中国组织工程研究

中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (20): 3147-3151.doi: 10.3969/j.issn.2095-4344.2017.20.006

• 软骨组织构建 cartilage tissue construction • 上一篇    下一篇

不同压缩条件下关节软骨的回弹力学性能

许西凡，高丽兰，门玉涛，董培蓓，张春秋   

  1. 天津市先进机电系统设计与智能控制重点实验室，天津理工大学机械工程学院，天津市  300084
  • 修回日期:2017-02-13 出版日期:2017-07-18 发布日期:2017-07-28
  • 通讯作者: 张春秋，博士，教授，天津市先进机电系统设计与智能控制重点实验室，天津理工大学机械工程学院，天津市 300384
  • 作者简介:许西凡，男，1989年生，山东省人，汉族，天津理工大学在读硕士，主要从事实验室仪器设计分析及生物力学方面的研究。
  • 基金资助:

    国家自然科学基金资助(11572222；11432016；11402171)

Micromechanical properties of articular cartilage resilience under different compression conditions

Xu Xi-fan, Gao Li-lan, Men Yu-tao, Dong Pei-bei, Zhang Chun-qiu   

  1. Tianjin Key Laboratory of Advanced Electromechanical System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300084, China
  • Revised:2017-02-13 Online:2017-07-18 Published:2017-07-28
  • Contact: Zhang Chun-qiu, M.D., Professor, Tianjin Key Laboratory of Advanced Electromechanical System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300084, China
  • About author:Xu Xi-fan, Studying for master’s degree, Tianjin Key Laboratory of Advanced Electromechanical System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300084, China
  • Supported by:

    the National Natural Science Foundation of China, No. 11572222, 11432016, and 11402171

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摘要：

文章快速阅读：

 

文题释义：
关节软骨：属于透明软骨，表面光滑，呈淡蓝色，有光泽，没有神经支配，也没有血管，其营养成分必须从关节液中取得，而其代谢废物也必须排至关节液中，关节软骨的这种营养代谢必须通过关节运动，使关节软骨不断的受到压力刺激才行，所以关节运动对于维持关节软骨的正常结构起重要的作用。
黏弹性：对应力的响应兼有弹性固体和黏性流体的双重特性称黏弹性，也称之为固、液二项性。

 

摘要
背景：研究关节软骨的回弹性能对人的作息以及和人工软骨回弹性能的匹配度等都具有很大的参考意义。
目的：分析不同载荷和不同时间下关节软骨回弹的微观力学性能。
方法：运用MTF-100拉力机对涂有示踪剂的猪软骨试件进行压缩，用其附带的CCD对软骨压缩和回弹状态进行拍照记录，采用数字图像相关技术进行图像处理。
结果与结论：①回弹时软骨浅表层回弹的应变减少幅度最大，中间层次之，深层最小，分别从20%、10%、6%左右降到3%所用的时间相似；②回弹时间越长，软骨不同层区的应变变化越缓慢，但最终应变会小于1%；③相同层区不同压缩载荷作用下，在回弹初期，载荷越大，软骨回弹应变变化越快；在回弹后期，载荷越小，回弹应变变化越快；④相同层区不同持续压缩时间和载荷的影响相似；⑤从实验数据看，关节软骨90%左右的回弹主要集中在前15 min左右。关节软骨不同层区的力学回弹性能与其加载载荷和加载持续时间都有密切的相关性，载荷和压缩时间的增加都会对回弹产生不利的影响。从回弹后期数据说明经过一定的时间基本能回弹到压缩前的状态。

 

 

ORCID: 0000-0003-4235-5232(许西凡)

关键词: 组织构建, 软骨组织工程, 关节软骨, 压缩回弹, 不同层区, 力学性能, 国家自然科学基金

Abstract:

BACKGROUND: It is of great significance to study the resilience of articular cartilage for human daily routine  and their match quality.
OBJECTIVE: To analyze the micromechanical properties of articular cartilage resilience under different loads and at time points.
METHODS: The swine cartilage samples coated with tracers were compressed using the MTF-100 tensile machine, and the cartilage compression and resilience were recorded by CCD. Images were processed using digital image correlation technology.
RESULTS AND CONCLUSION: During resilience, the strain value on the superficial surface of the cartilage was decreased most, successively followed by the middle layer and the deep layer, while the time of a decrease from 20%, 10% and 6% to 3% was similar. The longer the resilience time was, the more slowly the strain changed in different layers of the cartilage, but the ultimate strain was less than 1%. On the same layer under different compressive stress, the larger load caused faster strain change firstly, and then the smaller load brought about faster strain change. The effect of different continuous compressive time on the same layer of cartilage was similar with the load. These results showed that 90% resilience of the articular cartilage occurred within the first 15 minutes. The mechanical resilience of different layers of the articular cartilage has a close relationship with the loading and the loading time, and both compressive time and loading do harm to the resilience of articular cartilage. Besides, the cartilage will rebound to the state before compression.

 

Key words: Cartilage, Articular, Biomechanics, Elasticity, Tissue Engineering

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