中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (23): 4354-4358.doi: 10.3969/j.issn.1673-8225.2012.23.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞移植治疗脊髓损伤的应用技术

王 格1，武栋成2   

  1. 1武汉大学，湖北省武汉市 430071；
    2武汉大学生物化学系，武汉红桥脑科医院，湖北省武汉市 430071
  • 收稿日期:2011-11-08 修回日期:2011-11-28 出版日期:2012-06-03 发布日期:2013-11-06
  • 通讯作者: 武栋成，博士生导师，武汉大学生物化学教研室，武汉红桥脑科医院，湖北省武汉市 430071 bcdcwu@hotmail.com
  • 作者简介:王格，女，1989年生，湖南省衡阳县人，汉族，武汉大学在读，主要从事干细胞研究。 gege3192@126.com
  • 基金资助:

    国家自然科学基金项目(面上项目，30670813)

Application of bone marrow mesenchymal stem cells transplantation for the treatment of spinal cord injury

Wang Ge1, Wu Dong-cheng2   

  1. 1Wuhan University, Wuhan 430071, Hubei Province, China;
    2Department of Biochemistry, Wuhan University, Wuhan Hongqiao Brain Hospital, Wuhan 430071, Hubei Province, China
  • Received:2011-11-08 Revised:2011-11-28 Online:2012-06-03 Published:2013-11-06
  • Contact: Wu Dong-cheng, Doctoral supervisor, Department of Biochemistry, Wuhan University, Wuhan Hongqiao Brain Hospital, Wuhan 430071, Hubei Province, China bcdcwu@hotmail.com
  • About author:Wang Ge, Wuhan University, Wuhan 430071, Hubei Province, China gege3192@126.com

PDF

436

被引次数

9

摘要：

背景：目前临床上对脊髓损伤患者脊神经的萎缩与坏死缺乏有效的修复方法。研究发现干细胞移植治疗脊髓损伤具有广阔的应用前景。
目的：综述骨髓间充质干细胞移植治疗脊髓损伤的研究进展。
方法：由第一作者检索2001/2011 PubMed 数据库(http://www.ncbi.nlm.nih.gov/PubMed)及万方数据库(http://g. wanfangdata.com.cn/)有关骨髓间充质干细胞、脊髓损伤、细胞移植等方面的文章，英文检索词为 “bone marrow mesenchymal stem cells，spinal cord injury，cell transplantation”，排除重复性研究，共保留其中的32篇文献进行归纳总结。
结果与结论：骨髓间充质干细胞移植治疗脊髓损伤的研究在脊髓损伤模型制作、移植时间、移植方式、移植浓度、联合移植等多方面取得了成就，临床实验在国内外也已有所开展。但移植机制仍不十分明确，临床移植治疗的安全性和疗效需进一步研究。

关键词: 脊髓损伤, 骨髓间充质干细胞, 细胞移植, 研究, 治疗, 干细胞

Abstract:

BACKGROUND: At present, there lacks effective repair approach for atrophy and necrosis of spinal nerve of spinal cord injury patients in the clinic. Bone marrow mesenchymal stem cells transplantation for the treatment of spinal cord injury has wide application prospects.
OBJECTIVE: To summarize the progress of bone marrow mesenchymal stem cells transplantation for the treatment of spinal cord injury.
METHODS: The first author searched PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://g.wanfangdata.com.cn/) for literatures concerning bone marrow mesenchymal stem cells, spinal cord injury and cell transplantation from 2001 to 2011. Key words were “bone marrow mesenchymal cells, spinal cord injury, cell transplantation” in English. Duplicate articles were excluded. Finally, 32 articles were selected to summarize.
RESULTS AND CONCLUSION: The research of bone marrow mesenchymal stem cells transplantation for treatment of spinal cord injury has made achievements in the spinal cord injury model establishment, transplantation time and approach, concentration and combined transplantation. Although clinical trials have been carried out at home and abroad, the mechanism was not very clear yet. The safety and efficacy of clinical treatment need further investigation.

中图分类号: