中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (28): 4561-4566.doi: 10.12307/2021.073

• 生物材料综述 biomaterial review • 上一篇    下一篇

鱼皮胶原在组织工程中的研究进展与主要应用

朱必康1，罗善超2，罗世兴2   

  1. 1广西生物医药协同创新中心，广西医科大学，广西壮族自治区南宁市   530021；2广西博士后创新实践基地，广西医科大学第九附属医院，广西壮族自治区北海市   536000
  • 收稿日期:2020-09-03 修回日期:2020-09-05 接受日期:2020-10-16 出版日期:2021-10-08 发布日期:2021-05-22
  • 通讯作者: 罗世兴，主任医师，博士，硕士生导师，广西医科大学第九附属医院，广西壮族自治区北海市 536000
  • 作者简介:朱必康，男，1993年生，湖北省咸宁市人，广西医科大学在读硕士，主要从事创伤骨科、生物材料与骨组织工程研究。
  • 基金资助:
    广西研究生教育创新计划项目(YCSW2020129)，项目负责人：朱必康

Progress and main application of fish skin collagen in tissue engineering

Zhu Bikang1, Luo Shanchao2, Luo Shixing2   

  1. 1Guangxi Collaborative Innovation Center for Biomedicine, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; 2Guangxi Postdoctoral Innovation Practice Base, The Ninth Affiliated Hospital of Guangxi Medical University, Beihai 536000, Guangxi Zhuang Autonomous Region, China
  • Received:2020-09-03 Revised:2020-09-05 Accepted:2020-10-16 Online:2021-10-08 Published:2021-05-22
  • Contact: Luo Shixing, Chief physician, MD, Master’s supervisor, Guangxi Postdoctoral Innovation Practice Base, The Ninth Affiliated Hospital of Guangxi Medical University, Beihai 536000, Guangxi Zhuang Autonomous Region, China
  • About author:Zhu Bikang, Master candidate, Guangxi Collaborative Innovation Center for Biomedicine, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    Innovation Project of Guangxi Graduate Education, No.YCSW2020129 (to ZBK)

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摘要：

文题释义：
组织工程：是一门以细胞生物学和材料科学相结合进行体外或体内构建组织或器官的新兴学科，这项技术的开发有助于恢复、维持或改善因创伤或疾病等而受损或失去的组织或器官的功能。目前已知的组织工程主要有两种策略，一是仅使用生物材料帮助组织或器官自我再生，二是使用负载相关细胞和生长因子的生物材料来促进组织再生。
鱼皮胶原：是指从海洋鱼类皮肤中提取的、无宗教限制和疾病传播风险，且具有良好的理化性能、低免疫原性、高生物相容性和生物活性的一种胶原。


背景：胶原是组织工程中应用广泛的支架材料之一，但商业化的胶原蛋白主要来源于猪皮、牛皮和其他哺乳动物，均存在一些人畜共患疾病传播的风险和宗教限制。现今，具有众多功能特性且无疾病和宗教限制的鱼皮胶原生物材料成为组织工程的研究热点。
目的：综述鱼皮胶原的提取、功能改性及其在组织工程中的研究进展及主要应用。
方法：由第一作者检索2005至2020年PubMed、中国知网、万方和其他数据库中收录的与组织工程和鱼皮胶原相关的文献，通过优先选择相关度高且权威杂志上的文章。英文检索词为“fish skin collagen；tissue engineering”，中文检索词为“鱼皮胶原；组织工程”。
结果与结论：鱼皮胶原具有良好的理化性能、机械强度和生物相容性，因有望替代哺乳动物胶原蛋白而受到广大生物医学研究者的关注，被广泛用于各种组织工程中，如：皮肤伤口愈合、骨和软骨组织工程、血管和神经再生等。但针对基础研究转化为临床应用上存在颇多问题，如：对于鱼皮胶原工厂化生产时选用何种提取方式更为快捷高效；鱼皮胶原通过何种功能改性方案来达到复合构建移植体的标准，即如何提高鱼皮胶原基材料的力学性能、降解性能等来支撑骨与软骨组织再生修复；如何构建支架材料来提高皮肤创伤的完美快速修复等。
https://orcid.org/0000-0003-0922-8637 (朱必康)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

关键词: 鱼皮胶原, 组织工程, 提取, 改性, 骨组织工程, 软骨组织工程, 皮肤组织工程, 生物医学应用

Abstract: BACKGROUND: Collagen is one of the widely used scaffold materials in tissue engineering, but commercial collagen is mainly derived from pigskin, cowhide, and other mammals, and there are some zoonotic diseases risks, and religious restrictions. Nowadays, fish skin collagen biomaterials with many functional properties without disease or religious restrictions have become a research hotspot in tissue engineering.
OBJECTIVE: To review the extraction, functional modification of fish skin collagen, and its research progress, and main applications in tissue engineering.
METHODS: The first author retrieved the literature related to tissue engineering and fish skin collagen included in PubMed, CNKI, Wanfang, and other databases from 2005 to 2020 and selected articles in highly relevant and authoritative journals. The English and Chinese search terms were “fish skin collagen; tissue engineering”.
RESULTS AND CONCLUSION: Fish skin collagen has good physical and chemical properties, mechanical strength, and biocompatibility. It is expected to replace mammalian collagen and has attracted the attention of biomedical researchers. It is widely used in various tissue engineering, such as skin wound healing, bone and cartilage tissue engineering, blood vessel and nerve regeneration. However, there are many problems in transforming basic research into clinical application, such as: which extraction method is more fast and efficient for fish skin collagen factory production; and which functional modification scheme for fish skin collagen to achieve composite construction of grafts; the standard of how to improve the mechanical properties and degradation properties of fish skin collagen-based materials to support the regeneration and repair of bone and cartilage tissue; how to construct scaffold materials to improve the perfect and rapid repair of skin trauma.

Key words: fish skin collagen, tissue engineering, extraction, modification, bone tissue engineering, cartilage tissue engineering, skin tissue engineering, biomedical applications

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