中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (18): 2934-2639.doi: 10.3969/j.issn.2095-4344.2017.18.023

• 生物材料综述 biomaterial review • 上一篇    下一篇

国内外胰管支架材料发展状况及临床应用

王江,刘凯   

  1. 吉林大学第一医院肝胆胰外二科,吉林省长春市  130021
  • 收稿日期:2017-05-08 出版日期:2017-06-28 发布日期:2017-07-07
  • 通讯作者: 刘凯,副教授,硕士生导师,吉林大学第一医院肝胆胰外二科,吉林省长春市 130021
  • 作者简介:王江,男,1991年生,黑龙江省牡丹江市人,汉族,吉林大学在读硕士,主要从事肝胆胰脾相关疾病的研究。
  • 基金资助:

    吉林省发改委资助(2013C023-6)

Current development and clinical application of pancreatic stents

Wang Jiang, Liu Kai   

  1. Department of Hepatobiliary and Pancreatic Surgery, No. 1 Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • Received:2017-05-08 Online:2017-06-28 Published:2017-07-07
  • Contact: Liu Kai, Associate professor, Master’s supervisor, Department of Hepatobiliary and Pancreatic Surgery, No. 1 Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • About author:Wang Jiang, Studying for master’s degree, Department of Hepatobiliary and Pancreatic Surgery, No. 1 Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • Supported by:

    a grant from the Jilin Provincial Development and Reform Commission, No. 2013C023-6

摘要:

文章快速阅读:

 

文题释义:
内镜下支架置入术
:该手术已成为治疗慢性胰腺炎的有效措施,其术后疗效与胰管支架材料的选择密切相关,因此胰管支架材料的选择及开发已成为临床研究的热点问题。合适的支架材料可优化手术操作,改善临床疗效,但目前各种支架材料存在相应的弊端,其影响了胰管支架的临床应用。随着新型胰管支架材料的研究,相关难题逐步得到解决,内镜下胰管支架置入术有望在临床中得到质的飞跃。
慢性胰腺炎:各种病因引起胰腺组织和功能不可逆改变的慢性炎症性疾病。基本病理特征包括胰腺实质慢性炎症损害和间质纤维化、胰腺实质钙化、胰管扩张及胰管结石等改变。临床主要表现为反复发作的上腹部疼痛和胰腺内、外分泌功能不全。


背景:近年来,随着人们饮食习惯和生活习惯的改变,慢性胰腺炎发病率显著增高,内镜下胰管支架治疗慢性胰腺炎展现出良好的临床前景。
目的:介绍各种支架材料的利弊,阐述国内外胰管支架材料发展状况及临床应用。
方法:以“慢性胰腺炎,胰管支架”为中文检索词,以“chronic pancreatitis,pancreatic stent” 为英文检索词,应用计算机在中国期刊全文数据库和 PubMed数据库检索 2005年1月至 2016年11月的相关文章,筛选出可用于体内外及临床研究的内镜下新型材料胰管支架。
结果与结论:①内镜下胰管支架置入作为慢性胰腺炎的有效治疗手段之一,已成为国内外专家的共识,其中胰管支架材料的开发和应用显得尤为重要;②根据胰管支架材料的不同,可将胰管支架分为塑料支架、自膨胀金属支架、具有生物可降解性的支架;③塑料胰管支架与自膨胀金属胰管支架虽已广泛应用于临床,但其存在支架与胰管契合度欠佳、支架移位且需二次手术取出等问题;④生物可降解性的支架材料可在预期时间内于胰管中完全降解,避免了支架置入术后的诸多并发症。故具有生物可降解性的支架材料的开发及应用已成为国内外专家的研究热点。

ORCID: 0000-0002-1981-1386(王江)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 生物材料, 材料相容性, 慢性胰腺炎, 经内镜逆行性胰胆管造影术, 胰管支架, 生物可降解材料

Abstract:

BACKGROUND: In recent years, the morbidity of chronic pancreatitis has been increasing dramatically with lifestyle changes. Fortunately, endoscopic pancreatic stenting for patients with chronic pancreatitis shows favorable clinical prospects.
OBJECTIVE: To introduce the advantages and disadvantages of various stent materials and to review the development and clinical application of pancreatic stents.
METHODS: With the key words of “chronic pancreatitis, pancreatic stent” in Chinese and English, respectively, a computer-based search was performed for articles published in CNKI and PubMed databases from January 2005 to November 2016. After the initial screening, articles related to endoscopic pancreatic stenting used in vitro, in vivo or in clinic were included.
RESULTS AND CONCLUSION: Endoscopic pancreatic stenting has become a recognized treatment for chronic pancreatitis in recent years. Therefore, the development and application of the materials of pancreatic duct stents appear to be particularly important. According to different materials, pancreatic duct stents can be classified into plastic stents, fully covered self-expandable metal stents, and biodegradable stents. The complications, including stent migration and secondary surgery, frequently appear in the clinical use of plastic pancreatic duct stents and self-expandable metal stents, although they have been widely used in clinical practice. Biodegradable pancreatic duct stents can be degraded completely in the pancreatic duct within the expected time, and thereby avoid several complications. Consequently, the exploitation and application of biodegradable pancreatic duct stents have become an issue of concern.

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Pancreatitis, Chronic, Cholangiography, Stents, Tissue Engineering

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