中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (8): 1491-1495.doi: 10.3969/j.issn.1673-8225.2012.08.036

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同材料构建组织工程软骨及支架的应用★

张  新   

  1. 扬州大学体育学院，江苏省扬州市   225009
  • 收稿日期:2011-11-08 修回日期:2011-12-18 出版日期:2012-02-19 发布日期:2012-02-19
  • 作者简介:张新★，男，1966年生，江苏省连云港市人，汉族，1989年扬州师范学院毕业，硕士，副教授，主要从事体育心理学和体育保健学方面的研究。xzhang@yzu.cn

Applications of tissue-engineered cartilage and scaffold constructed using different materials

Zhang Xin   

  1. College of Physical Education, Yangzhou University, Yangzhou  225009, Jiangsu Province, China
  • Received:2011-11-08 Revised:2011-12-18 Online:2012-02-19 Published:2012-02-19
  • About author:Zhang Xin★, Master, Associate professor, College of Physical Education, Yangzhou University, Yangzhou 225009, Jiangsu Province, China xzhang@yzu.cn

PDF

362

摘要：

背景：组织工程技术的发展为软骨的再生和修复提供了新的途径，根据软骨自身的结构和特点，作为人工软骨的替代材料和支架材料应具有良好的生物力学性能。
目的：总结运动性关节软骨损伤修复材料及其支架材料的应用进展及其生物替代材料的生物力学特征，评价目前组织工程软骨材料应用的性能及发展前景。
方法：以“组织工程；软骨组织；支架材料；生物相容性”为关键词，应用计算机检索维普数据库和PubMed数据库中1990-01/2011-04关于组织工程软骨应用研究的文章，纳入与有关生物材料与组织工程软骨相关的文章；排除重复研究或Meta分析类文章。以24篇文献为主重点进行了讨论组织工程软骨材料的种类、性能及其应用效果和前景。
结果与结论：目前关节软骨修复领域以自体软骨移植效果为最佳，骨髓基质干细胞在离体试验及动物实验中研究较多，在临床应用中较少，尚在探索阶段。支架材料的应用比较繁复，天然材料、人工合成材料以及复合材料都存在一定的不足，虽然复合材料成为研究的热点，但是某些性能并不能很好地符合支架要求，并且在机体内这些材料所带来的长期影响还不能预见，这就迫切需要新材料的出现，来更好地满足组织软骨织支架的要求，达到修复和重建的目的。
关键词：软骨；组织工程；软骨组织；种子细胞；支架材料
doi:10.3969/j.issn.1673-8225.2012.08.036

关键词: 软骨, 组织工程, 软骨组织, 种子细胞, 支架材料

Abstract:

BACKGROUND: The development of tissue engineering technology provides a new way for cartilage regeneration and repair; according to the structure and characteristics of cartilage, the substitute materials and scaffold materials, as artificial cartilage, should have good biomechanical properties.
OBJECTIVE: To summarize the application progress of repair materials and scaffold materials for exercise-induced articular cartilage injury; to summarize the biomechanical properties of biological substitute materials; to evaluate the performance and prospects of the current application of tissue-engineered cartilage materials.
METHODS: A computer-based online search of VIP Database and PubMed database was performed for the articles related to the application of tissue-engineered cartilage published from January 1990 to August 2011, with the key words of “tissue engineering”, “cartilage tissue”, “scaffold material” and “biological compatibility”. Articles related to the biomaterials and tissue-engineered cartilages were included; repetitive studies and Meta analysis were excluded. The types, performance, application effects and prospects of tissue-engineered cartilage materials were mainly discussed based on 24 documents.
RESULTS AND CONCLUSION: In the current field of cartilage repair, autologous cartilage transplantation has the best repairing effects; bone marrow stromal cells are well studied in animal experiments and in vitro tests, while their clinical applications are less reported and still in the exploratory stage. The applications of scaffold are complex; natural materials, synthetic materials and composite materials all have some deficiencies. Although the composite materials has become a hot research area, but its performance does not meet the requirement of scaffolds; and the long-term impacts caused by these materials on the body can not be seen. Therefore, there is an urgent need for new materials which can better meet the requirements of tissue-engineered cartilage scaffolds to achieve the purpose of repair and reconstruction.

中图分类号: