中国组织工程研究

中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (23): 3760-3766.doi: 10.3969/j.issn.2095-4344.1325

• 组织构建综述 tissue construction review • 上一篇    下一篇

槲皮素在创伤性脑损伤治疗中潜在分子机制和临床应用的可行性

黄  超1，黄庆华2，尤  荻3，郭文来1，瞿文瑞1，朱  哲1，李  锐1   

  1. (1吉林大学第二医院手外科，吉林省长春市  130022；2大庆龙南医院专家门诊，黑龙江省大庆市   163453；3吉林大学中日联谊医院麻醉科，吉林省长春市  130033)
  • 收稿日期:2019-03-18 出版日期:2019-08-18 发布日期:2019-08-18
  • 通讯作者: 李锐，博士，教授，吉林大学第二医院手外科，吉林省长春市 130022 并列通讯作者：朱哲，博士，主治医师，吉林大学第二医院手外科，吉林省长春市 130022
  • 作者简介:黄超，男，1992年生，四川省都江堰市人，汉族，吉林大学第二医院在读硕士，医师，主要从事臂丛神经撕脱伤，创伤性脑损伤等方面的研究。
  • 基金资助:

    吉林省科技发展计划项目(20180101118JC)，项目负责人：李锐

Molecular mechanism of quercetin in the treatment of traumatic brain injury: its feasibility of clinical application

Huang Chao1, Huang Qinghua2, You Di3, Guo Wenlai1, Qu Wenrui1, Zhu Zhe1, Li Rui1   

  1. (1Department of Hand Surgery, the Second Hospital of Jilin University, Changchun 130022, Jilin Province, China; 2Specialist Clinic, Daqing Longnan Hospital, Daqing 163453, Heilongjiang Province, China; 3Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China)
  • Received:2019-03-18 Online:2019-08-18 Published:2019-08-18
  • Contact: Li Rui, MD, Professor, Department of Hand Surgery, the Second Hospital of Jilin University, Changchun 130022, Jilin Province, China Corresponding author: Zhu Zhe, MD, Attending physician, Department of Hand Surgery, the Second Hospital of Jilin University, Changchun 130022, Jilin Province, China
  • About author:Huang Chao, Master candidate, Physician, Department of Hand Surgery, the Second Hospital of Jilin University, Changchun 130022, Jilin Province, China
  • Supported by:

    the Science and Technology Development Program of Jilin Province, No. 20180101118JC (to LR)

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摘要：

文章快速阅读：

文题释义：
槲皮素：是中药及天然植物中提取的黄酮类化合物，又称为栎精、槲皮黄素，广泛存在于植物的花、叶子和果实中。研究发现，槲皮素具有抗氧化、抗炎、抗凋亡和神经保护等作用，可以阻断缺血性脑损伤的多个病理坏节，显著改善神经损伤。
创伤性脑损伤：是外部直接机械损伤引起大脑中枢神经系统变性和神经元细胞坏死的疾病。
摘要
背景：创伤性脑损伤具有和缺血性脑损伤相类似的缺血缺氧等病理改变，研究发现槲皮素在创伤性脑损伤治疗中有显著效果。
目的：综述槲皮素在创伤性脑损伤治疗中的研究现状和展望。
方法：应用计算机检索万方、中国知网(CNKI)和PubMed生物医学数据库，检索时间为1900年至2018年12月，中文检索关键词为“槲皮素和脑损伤；槲皮素和创伤性脑损伤；槲皮素和氧化反应；槲皮素和神经细胞凋亡；槲皮素和炎症因子；创伤性脑损伤和氧化反应；创伤性脑损伤和神经细胞凋亡；创伤性脑损伤和炎症因子；槲皮素和生物安全性”，英文检索关键词为“Quercetin and Brain Injury; Quercetin and Traumatic Brain Injury; Quercetin and oxidation reaction; Quercetin and neurons apoptosis; Quercetin and inflammatory factor; Traumatic Brain Injury and oxidation reaction; Traumatic Brain Injury and apoptosis; Traumatic Brain Injury and inflammatory factor; Quercetin and biosafety”，纳入有关槲皮素在创伤性脑损伤中作用的相关论文报道和综述。
结果和结论：槲皮素可以通过调节氧化应激反应中的抗氧化酶实现自身对活性氧的清除，并促进线粒体自身的生物合成来改善线粒体的能量代谢，进一步保护神经元细胞内的线粒体。槲皮素还可通过抑制磷酸激酶C(PKC)的活性及转运，拮抗钠离子内流，从而抑制组胺、前列腺素等炎症递质的释放，缓解炎症。使用槲皮素治疗后可以通过激活PI3K/Akt通路并抑制ERK1/2信号通路从而减弱神经元细胞的自噬和凋亡，达到改善神经功能缺损和认知功能的作用。动物安全性评价实验提示，在合理剂量范围内可以认为槲皮素的安全性较高。槲皮素对创伤性脑损伤有显著治疗效果，与其具有清除氧自由基、保护线粒体、拮抗炎症反应和减少神经元细胞凋亡等有关。槲皮素在创伤性脑损伤治疗中的潜在分子机制和临床应用仍需不断研究。

关键词: 槲皮素, 创伤性脑损伤, 线粒体, 氧化应激, 活性氧簇, 炎症反应, 神经保护, 细胞凋亡

Abstract:

BACKGROUND: Traumatic brain injury has pathological changes such as ischemia and hypoxia, which are similar to ischemic brain damage. Quercetin has been shown to hold significant effect in the treatment of traumatic brain injury.
OBJECTIVE: To review the research status and prospects of quercetin in the treatment of traumatic brain injury.
METHODS: Databases of WanFang, CNKI and PubMed were searched for the articles published from 1900 to December 2018. The keywords were “quercetin and brain injury; quercetin and traumatic brain injury; quercetin and oxidation reaction; quercetin and neurons apoptosis; quercetin and inflammatory factor; traumatic brain injury and oxidation reaction; traumatic brain injury and apoptosis; traumatic brain injury and inflammatory factor; quercetin and biosafety” in Chinese and English, respectively. The reports and reviews on the role of quercetin in traumatic brain injury were included.
RESULTS AND CONCLUSION: Quercetin can regulate antioxidant enzymes in oxidative stress to eliminate reactive oxygen species, improve the energy metabolism of mitochondria by promoting the biosynthesis of mitochondria themselves, and further protect mitochondria in neurons. Quercetin can also inhibit the activity and transport of phosphokinase C, antagonize the influx of sodium ions, thus inhibiting the release of histamine, prostaglandins and other inflammatory mediators, and alleviate inflammation. After treatment with quercetin, the autophagy and apoptosis of neurons can be weakened by activating PI3K/Akt signaling pathway and inhibiting ERK1/2 signaling pathway, and the neurological deficit and cognitive function can be improved. In animal safety evaluation test, the safety of quercetin can be considered to be high in a reasonable dose range. Quercetin has a significant therapeutic effect on traumatic brain injury, which is related to its scavenging oxygen free radicals, protecting mitochondria, antagonizing inflammatory reaction and reducing neuronal apoptosis. The potential molecular mechanism and clinical application of quercetin in the treatment of traumatic brain injury still need to be studied in depth.

Key words:  quercetin, traumatic brain injury, mitochondria, oxidative stress, reactive oxygen species, inflammation reactions, neuroprotection, cell apoptosis

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