中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (26): 4776-4780.doi: 10.3969/j.issn.1673-8225.2012.26.006

• 人工假体 artificial prosthesis • 上一篇    下一篇

人工关节磨屑的提取及表征

魏慧慧，刘洪涛，曹希传，贾玉梅   

  1. 中国矿业大学材料科学与工程学院，江苏省徐州市 221008
  • 收稿日期:2011-10-11 修回日期:2012-01-21 出版日期:2012-06-24 发布日期:2013-11-02
  • 作者简介:魏慧慧★，女，1986年生，河北省柏乡县人，汉族，在读硕士，主要从事生物纳米材料方面的研究。 weihui-8608@163.com
  • 基金资助:

    国家自然科学基金项目(51075387)，课题名称:人工关节纳米磨屑提取分析与生物学反应研究；国家自然科学基金项目(306709557)，课题名称：表面修饰介孔分子筛对小分子基因药物的运输和控制释放；江苏省自然科学基金项目(BK2008132)，课题名称：表面修饰纳米空洞材料基因药物运输。

Isolation and description of the artificial joint wear debris

Wei Hui-hui, Liu Hong-tao, Cao Xi-chuan, Jia Yu-mei   

  1. School of Materials Science and Engineering, China University of Mining and Technology, Xuzhou 221008, Jiangsu Province, China
  • Received:2011-10-11 Revised:2012-01-21 Online:2012-06-24 Published:2013-11-02
  • About author:Wei Hui-hui★, Studying for master’s degree, School of Materials Science and Engineering, China University of Mining and Technology, Xuzhou 221008, Jiangsu Province, China weihui-8608@163.com

PDF

436

被引次数

7

摘要：

背景：磨屑引起生物学反应从而导致人工关节的无菌性松动是假体失效的主要原因，因此获取人工关节磨屑研究其生物学反应对提高人工关节寿命有重要意义。
目的：获取纳米级人工关节磨损磨屑，进一步研究生物学反应。
方法：通过酸消化法和酶降解法获取人工关节磨屑，比较其分离效果，并获取不同尺寸的粒子，观察纳米粒子的形态。
结论与结论：①全髋关节模拟试验机运转循环次数对超高相对分子质量聚乙烯磨屑大小、形貌有一定的影响。②磨屑粒径分布范围很广，大到100 μm以上，小到小于1 μm。③从消化方法上来看，酶消化和酸消化法分离超高相对分子质量聚乙烯磨屑有效可行。

关键词: 磨屑, 人工关节, 超高相对分子质量聚乙烯, 分离, 表征

Abstract:

BACKGROUND: Aseptic loosening of artificial joints resulted by wear debris caused biological response is the main reason for prosthesis failure. Therefore, to obtain the artificial joints wear debris and to study the biological response is important for the improvement of artificial joint life.
OBJECTIVE: To obtain the nanoscale artificial joints wear debris, and to further study the biological response.
METHODS: The artificial joints wear debris was obtained by acid digestion and enzymatic degradation methods and the separation efficiency of these two methos was compared. Different sizes of particles were obtained and the morphology of nanoparticles was observed.
RESULTS AND CONCLUSION: ①The operation cycle times of total hip simulation testing machine have a certain impact on the size and morphology of ultrahigh molecular weight polyethylene wear debris. ②The distribution range of wear debris particle size was changed from 100 μm to 1 μm. It was feasible to isolate the ultrahigh molecular weight polyethylene wear debris by acid digestion and enzymatic degradation.

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