMed数据库相关文章。中文检索词“非编码RNA,miRNA,circRNA,lncRNA,周围神经损伤”;英文检索词“non-coding RNA,miRNA,circRNA,lncRNA,peripheral nerve injury”,根据纳入标准及排除标准摘选43篇文章进行分析讨论。

结果与结论:①miRNA可以作用于特定的信号通路,同时调控许旺细胞的凋亡、生长、增殖和分化,参与周围神经损伤后修复;②环状RNA与miRNA发生海绵样作用,竞争性抑制miRNA的转录调控,发挥相应的生物学功能;③大量的长链非编码RNA在周围神经损伤后发生差异性表达,在周围神经再生中发挥着重要作用。

ORCID: 0000-0002-8792-8738(罗选翔)

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

关键词: 周围神经损伤, 修复, 非编码RNA, miRNA, circRNA, lncRNA, 许旺细胞, 临床前景

Abstract:

BACKGROUND: Non-coding RNA is widely distributed in the nervous system in vivo and a significant change in the expression of non-coding RNA has been observed in a neural injury model. This suggests that non-coding RNA may serve as a potential target for resolving the challenges of peripheral nerve repair.

OBJECTIVE: To summarize the mechanisms of microRNA, circular RNA and long non-coding RNA in the process of repair after peripheral nerve injury with the attempt to determine the possible treatment of peripheral nerve injury.

METHODS: The first author retrieved the relevant literatures in CNKI and PubMed databases published from January 2001 to April 2019. The key words were “non-coding RNA, miRNA, circRNA, lncRNA, peripheral nerve injury” in Chinese and English, respectively. Forty-three literatures were included in accordance with the exclusion and inclusion criteria.

RESULTS AND CONCLUSION: (1) MicroRNAs can act on certain signal pathways, regulate the apoptosis, growth, proliferation and differentiation of Schwann cells and participate in the repair of peripheral nerve injury. (2) Circular RNAs act as microRNA sponges to competitively inhibit the transcription in microRNA, and exert corresponding biological functions. (3) A large amount of long non-coding RNAs are expressed after peripheral nerve injury, and play a key role in the peripheral nerve regeneration.

Key words: peripheral nerve injury, repair, non-coding RNA, miRNA, circRNA, lncRNA, Schwann cells, clinical prospects

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