中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (6): 963-970.doi: 10.3969/j.issn.2095-4344.1553

• 生物材料综述 biomaterial review • 上一篇    下一篇

生物活性支架在骨组织工程中的应用及进展

冷 一,李祖浩,任广凯,王中汉,高超华,史晨玉,刘 贺,吴丹凯   

  1. 吉林大学第二医院骨科,吉林省长春市 130041
  • 收稿日期:2018-11-06 出版日期:2019-02-28 发布日期:2019-02-28
  • 通讯作者: 吴丹凯,主任医师,教授,硕士生导师,吉林大学第二医院骨科,吉林省长春市 130041
  • 作者简介:冷一,男,1996 年生,汉族,吉林大学第二医院骨科在读硕士,主要从事骨组织工程支架及骨缺损临床治疗的研究。
  • 基金资助:

    国家自然科学基金(81671804,81171681,81772456)

Application and progress of bioactive scaffolds in bone tissue engineering

Leng Yi, Li Zuhao, Ren Guangkai, Wang Zhonghan, Gao Chaohua, Shi Chenyu, Liu He, Wu Dankai   

  1. Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Received:2018-11-06 Online:2019-02-28 Published:2019-02-28
  • Contact: Wu Dankai, Chief physician, Professor, Master’s supervisor, Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • About author:Leng Yi, Master candidate, Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81671804, 81171681 and 81772456

摘要:

文章快速阅读:

 

文题释义:
生物活性支架:具有三维结构的骨组织工程支架,既可填充骨缺损,提供必要的机械强度,具有良好的生物相容性和多孔结构,可为骨细胞提供附着,又可搭载抗骨质疏松药物,对修复骨缺损起积极作用。
溶剂浇铸/颗粒浸出技术:具体方法是将致孔剂与目标材料溶液混合,随后即形成聚合物-致孔剂网络。复合物中溶剂蒸发,使支架硬化,随后用水溶解致孔剂,形成了具有孔隙的支架。此种制作方法有着相对简单的技术,可形成具有规则孔隙率、孔径的支架。
 
 
背景:随着生物打印技术与化学合成技术的进展,将这些技术纳入组织工程支架制作,用于促进骨再生已成为当今研究的热点。
目的:介绍生物活性骨组织工程支架,讨论并总结不同制作材料在促进骨再生及治疗骨缺损方面的应用。
方法:由第一作者于2018年7至9月以“bone tissue engineer,3D-printed,scaffold,composite scaffold”为关键词,检索2003至2018年期间PubMed、Web of Science、SpringerLink、Medline数据库发表的相关文献。初检文章237篇,筛选后对70篇文章进行分析。

结果与结论:生物活性支架主要包括金属材料复合支架、生物陶瓷材料复合支架与聚合物材料复合支架,目前已被应用于骨组织工程中。已开发了几个具有临床转化成功的骨和软骨构建体实例,其中陶瓷和聚合物复合材料与天然骨具有相似的组织组成和良好的生物相容性,可能获得最大成功。若可将现有的生物活性材料、生长因子、功能化技术和仿生支架设计相结合,在未来可能为特定患者创建复杂的骨组织工程支架,这也为治疗各种具有挑战性的疾病提供了希望,包括骨肿瘤、骨质疏松症和严重的骨缺损。

ORCID: 0000-0002-2494-4677(冷一)

 

关键词: 骨科材料, 生物活性材料, 3D打印, 骨缺损, 骨再生, 仿生支架, 功能化技术

Abstract:

BACKGROUND: With the advancement of bio-printing technology and chemical synthesis technology, the incorporation of these technologies into tissue engineering scaffolds for promoting bone regeneration has become a hot topic in current research.

OBJECTIVE: To introduce bioactive bone tissue engineering scaffolds, and to discuss and summarize the application of different scaffold materials in promoting bone regeneration and treating bone defects.
METHODS: The first author searched PubMed, Web of Science, SpringerLink, and Medline databases in July to September 2018 for relevant articles published from 2003 to 2018 using the keywords of “bone tissue engineer,3D-printed, scaffold, composite scaffold”. Initially, 237 articles were retrieved, and only 70 articles were eligible for result analysis.

RESULTS AND CONCLUSION: Bioactive scaffolds mainly include metal composite scaffolds, bioceramic composite scaffolds and polymer composite scaffolds, which have been used in bone tissue engineering. Several examples of successful bone and cartilage construction with clinical transformation have been developed, in which bioceramic and polymer composites may be the most successful due to their similar tissue composition and good biocompatibility with natural bone. And if combined with existing bioactive materials, growth factors, functionalization techniques and biomimetic scaffold designs, the potential for creating complex bone tissue engineering scaffolds for patient-specific applications in the future is enormous. This also provides hope for the treatment of a variety of challenging diseases, including bone tumor, osteoporosis and severe bone defects. 

Key words: Bone Regeneration, Polymers, Tissue Engineering

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