中国组织工程研究

中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (28): 4574-4579.doi: 10.3969/j.issn.2095-4344.0299

• 组织构建综述 tissue construction review • 上一篇    下一篇

巨噬细胞游走抑制因子基因多态性与疾病相关性的认识、靶点及意义

李  静1，2，彭  芸3，4，宝福凯2，3，4，5，6，柳爱华3，4，5，6，7   

  1. 1四川省遂宁市中医院，四川省遂宁市  629000；昆明医科大学，2病原生物学与免疫学系，3热带医学研究所，4云南省高校热带传染病重点实验室，7生物化学与分子生物学系，云南省昆明市  650500；5云南省公共卫生与疾病防控协同创新中心，云南省昆明市  650500；6云南省热带病示范型国际科技合作基地，云南省昆明市  650500
  • 通讯作者: 宝福凯，博士，教授，博士生导师。昆明医科大学病原生物学与免疫学系，云南省昆明市 650500；昆明医科大学热带医学研究所，云南省昆明市 650500；昆明医科大学云南省高校热带传染病重点实验室，云南省昆明市 650500；云南省公共卫生与疾病防控协同创新中心，云南省昆明市 650500；云南省热带病示范型国际科技合作基地，云南省昆明市 650500 并列通讯作者：柳爱华，硕士生导师，教授。昆明医科大学热带医学研究所，云南省昆明市 650500；昆明医科大学云南省高校热带传染病重点实验室，云南省昆明市 650500；云南省公共卫生与疾病防控协同创新中心，云南省昆明市 650500；云南省热带病示范型国际科技合作基地，云南省昆明市 650500；昆明医科大学生物化学与分子生物学系，云南省昆明市 650500
  • 作者简介:李静，女，1984年生，陕西省人，就职于四川省遂宁市中医院。 并列第一作者：彭芸，女，1992年生，安徽省人，昆明医科大学硕士，主要从事热带传染病的学习和研究。
  • 基金资助:

    国家自然科学基金资助项目(81371835，31560051，81560596)；云南省科技厅-昆明医科大学联合基金项目(云南省科技计划项目)( 2010CD221，2011FB244，2012FB011，2013FZ057，2014FA011，2014FB001)

Correlation between gene polymorphism of macrophage migration inhibitory factor and disease susceptibility: recognition, target and significance

Li Jing1, 2, Peng Yun3, 4, Bao Fu-kai2, 3, 4, 5, 6, Liu Ai-hua3, 4, 5, 6, 7   

  1. 1Suining Municipal Hospital of TCM, Suining 629000, Sichuan Province, China; 2Department of Microbiology and Immunology, 3Institute for Tropical Medicine, 4Yunnan Provincial Key Laboratory for Tropical Infectious Diseases, 7Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, Yunnan Province, China; 5Yunnan Provincial Collaborative Innovation Center for Public Health and Disease Prevention and Control, Kunming 650500, Yunnan Province, China; 6Yunnan Provincial Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming 650500, Yunnan Province, China
  • Contact: upervisor, Department of Microbiology and Immunology, Kunming Medical University, Kunming 650500, Yunnan Province, China Corresponding author: Liu Ai-hua, Master’s supervisor, Professor, Institute for Tropical Medicine of Kunming Medical University, Kunming 650500, Yunnan Province, China
  • About author:Li Jing, Suining Municipal Hospital of TCM, Suining 629000, Sichuan Province, China; Department of Microbiology and Immunology, Kunming Medical University, Kunming 650500, Yunnan Province, China Peng Yun, Master, Institute for Tropical Medicine of Kunming Medical University, Kunming 650500, Yunnan Province, China; Yunnan Provincial Key Laboratory for Tropical Infectious Diseases in Kunming Medical University, Kunming 650500, Yunnan Province, China; Li Jing and Peng Yun contributed equally to this work.
  • Supported by:

    the National Natural Science Foundation of China, No. 81371835, 31560051 and 81560596; the Project of Yunnan Provincial Science and Technology Department-Kunming Medical University (the Science and Technology Program of Yunnan Province), No. 2010CD221, 2011FB244, 2012FB011, 2013FZ057, 2014FA011 and 2014FB001

