中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (30): 5586-5590.doi: 10.3969/j.issn.2095-4344.2012.30.016

• 骨与关节临床实践 clinical practice of the bone and joint • 上一篇    下一篇

前列腺素E2在闭合性单纯性长骨干骨折患者急性疼痛中的作用

丁洋洋，丁呈彪，张建湘，汤 建，彭 磊   

  1. 安徽医科大学第一附属医院骨3科，安徽省合肥市 230022
  • 收稿日期:2012-04-01 修回日期:2012-05-14 出版日期:2012-07-22 发布日期:2012-07-22
  • 通讯作者: 张建湘，硕士，主任医师，教授，硕士生导师，安徽医科大学第一附属医院骨3科，安徽省合肥市 230022 282261913@qq.com
  • 作者简介:丁洋洋★，男，1987年生，安徽省巢湖市人，汉族，安徽医科大学在读硕士，主要从事脊柱外科、骨折创伤诊治工作。 282261913@qq.com

Effect of prostaglandin E2 on the acute pain of the patients with simple closed long bone fracture

Ding Yang-yang, Ding Cheng-biao, Zhang Jian-xiang, Tang Jian, Peng Lei   

  1. Third Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
  • Received:2012-04-01 Revised:2012-05-14 Online:2012-07-22 Published:2012-07-22
  • Contact: Tang Jian, Chief physician, Professor, Master’s supervisor, Third Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China 282261913@qq.com
  • About author:Ding Yang-yang★, Studying for master’s degree, Third Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China 282261913@qq.com

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摘要：

背景：前列腺素E2含量增多可直接引起疼痛或增加神经根对缓激肽等致痛物质的敏感性，使神经根痛阈下降引起疼痛。
目的：观察前列腺素E2在急性骨折导致的急性疼痛中所起的作用。
方法：单纯急性闭合性长骨干骨折所致急性疼痛症状住院患者，采取静脉滴注非类固醇类抗炎药类镇痛药氟比洛芬酯注射液进行镇痛治疗。于治疗前后分别采用目测类比评分评价患者疼痛程度，测定血浆中前列腺素水平。
结果与结论：患者用药前30 min及用药后6 h血浆前列腺素E2浓度和目测类比评分明显高于用药后2 h(P < 0.05)。证实，前列腺素E2与闭合性单纯性长骨干骨折患者急性疼痛密切相关，采用镇痛药物抑制前列腺素E2浓度可有效减轻患者疼痛。

关键词: 氟比洛芬酯, 前列腺素E2, 骨折后疼痛, 镇痛, 目测类比评分, 植入物

Abstract:

BACKGROUND: The accumulation of prostaglandin E2 can cause the pain and increase the sensitivity of pain producing substance, such as the bradykinin, and decrease the pain threshold of the nerve root and cause the pain.
OBJECTIVE: To observe the effect of prostaglandin E2 in the acute pain caused by acute fracture.
METHODS: The patients with acute pain symptoms caused by simple acute closed long bone fracture received the analgesic treatment by intravenous injection of non-steroidal anti-inflammatory analgesics drug (intravenous flurbiprofen axetil injection). The pain visual analogous scale score was used to measure the pain scores before and after treatment, and the prostaglandins levels of the blood samples were measured.
RESULTS AND CONCLUSION: The visual analog scale score and the level of prostaglandin E2 at 30 minutes before medication and 6 hours after medication were significantly higher than those at 2 hours after medication (P < 0.05). It confirmes that prostaglandin E2 plays an important role in the treatment of acute pain caused by simple acute closed long bone fracture, active use of analgesic drugs that inhibit the prostaglandin levels can effectively control the pain.

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