中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (37): 6902-6905.doi: 10.3969/j.issn.2095-4344.2012.37.013

• 组织构建与生物力学 tissue construction and biomechanics • 上一篇    下一篇

老龄化自发性高血压模型大鼠与SD大鼠左冠状动脉蠕变特性的比较

于 波，高 明，李新颖   

  1. 吉林大学中日联谊医院，吉林省长春市 130031
  • 收稿日期:2011-12-31 修回日期:2012-01-31 出版日期:2012-09-09 发布日期:2012-09-09
  • 作者简介:于波★，男，1969年生，吉林省长春市人，汉族，2004年吉林大学毕业，硕士，副主任医师，主要从事心内科临床与生物力学的研究。 mahs@jlu.edu.cn

Creep properties of the left coronary artery in aging spontaneously hypertensive rats versus Sprague Dawley rats

Yu Bo, Gao Ming, Li Xin-ying   

  1. China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin Province, China
  • Received:2011-12-31 Revised:2012-01-31 Online:2012-09-09 Published:2012-09-09
  • About author:Yu Bo★, Master, Associate chief physician, China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin Province, China mahs@jlu.edu.cn

PDF

362

被引次数

3

摘要：

背景：国内关于老龄高血压模型动物左冠状动脉一维拉伸力学性质鲜有报道。
目的：观察SD大鼠和老龄自发性高血压大鼠左冠状动脉的蠕变特性。
方法：在日本岛津电子万能试验机上对4月龄SD大鼠和老龄(12月龄)自发性高血压大鼠左冠状动脉进行蠕变实验，模拟人体温在(36.5±0.1) ℃的温度场下以0.05%/s的应变增加速度对试样施加应力，设定时间为7 200 s。
结果与结论：两组试样蠕变曲线是以指数关系变化的，在最初600 s应变变化较快，随时间延长应变缓慢上升，SD组大鼠试样7 200 s应应变上升量大于自发性高血压组，差异有显著性意义(P < 0.05)。提示正常SD大鼠左冠状动脉和老龄自发性高血压大鼠左冠状动脉具有不同蠕变特性。

关键词: 自发性高血压, SD大鼠, 冠状动脉, 蠕变, 特性, 组织构建

Abstract:

BACKGROUND: Reports about one-dimension tensile property of the left coronary artery in aging spontaneously hypertensive animal models are few in China.
OBJECTIVE: To observe creep properties of left coronary artery in aging spontaneously hypertensive rats and Sprague Dawley rats.
METHODS: Twelve normal male Sprague Dawley rats (4 months old) and 12 aging spontaneously hypertensive male rats (12 months old) were selected and divided into normal Sprague Dawley group and spontaneously hypertensive group. Twelve samples from each group were selected and installed in electronic testing machine for the creep test, and they were given stress by 0.05%/s strain increases velocity at the simulating human body temperature of (36.5±0.1) ℃. The setting time was 7 200 seconds. Creep equations of these samples in the two groups were calculated by normalized analysis method.
RESULTS AND CONCLUSION: Creep curves of the two groups were changed in exponential relationship. In the initial 600 seconds, the strain changed rapidly, and it rose slowly as time prolonged. The strain increment in 7 200 seconds of normal Sprague Dawley group was more than that of spontaneously hypertensive group. There was a significant difference between the two groups (P < 0.05). It suggests that there are differences in creep properties of the left coronary artery between normal Sprague Dawley rats and aging spontaneously hypertensive rats.

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