中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (8): 1387-1390.doi: 10.3969/j.issn.1673-8225.2012.08.013

• 组织工程血管材料 tissue-engineered vascular materials • 上一篇    下一篇

大节段生物活性陶瓷多孔支架肌内血管化：3年期3D-数字减影血管造影观察*★

任  翔，黄  鹏，姚一民，冯怀志，张文华，翁  杰，李  硕，张  聪   

  1. 解放军第四五二医院骨科，四川省成都市  610021
  • 收稿日期:2011-08-29 修回日期:2011-11-07 出版日期:2012-02-19 发布日期:2012-02-19
  • 通讯作者: 张聪，博士，主任医师，解放军第四五二医院，四川省成都市 610021 Cong60@ Hotmail.com
  • 作者简介:任翔★，男，1977年生，河南省沁阳市人，汉族，2007年四川大学华西临床医学院毕业，硕士，主治医师，主要从事人工骨材料研究。54374617@ qq.com
  • 基金资助:

    全军“十一五”科技攻关课题项目(06G049)。

Three-dimensional digital subtraction angiography observation of vascularization of large-segment bioactive ceramic scaffolds implanted into skeletal muscle within 3 years

Ren Xiang, Huang Peng, Yao Yi-min, Feng Huai-zhi, Zhang Wen-hua, Weng Jie, Li Shuo, Zhang Cong   

  1. Department of Orthopaedics, the 452 Hospital of Chinese PLA, Chengdu  610021, Sichuan Province, China
  • Received:2011-08-29 Revised:2011-11-07 Online:2012-02-19 Published:2012-02-19
  • Contact: Zhang Cong, Doctor, Chief physician, Department of Orthopaedics, the 452 Hospital of Chinese PLA, Chengdu 610021, Sichuan Province, China Cong60@ Hotmail.com
  • About author:Ren Xiang★, Master, Attending physician, Department of Orthopaedics, the 452 Hospital of Chinese PLA, Chengdu 610021, Sichuan Province, China 54374617@qq.com
  • Supported by:

    Project of Military “Eleventh Five-Year” Scientific and Technological Foundation, No. 06G049*

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摘要：

背景：人工骨材料生物体内的活化，与自体骨生物键合，完成自体骨组织爬行替代，核心是材料的血管化。如何判断血管化发生？
目的：观察大节段生物活性陶瓷多孔支架骨骼肌内植入3年后血管化情况。
方法：雄性中国自养犬10只，于骨骼肌内植入直径1.5 cm、长4.0~4.5 cm羟基磷灰石-聚乳酸多孔支架，饲养36个月后行3D数字减影血管造影检查。
结果与结论：所有动物均顺利完成材料植入及数字减影血管造影成像，且所得结果相似：营养血管由股动脉、股深动脉发出并指向羟基磷灰石-聚乳酸支架，分支后进入材料。结果表明，3D数字减影血管造影技术是用于监测人工骨材料体内血管化的有效手段，羟基磷灰石-聚乳酸支架骨骼肌内植入3年后能够形成完整的动静脉血循环系统。

关键词: 生物活性陶瓷, 血管化数字减影血管造影技术, 羟基磷灰石, 聚乳酸, 支架

Abstract:

BACKGROUND: The core of the artificial bone material activating, biological bonding with autologous bone and completion of autologous bone creeping substitution in vivo is vascularization. The occurrence of vascularization is still unclear.
OBJECTIVE: To observe the vascularization of the large segment of bioactive ceramic scaffold implanted into the skeletal muscle for 3 years.
METHODS: Ten male dogs were selected for implanting porous hydroxyapatite-polylactic acid scaffold (diameter of 1.5 cm, length of 4-4.5 cm) in skeletal muscles. Thirty-six months later, three-dimensional digital subtraction angiography (3D-DSA) was performed.
RESULTS AND CONCLUSION: All the dogs underwent operation and 3D-DSA successful and the results were similar. 3D-DSA showed: nutrient arteries derived from the femoral artery and deep femoral artery and pointed to the hydroxyapatite-polylactic acid scaffold, the branches inserted into the hydroxyapatite-polylactic acid scaffold. 3D-DSA is an effective means of observation of vascularization of artificial bone in vivo. The integral arterial and venous blood circulatory system can be established in hydroxyapatite-polylactic acid scaffold implanted in skeletal muscle for 3 years.

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