中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (49): 9265-9270.doi: 10.3969/j.issn.2095-4344.2012.49.026

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞移植治疗脊髓损伤的途径及联合方式

张 达，屠冠军

   

  1. 中国医科大学附属第一医院骨科，辽宁省沈阳市 110001
  • 收稿日期:2012-04-10 修回日期:2012-05-10 出版日期:2012-12-02 发布日期:2012-12-02
  • 通讯作者: 屠冠军，博士，教授，主任医师，中国医科大学附属第一医院骨科，辽宁省沈阳市 110001
  • 作者简介:张达★，男，1984年生，辽宁省沈阳市人，汉族，中国医科大学在读硕士，医师，主要从事脊柱损伤方面研究。zhangda_333@126.com

Bone marrow mesenchymal stem cell transplantation for experimental spinal cord injury: transplantation routes and combination modes

Zhang Da, Tu Guan-jun   

  1. Department of Orthopedics, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
  • Received:2012-04-10 Revised:2012-05-10 Online:2012-12-02 Published:2012-12-02
  • Contact: Tu Guan-jun, M.D., Professor, Chief physician, Department of Orthopedics, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
  • About author:Zhang Da★, Studying for master’s degree, Physician, Department of Orthopedics, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China zhangda_333@126.com

PDF

510

被引次数

6

摘要：

背景：不同途径移植骨髓间充质干细胞后脊髓损伤的功能恢复程度存在较大差异，并且单纯的骨髓间充质干细胞移植对脊髓损伤的修复作用并不理想。
目的：综述骨髓间充质干细胞修复实验性脊髓损伤的移植途径及联合治疗方式。
方法：由第一作者检索1995年1月至2011年12月 CNKI数据库和Pubmed数据库相关文献。中文检索词为“骨髓间充质干细胞，细胞移植，脊髓损伤，移植途径，联合方式”；英文检索词为“Bone marrow mesenchymal stem cells，cellular transplant，spinal cord injury，explantation channel，modality alliance”。最终选择47篇文献进行综述。
结果与结论：细胞移植治疗脊髓损伤的途径方法很多，如：损伤局部移植、经脑脊液移植、静脉移植、腹腔移植及组织工程支架移植等。组织工程支架移植效果最佳，其次是损伤原位移植、经脑脊液移植，经静脉和腹腔移植效果较差。骨髓间充质干细胞联合生物工程材料、药物、物理等手段移植治疗脊髓损伤已经得到广泛学者的认可，但对于不同损伤时间、损伤方式和损伤程度移植治疗方案需要进一步规范和评估。

关键词: 骨髓间充质干细胞, 细胞移植, 脊髓损伤, 移植途径, 联合方式

Abstract:

BACKGROUND: Different ways of bone marrow mesenchymal stem cells transplantation produce different degrees of functional recovery of spinal cord injury. Transplantation of simple bone marrow mesenchymal stem cells yields unsatisfactory efficacy in recovery of spinal cord injury.
OBJECTIVE: To review the transplantation routes and combination modes regarding bone marrow mesenchymal stem cells transplantation for the treatment of experimental spinal cord injury.
METHODS: A computer-based online retrieval was performed by the first author in CNKI and PubMed databases to search papers published during 1995-01/2011-12 with the key words “ bone marrow mesenchymal stem cells, cellular transplant, spinal cord injury, explanation channel, modality alliance” in Chinese and English. Forty-seven papers were included in the final analysis.
RESULTS AND CONCLUSION: There are many transplantation routes used for cell transplantation for the treatment of spinal cord injury, including in situ transplantation, transplantation via the cerebrospinal fluid, intravenous transplantation, transplantation via the abdominal cavity and tissue engineering scaffold. The tissue engineering scaffold method produces optimal efficacy, followed by in situ transplantation and transplantation via the cerebrospinal fluid, and the efficacy of intravenous transplantation and transplantation via the abdominal cavity is poor. Bone marrow mesenchymal stem cells combined with other ways of transplantation in the treatment of spinal cord injury has been widely recognized by scholars, but the treatment schemes of spinal cord injury targeting different injury times, patterns and extents need to be further standardized and assessed.

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