中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (2): 296-301.doi: 10.3969/j.issn.2095-4344.2017.02.024

• 生物材料综述 biomaterial review • 上一篇    下一篇

硅在生物材料领域的应用:增加材料生物活性不影响其机械性能

章筛林,成翔宇,纪  斌
  

  1. 上海中医药大学附属普陀医院骨科,上海市  200062
  • 收稿日期:2016-10-19 出版日期:2017-01-18 发布日期:2017-02-27
  • 通讯作者: 纪斌,主任医师,硕士生导师,上海中医药大学附属普陀医院骨科,上海市 200062
  • 作者简介:章筛林,男,1977年生,汉族,2013年苏州大学毕业,博士,主治医师,主要从事脊柱外科、关节外科、创伤骨科的研究。
  • 基金资助:

    上海市普陀区卫生系统自主创新项目(2013PTKW015)

Application of silicon in biomaterials: an increase in bioactivity but with no change in mechanical performance

Zhang Shai-lin, Cheng Xiang-yu, Ji Bin
  

  1. Department of Orthopaedics, Affiliated Putuo Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
  • Received:2016-10-19 Online:2017-01-18 Published:2017-02-27
  • Contact: Ji Bin, Chief physician, Master’s supervisor, Department of Orthopaedics, Affiliated Putuo Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
  • About author:Zhang Shai-lin, M.D., Attending physician, Department of Orthopaedics, Affiliated Putuo Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
  • Supported by:
    the Self-Innovation Project of Health System in Shanghai Putuo District, No. 2013PTKW015

摘要:

文章快速阅读

 

文题释义:
45S5生物活性玻璃
:由Hench教授在1971年研制出的一种Na-Ca-Si系玻璃,该种玻璃植入人体后,能与生物环境发生一系列特殊的表面反应,使材料与自然组织形成牢固的化学键结合而具有生物活性。一般Bioglass代指组成为45S5的生物活性玻璃。45S5生物活性玻璃的组成(质量分数):Na2O 24.5%,  CaO 24.5%,P2O5 6.0%,SiO2 45%。45S是指45%质量分数的SiO2,5表示Ca和P的摩尔比为5∶1。
硅酸盐:指的是硅、氧与其他化学元素(主要是铝、铁、钙、镁、钾、钠等)结合而成的化合物的总称。它在地壳中分布极广,是构成多数岩石(如花岗岩)和土壤的主要成分。

背景:硅在骨骼发育中具有重要作用,生物活性硅酸盐玻璃是当今生物活性材料研究的热点。利用硅的生物学作用,已研制出各种不同的生物材料。
目的:探讨硅的生物学功能和含硅生物材料的研究进展。
方法:检索中国期刊全文数据库、PubMed、SpringerLink、Elsevier ScienceDirect数据库,查找关于硅的生物学作用和在生物材料领域应用的相关文献,对资料进行筛选,排除重复研究和关联性较小的文献,保留与硅在生物材料领域应用关联性较大的文献。
结果与结论:共纳入68篇符合标准的英文文献。经分析得出:骨骼中的硅具有重要的化学和生物学作用。细胞外基质中的硅可在糖胺聚糖和蛋白聚糖合成过程中与它们相互作用,并在羟基磷灰石晶体的晶格结构中形成离子取代。此外,生物活性玻璃溶解产物(主要是硅酸)对体外成骨细胞分子生物学有显著影响,可调节多种基因,包括重要的成骨细胞标志物、细胞周期调控因子和细胞外基质蛋白的基因表达。硅已被证实能够增加各种材料的生物活性,且不影响他们的机械性能或诱导细胞毒性。

关键词: 生物材料, 材料相容性, 硅, 羟基磷灰石, 生物活性玻璃, 硅酸盐, 多孔硅

Abstract:

BACKGROUND: Silicon plays an essential role in bone development and bioactive silicate glasses pioneered the current era of bioactive materials. Various biomaterials have been developed based on the biological function of silicon.
OBJECTIVE: To explore the biological function of silicon and research process of silicon in biomaterials.
METHODS: A computer-based retrieval of CNKI, PubMed, SpringerLink and Elsevier ScienceDirect databases was performed to search the relevant literatures concerning the biological function of silicon and its application in biomaterials. All data were primarily screened to exclude repeated and irrelevant articles. Literatures about the application of silicon in biomaterials were included.
RESULTS AND CONCLUSION: A total of 68 eligible English articles are enrolled. Silicon plays important chemical and biological roles in bone. Silicon in the extracellular matrix interacts with glycosaminoglycans and proteoglycans during their synthesis and form ionic substitutions in the crystal lattice structure of hydroxyapatite. In addition, the dissolution products of bioactive glass (mainly silicic acid) expose significant influence on the molecular biology of osteoblasts in vitro, and can regulate the expressions of several genes including osteoblastic markers, cell cycle regulators and extracellular matrix proteins. Silicon has been proved to improve the bioactivity of numerous materials and do no harm to their mechanical properties and without cytotoxicity.  

Key words: Silicon, Hydroxyapatite, Silicates, Tissue Engineering

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