中国组织工程研究

中国组织工程研究 ›› 2020, Vol. 24 ›› Issue (2): 187-191.doi: 10.3969/j.issn.2095-4344.1914

• 软骨组织构建 cartilage tissue construction • 上一篇    下一篇

含裂纹缺损关节软骨的单轴准静态拉伸性能

司雲朋1，2，高丽兰1，2，张春秋1，2，彭宇霖3   

  1. 1天津理工大学天津市先进机电系统设计与智能控制重点实验室，天津市  300384；2机电工程国家级实验教学示范中心(天津理工大学)，天津市  300384；3北京北方华创微电子装备有限公司第二刻蚀事业部，北京市  100176
  • 收稿日期:2019-05-23 修回日期:2019-05-28 接受日期:2019-06-29 出版日期:2020-01-18 发布日期:2019-12-25
  • 通讯作者: 高丽兰，博士，教授，天津理工大学，天津市先进机电系统设计与智能控制重点实验室，天津市 300384；机电工程国家级实验教学示范中心(天津理工大学)，天津市 300384
  • 作者简介:司雲朋，男，1994年生，河北省石家庄市人，汉族，天津理工大学在读硕士，主要从事生物力学方向的研究。
  • 基金资助:
    国家自然科学基金项目(11572222)；国家自然科学基金项目(11672208)；天津市自然科学基金重点项目(18JCZDJC36100)

Uniaxial quasi-static tensile properties of articular cartilage with crack defects

Si Yunpeng1, 2, Gao Lilan1, 2, Zhang Chunqiu1, 2, Peng Yulin3   

  1. 1Key Laboratory of Advanced Electromechanical System Design and Intelligent Control, Tianjin University of Technology; 2National Experimental Teaching Demonstration Center of Mechatronics Engineering, Tianjin University of Technology; 3the Second Etching Division, Beijing North Huachuang Microelectronics Equipment Co., Ltd.
  • Received:2019-05-23 Revised:2019-05-28 Accepted:2019-06-29 Online:2020-01-18 Published:2019-12-25
  • Contact: Gao Lilan, PhD, Professor, Key Laboratory of Advanced Electromechanical System Design and Intelligent Control, Tianjin University of Technology, Tianjin 300384, China; National Experimental Teaching Demonstration Center of Mechatronics Engineering, Tianjin University of Technology, Tianjin 300384, China
  • About author:Si Yunpeng, Master candidate, Key Laboratory of Advanced Electromechanical System Design and Intelligent Control, Tianjin University of Technology, Tianjin 300384, China; National Experimental Teaching Demonstration Center of Mechatronics Engineering, Tianjin University of Technology, Tianjin 300384, China
  • Supported by:
    the National Natural Science Foundation of China, No. 11572222 and 11672208; the Key Project of the Natural Science Foundation of Tianjin, No. 18JCZDJC36100

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摘要：

文题释义：

关节软骨：是由高度特异性的软骨细胞和大量细胞外基质组成，无血管、无神经的一种覆盖在软骨下骨表面的结缔组织，表面光滑，富有弹性，负责骨与骨之间的功能性联结，能够传递载荷、缓冲震荡并维持日常活动。

蠕变：是指材料在恒定应力水平下随时间的推移应变增加的现象。与塑性变形不同的是，塑性变形通常在应力超过弹性极限之后才出现，而蠕变只要应力的作用时间足够长，它在应力小于弹性极限施加的力时也能出现。

背景：关节软骨一旦出现裂纹缺损其力学性能会发生改变，而先前研究中针对受损关节软骨的探究多集中在压缩，对于拉伸性能的研究较少。

目的：预先在软骨层试样上制造裂纹缺损，测试其单轴准静态拉伸性能。

方法：选取新鲜成年猪膝关节的关节软骨，制备含裂纹缺损的软骨试样，在不同应力率下(0.001，0.01，和0.1 MPa/s)测试其拉伸性能，在不同恒定应力下(1，2，3 MPa)测试其蠕变性能。

结果与结论：①不同应力速率下的拉伸实验中，随着应力速率的增加，达到相同应变所需的应力逐渐增大，且试件的杨氏模量随应力率的增加而增加；②不同应力速率下含裂纹缺损关节软骨的拉伸应力-应变曲线不重合，说明含裂纹缺损关节软骨的拉伸性能具有率相关性；③不同恒定拉应力水平下的蠕变实验中，蠕变应变随着拉应力水平的提高而增大，蠕变柔量随拉应力水平的提高而降低，并且随着蠕变时间的推移蠕变应变先快速增加后缓慢增加；④结果表明，不同应力率和不同恒定应力对含裂纹缺损关节软骨的拉伸力学性能影响较大，该实验结果可为缺损关节软骨的修复提供力学参考。

ORCID: 0000-0002-7288-6686(高丽兰)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


关键词: 裂纹缺损, 关节软骨, 单轴拉伸, 应力速率, 恒定应力, 蠕变, 生物力学, 组织工程

Abstract:

BACKGROUND: Once the articular cartilage has a crack defect, its mechanical properties will change. In previous studies, the investigation of damaged articular cartilage mostly focused on compression, and there were few studies on tensile properties.

OBJECTIVE: To measure the uniaxial quasi-static tensile properties by preparing crack defects on the cartilage layer samples.

METHODS: The articular cartilage of the fresh adult pig knee joint was selected to prepare a cartilage specimen containing a crack defect. The tensile properties were tested at different stress rates (0.001, 0.01 and 0.1 MPa/s) and the creep properties were tested under different constant stresses (1, 2 and 3 MPa).

RESULTS AND CONCLUSION: (1) In the tensile test at different stress rates, as the stress rate increases, the stress required to reach the same strain increased gradually, and the Young’s modulus of the test piece increases with the increase of the stress rate. (2) The tensile stress-strain curves of the articular cartilage with cracks at different stress rates did not coincide, indicating that the tensile properties of the articular cartilage with crack defects are rate-dependent. (3) In the creep experiment under different constant tensile stress levels, the creep strain increased with the increase of the tensile stress level, the creep compliance decreased with the increase of the tensile stress level, and with the creep time. The creep strain increased rapidly and then increased slowly. (4) To conclude, different stress rates and different constant stresses have great influence on the tensile mechanical properties of articular cartilage with crack defects. The experimental results provide a mechanical reference for the repair of defective articular cartilage.

Key words: crack defect, articular cartilage, uniaxial stretching, stress rate, constant stress, creep, biomechanics, tissue engineering

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