中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (25): 4654-4658.doi: 10.3969/j.issn.1673-8225.2012.25.019

• 材料力学及表面改性 material mechanics and surface modification • 上一篇    下一篇

ε-己内酯/D，L-丙交酯共聚物的非等温结晶动力学研究

杨立群，杨 丹，李建新，关艳敏，李 淼   

  1. 辽宁省计划生育科学研究院，辽宁省沈阳市 110031
  • 收稿日期:2011-12-11 修回日期:2012-01-12 出版日期:2012-06-17 发布日期:2013-11-04
  • 通讯作者: 杨丹，研究员，辽宁省计划生育科学研究院，辽宁省沈阳市 110031 yangdan0108@ 126.com
  • 作者简介:杨立群☆，男，1982年生，辽宁省葫芦岛市人，汉族，四川大学在读博士，助理研究员，主要从事生物医药高分子材料研究。 yangliqun21@ 163.com
  • 基金资助:

    辽宁省自然科学基金资助项目(20092017)

Non-isothermal crystallization kinetics of degradable copolymer based on epsilon-caprolactone and D, L-lactide

Yang Li-qun, Yang Dan, Li Jian-xin, Guan Yan-min, Li Miao   

  1. Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China
  • Received:2011-12-11 Revised:2012-01-12 Online:2012-06-17 Published:2013-11-04
  • Contact: Yang Dan, Research fellow, Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China yangdan0108@ 126.com
  • About author:Yang Li-Qun☆, Studying for doctorate, Research assistant, Liaoning Research Institute of Family Planning, Shenyang 10031, Liaoning Province, China yangliqun21@ 163.com

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摘要：

背景：ε-己内酯/D，L-丙交酯共聚物因具有良好的力学性能、降解性能以及生物相容性而受到广泛研究，但对其非等温结晶动力学研究相对较少。
目的：了解ε-己内酯/D，L-丙交酯共聚物的非等温结晶动力学性能。
方法：以实验室自制的ε-己内酯∶D，L-丙交酯共聚物90∶10为观察对象，采用示差扫描量热仪对其进行非等温测试，观察其结晶行为。
结果与结论：随着降温速率R的增加，PCDLA的结晶温度向低温方向移动，且Avrami指数均>3，以均相成核的三维球晶方式生长；Jeziorny法和莫志深法研究结果基本一致。

关键词: 非等温结晶动力学, ε-己内酯, D, L-丙交酯, 共聚物, 生物降解材料, 生物材料

Abstract:

BACKGROUND: Copolymers of ε-caprolactone and D, L-lactide (PCDLA) has been studied intensely for their good mechanical properties, biodegradability and biocompatibility. However, the study on non-isothermal crystallization kinetics of PCDLA has attracted less attention.
OBJECTIVE: To investigate the non-isothermal crystallization kinetics of PCDLA.
METHODS: PCDLA with a CL/DLLA molar ratio of 90:10 was prepared by ring-opening polymerization and differential scanning calorimetry was employed to study the non-isothermal crystallization kinetics of PCDLA. The kinetics parameters were analyzed by Avrami, Jeziorny and Mo methods.
RESULTS AND CONCLUSION: The crystallization peak temperatures of PCDLA decreased with increasing cooling rate. In the process of non-isothermal crystallization, the value of Avrami index was greater than 3 for PCDLA, which demonstrates a three-dimensional spherulitic growth on homogeneous nuclei. The Jeziorny method of the corrected Avrami theories and Mo method can describe non-isothermal crystallization kinetics of PCDLA very well.

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