中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (14): 2641-2644.doi: 10.3969/j.issn.1673-8225.2012.14.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

维生素D及其受体与毛发的关系★

卓  纳1，辛  燕2，郭果香1   

  1. 1内蒙古医学院，内蒙古自治区呼和浩特市010059；2内蒙古医学院第三附属医院-包钢医院皮肤科，内蒙古自治区包头市014010
  • 收稿日期:2012-01-09 修回日期:2012-02-06 出版日期:2012-04-01 发布日期:2012-04-01
  • 通讯作者: 辛燕，硕士，主任医师，内蒙古医学院第三附属医院包钢医院皮肤科，内蒙古自治区包头市014010 xinyan69@yahoo.com.cn
  • 作者简介:卓纳★，女，1986年生，内蒙古呼和浩特市人，蒙古族，内蒙古医学院在读硕士，主要从事毛发学的研究。994416880@qq.com

Relationship between vitamin D, vitamin D receptor and hair

Zhuo Na1, Xin Yan2, Guo Guo-xiang1   

  1. 1Inner Mongolian Medical College, Hohhot  010059，Inner Mongolian Autonomous Region, China; 2Department of Dermatology, Third Affiliated Hospital (Baogang Hospital) of Inner Mongolian Medical College, Baotou  014010，Inner Mongolian Autonomous Region, China
  • Received:2012-01-09 Revised:2012-02-06 Online:2012-04-01 Published:2012-04-01
  • Contact: Xin Yan, Master, Chief physician, Department of Dermatology, Third Affiliated Hospital (Baogang Hospital) of Inner Mongolian Medical College, Baotou 014010，Inner Mongolian Autonomous Region, China xinyan69@yahoo.com.cn
  • About author:Zhuo Na★, Studying for master’s degree, Inner Mongolian Medical College, Hohhot 010059，Inner Mongolian Autonomous Region, China

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摘要：

背景：越来越多的研究发现，维生素D及其受体与毛发有一定关系。
目的：全面阐述维生素D及其受体与毛囊干细胞、毛发生长周期、信号转导以及脱发性疾病等的关系。
方法：应用计算机以“维生素D、维生素D受体、毛发、脱发、基因多态性”或“vitamin D，vitamin D receptor，hair，alopecia，gene polymorphism”为检索词检索PubMed和CNKI数据库1990/2011-11发表的关于维生素D及其受体与毛发关系的文章，同一领域选择近期发表或发表在权威杂志上的文章。
结果与结论：初检得到152篇文献，根据纳入排除标准选择30篇文章进行综述。目前研究显示，维生素D及其受体在毛发中扮演重要角色，其异常可导致脱发等疾病的产生，为预防和治疗脱发性疾病提供新的可能，并有望在未来广泛应用。
关键词：维生素D；维生素D受体；毛发；脱发；基因多态性；毛囊干细胞
doi:10.3969/j.issn.1673-8225.2012.14.035

关键词: 维生素D, 维生素D受体, 毛发, 脱发, 基因多态性, 毛囊干细胞

Abstract:

BACKGROUND: Increasing evidence has demonstrated that vitamin D and its receptor correlate with hair.
OBJECTIVE: To fully discuss the relationship between vitamin D, vitamin D receptor and hair follicle stem cells, hair cycle, signal transduction and alopecia.
METHODS: A computer online retrieval was performed in PubMed and CNKI database to search papers addressing the relationship between vitamin D, vitamin D receptor and hair published between November 1990 and November 2011 with the key words “ vitamin D, vitamin D receptor, hair, alopecia, gene polymorphism” in Chinese or English. Papers published recently or in the authoritative journals were selected.
RESULTS AND CONCLUSION: A total of 152 papers were initially retrieved. According to inclusion and exclusion criteria, 30 papers were selected. The current studies have shown that vitamin D and its receptor play an important role in hair and the disorder of vitamin D would lead to alopecia. Regulation of vitamin D and its receptor may be successful in preventing and treating hair disorders and is promising in future use.
 

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