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摘要：

文章快速阅读：

文题释义：
巨噬细胞游走抑制因子：是一种重要的前炎性因子，主要由免疫系统中的T细胞产生，巨噬细胞游走抑制因子也可以由单核/巨噬细胞、垂体前叶细胞分泌，巨噬细胞游走抑制因子具有多种生物学功能，包括抑制巨噬细胞游走移动，促进巨噬细胞和T淋巴细胞在炎性反应局部浸润、聚集、增生、活化，增强其黏附、吞噬作用，还能促进多种细胞因子的生成等。
自身免疫性疾病：是指人体对自身抗原发生免疫反应而导致自身组织损害所引起的疾病，如类风湿性关节炎，系统性红斑狼疮等疾病。
摘要
背景：巨噬细胞游走抑制因子的表达水平在多种疾病中发生改变，其多态性与疾病的易感性、严重程度等相关。文章对巨噬细胞游走抑制因子的基本理化性质、巨噬细胞游走抑制因子基因多态性与疾病易感性的研究进展做一综述。
目的：分析巨噬细胞游走抑制因子在各种疾病中的作用机制。
方法：应用计算机检索PubMed，SinoMed，CNKI等数据库有关巨噬细胞游走抑制因子与疾病相关的文献，检索词为“MIF，disease，polymorphism；巨噬细胞游走抑制因子，多态性”，最终筛选出58篇。
结果与结论：无论是自身免疫性疾病、炎性疾病还是在癌症等各系统疾病中均有巨噬细胞游走抑制因子的参与，但巨噬细胞游走抑制因子在各系统疾病中发挥的作用并不相同，如巨噬细胞游走抑制因子既会促进脂肪细胞中肿瘤坏死因子α的分泌产生胰岛素抵抗，又可通过干扰胰岛素介导的内皮细胞一氧化氮释放，参与内皮细胞胰岛素抵抗的发生。巨噬细胞游走抑制因子抵抗糖皮质激素效应且恢复巨噬细胞因子表达和使T淋巴细胞活化，在调节炎症反应的调定点和方向中起着重要作用。因此，了解巨噬细胞游走抑制因子基因的多态与系统疾病存在的互作关系，有利于巨噬细胞游走抑制因子在各系统疾病的基础研究的开展，同时对于发现通过巨噬细胞游走抑制因子作为治疗靶点治疗各种疾病有重要的临床意义。

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程
ORCID: 0000-0002-5554-9872(柳爱华)

关键词: 巨噬细胞游走抑制因子, MIF, 多态性, 疾病, 易患性, 相关性, 自身免疫性, 炎性疾病, 癌症, 神经系统性疾病

Abstract:

BACKGROUND: Changes in the expression levels of macrophage migration inhibitory factor (MIF) occur in a variety of diseases, and the gene polymorphism of MIF is related to the disease susceptibility and severity. The basic physicochemical properties of MIF, and correlation of MIF gene polymorphism with disease susceptibility are summarized.
OBJECTIVE: To analyze the mechanisms of MIF in various diseases.
METHODS: Databases of PubMed, Sino Med and CNKI were searched by computer for the articles concerning MIF and diseases using the keywords of “MIF, disease, polymorphism” in English and Chinese, respectively. Finally 58 eligible articles were included.
RESULTS AND CONCLUSION: MIF is involved in various diseases such as autoimmune disease, inflammatory disease and cancer. However, MIF plays different roles in various systemic diseases, for example, MIF promotes the secretion of tumor necrosis factor α in adiposities inducing insulin resistance. It also interferes with insulin-mediated NO release from endothelial cells and participates in the development of insulin resistance in endothelial cells. MIF counteracts glucocorticoid effects, restores macrophage factor expression and activates T lymphocytes, which plays an important role in the regulation of inflammatory response. Therefore, to understand the interaction between MIF gene polymorphism and systemic diseases is conducive to the development of basic research on MIF in various systemic diseases. It is of great significance to find MIF as a therapeutic target for various diseases.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Macrophage Migration-Inhibitory Factors, Polymorphism, Single Nucleotide, Immune System Diseases, Neoplasms, Cardiovascular Diseases

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