中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (5): 716-720.doi: 10.3969/j.issn.2095-4344.2015.05.011

• 器官移植动物模型 organ transplantation and animal model • 上一篇    下一篇

镜像疗法治疗高位脊髓损伤后上肢Ⅱ型复杂性局部疼痛综合征的有效性：自身交叉对照研究

唐朝正1，丁  政2，张晓莉1，丁  力1，吴  毅1，贾  杰1   

  1. 1复旦大学附属华山医院康复科，上海市  200040
    2福建中医药大学，福建省福州市  350000
  • 修回日期:2014-10-22 出版日期:2015-01-30 发布日期:2015-03-02
  • 通讯作者: 贾杰，博士，副教授，硕士生导师，复旦大学附属华山医院康复医学科，上海市 200040
  • 作者简介:唐朝正，男，1990年生，贵州省遵义市人，汉族，2013年温州医科大学毕业，硕士，主要从事脑卒中后手功能障碍的康复治疗。
  • 基金资助:

    十二五”国家科技支撑手功能项目(2013BAI10B03)；国家自然科学基金项目(90920014，91120305)，上海市科委生物医药重点项目(13411951000)

Effect of mirror therapy on complex regional pain syndrome (type II) after high-level spinal cord injury: a self cross-controlled study

Tang Chao-zheng1, Ding Zheng2, Zhang Xiao-li1, Ding Li1, Wu Yi1, Jia Jie1   

  1. 1Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
    2Fujian University of Traditional Chinese Medicine, Fuzhou 350000, Fujian Province, China
  • Revised:2014-10-22 Online:2015-01-30 Published:2015-03-02
  • Contact: Jia Jie, M.D., Associate professor, Master’s supervisor, Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
  • About author:Tang Chao-zheng, Master, Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Supported by:

    The Twelfth Five-year Plan Supporting Project of Ministry of Science and Technology of China, No. 2013BAI10B03; the National Natural Science Foundation of China, No. 90920014, 91120305; and the Key Projects of Shanghai Municipal Science and Technology Committee on Biomedicine, No. 13411951000

PDF

766

摘要：

背景：镜像疗法最早用于截肢术后患肢痛的治疗，研究显示该疗法对其他损伤引起的复杂性局部疼痛综合征有效，但针对高位脊髓损伤后3年余的上肢复杂性局部疼痛综合征患者还未见报道。
目的：探讨镜像疗法对高位脊髓损伤后上肢Ⅱ型复杂性局部疼痛综合征患者疼痛缓解的有效性。
方法：采用自身交叉对照的试验设计分别应用经皮电神经刺激、镜像盒对该高位脊髓损伤后上肢Ⅱ型复杂性局部疼痛综合征的患者进行为期2周和3周的疼痛治疗，2种干预手段之间的洗脱期为1周，随访时间为1个月。
结果与结论：前2周的经皮电神经刺激治疗患者疼痛没有实质性缓解，甚至一度加重，而洗脱期(第3周)后经过3周的镜像治疗，患者的疼痛感受明显减轻；其汉密尔顿焦虑量表、汉密尔顿抑郁量表、世界卫生组织生活质量量表评分也较治疗前明显改善。表明镜像疗法作为复杂性局部疼痛综合征综合治疗的补充，可能是一种有效地减轻Ⅱ型复杂性局部疼痛综合征疼痛的康复手段，但仍需进一步研究来确证其疗效。



中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程


全文链接：

关键词: 脑及脊髓损伤模型, 上肢, Ⅱ型复杂性局部疼痛综合征, 神经病理性疼痛, 颈髓损伤, 镜像疗法, 经皮电神经刺激, 作业疗法, 康复, 国家自然科学基金

Abstract:

BACKGROUND: Mirror therapy was initially used in the treatment of affected limb pain after amputation, and has been applied as a valid way for relieving complex regional pain syndrome due to other injuries, but the efficacy for patients with upper limb complex regional pain syndrome (type II) more than 3 years after high-level spinal cord injury has not been reported in any way.
OBJECTIVE: To investigate the availability of mirror therapy for reducing pain in a patient with upper limb complex regional pain syndrome (type II) who suffered high-level spinal cord injury.
METHODS: An experimental design of self cross-control was applied for alleviating the patient’s pain with the intervention of transcutaneous electrical nerve stimulation and mirror box therapy, which were conducted 2 or 3 weeks respectively. And the elution period between two kinds of treatments was 1 week, the follow-up time was 1 month.
RESULTS AND CONCLUSION: The pain of the patient was not relieved, but even aggravated after 2 weeks of transcutaneous electrical nerve stimulation, while 3-week mirror box therapy significantly reduced the pain after elution period (the third week). The Hamilton anxiety scale, Hamilton depression scale, and WHO quality of life scale scores were significantly improved after treatment compared with before treatment. Experimental findings indicate that, mirror therapy may be an effective intervention for mitigating complex regional pain syndrome (type  II) in addition to the comprehensive treatments, but further studies are warranted to confirm its effect.



中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程


全文链接：

Key words: Complex Regional Pain Syndrome, Spinal Cord Injuries, Transcutaneous Electrical Nerve Stimulation, Rehabilitation

中图分类号: