中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (23): 4349-4353.doi: 10.3969/j.issn.1673-8225.2012.23.033032

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞治疗1型糖尿病的研究与应用进展

胡美君，潘兴华，庞荣清，蔡学敏   

  1. 解放军成都军区昆明总医院干细胞与组织器官工程研究中心，云南省干细胞工程实验室，昆明医学院昆明总医院临床学院，云南省昆明市 650032
  • 收稿日期:2011-10-30 修回日期:2011-11-17 出版日期:2012-06-03 发布日期:2013-11-06
  • 作者简介:胡美君★，女， 1985年生，云南省大理州洱源县人，布依族，2009年昆明医学院毕业，硕士，主要从事干细胞治疗研究。 119589025@qq.com

Research progress of stem cell therapy for type 1 diabetes mellitus

Hu Mei-jun, Pan Xing-hua, Pang Rong-qing, Cai Xue-min   

  1. Research Center of Stem Cells and Tissue and Organ Engineering, Kunming General Hospital in Chengdu Military Area Command of Chinese PLA, Clinical College, Kunming General Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China
  • Received:2011-10-30 Revised:2011-11-17 Online:2012-06-03 Published:2013-11-06
  • About author:Hu Mei-jun★, Master, Research Center of Stem Cells and Tissue and Organ Engineering, Kunming General Hospital in Chengdu Military Area Command of Chinese PLA, Clinical College, Kunming General Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China 119589025@qq.com

PDF

638

被引次数

10

摘要：

背景：通过胰腺或胰岛移植等重建胰岛素分泌系统是治疗1型糖尿病的有效方法，但材料来源受限，移植后免疫排斥反应易导致治疗失败。
目的：简要总结了胚胎干细胞、成体干细胞及诱导性多能干细胞等治疗1型糖尿病的研究进展。
方法：应用计算机检索CNKI和PubMed数据库中2008-01/2011-12关于干细胞治疗1型糖尿病的文章，在标题和摘要中以“胚胎干细胞；成体干细胞；诱导性多能干细胞；1型糖尿病”或“Embryonic stem cells，somatic stem cells，induced pluripotent stem cells，type 1 diabetes”为检索词进行检索。选择文章内容与干细胞治疗1型糖尿病相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到128篇文献，根据纳入标准选择33篇文章进行综述。
结果与结论：目前，不同来源的干细胞在体内外均能被诱导为产生胰岛素的细胞，并且这种诱导细胞用于1型糖尿病动物模型治疗，具有一定治疗效果，甚至能使受体血糖恢复正常水平，但干细胞是否参与胰岛细胞再生或修复尚存在争议。

关键词: 胚胎干细胞, 成体干细胞, 1型糖尿病, 干细胞, 诱导多功能干细胞

Abstract:

BACKGROUND: The possible effective way for the treatment of type 1 diabetes mellitus is to rebuild the secreting system of insulin through pancreatic or pancreatic islet transplantation. However, limited donors and rejection after transplantation often lead to failed treatment.
OBJECTIVE: To summarize the study progress in embryonic stem cells, somatic stem cells and induced pluripotent stem cells for the treatment of type 1 diabetes mellitus.
METHODS: Articles addressing stem cells for the treatment of type 1 diabetes mellitus were retrieved online in CNKI database and PubMed database from January 2008 to December 2011 with the key words of “embryonic stem cells, somatic stem cells, induced pluripotent stem cells, type 1 diabetes mellitus” in Chinese and English in the title and abstract. The articles related to stem cells for the treatment of type 1 diabetes were included. For the articles in the same field, those published recently or in the authorize journals were preferred. A total of 128 literatures were obtained, and 33 documents of them were involved for review according to the inclusion criteria.
RESULTS AND CONCLUSION: Recently, different sources of stem cells could be induced into insulin-producing cells in vivo or in vitro, and the induced cells were used in the treatment of animal model with type 1 diabetes. It showed certaub therapeutic efficacy and even made recipient’s blood sugar level returned to normal. But controversy exists regarding whether stem cells took part in islet cell regeneration or repair.

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