中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (7): 1237-1240.doi: 10.3969/j.issn.1673-8225.2012.07.023

• 组织构建实验造模 experimental modeling in tissue construction • 上一篇    下一篇

重复长时间正加速度暴露动脉粥样硬化家兔模型血清超敏C-反应蛋白的变化☆

罗慧兰1，陈勇胜2   

  1. 1解放军空军总医院，北京市  100142；2解放军空军航空医学研究所，北京市  100142
  • 收稿日期:2011-05-23 修回日期:2011-05-29 出版日期:2012-02-12 发布日期:2012-02-12
  • 通讯作者: 1解放军空军总医院，北京市 100142；2解放军空军航空医学研究所，北京市 100142
  • 作者简介:罗慧兰★，1950年生，博士，主任医师，硕士导师，主要从事心血管功能及康复方面的研究。

Serum level of high-sensitivity C-reactive protein in a rabbit model of atherosclerosis following repeated long-term exposure to positive acceleration☆

Luo Hui-lan1, Chen Yong-sheng2   

  1. 1The General Hospital of the Air Force of Chinese PLA, Beijing  100142, China; 2Institute of Aviation Medicine of the Air Force of Chinese PLA, Beijing  100142, China
  • Received:2011-05-23 Revised:2011-05-29 Online:2012-02-12 Published:2012-02-12
  • Contact: 1The General Hospital of the Air Force of Chinese PLA, Beijing 100142, China; 2Institute of Aviation Medicine of the Air Force of Chinese PLA, Beijing 100142, China
  • About author:Luo Hui-lan☆, Doctor, Chief physician, Master’s supervisor, the General Hospital of the Air Force of Chinese PLA, Beijing 100142, China Luohuilan50@sina.com

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摘要：

背景：血清超敏C-反应蛋白的水平能够预测心血管损伤。
目的：探讨重复正加速度暴露时动脉粥样硬化模型家兔血清超敏C-反应蛋白的变化与心血管损伤的风险预测。
方法：将24只新西兰纯种兔随机等分为正加速度组和对照组。正加速度组兔先在+4 g水平(持续20 s，增长率为1 g/s)下暴露，旋转间隔时间为5 min，连续旋转3次，每周   3 d。每周增加0.5 g，至第4周时增加至    +6 g，持续暴露40 s。
结果与结论：正加速度暴露对动脉粥样硬化家兔静脉血超敏C-反应蛋白水平影响的差异有显著性意义(P < 0.01)；但暴露时间对兔超敏C-反应蛋白水平不产生影响        (P > 0.05)；正加速度暴露与持续时间之间的交互效应对超敏C-反应蛋白表达量的影响差异也无显著性意义(P > 0.05)。兔主动脉内膜下及中膜浅层增生的泡沫细胞量随正加速度暴露的延长而增加，反复及长时间正加速度暴露有可能导致兔血清超敏C-反应蛋白长期处于高水平状态。
关键词：正加速度；兔；超敏C-反应蛋白；主动脉；血管内膜；危险性评估
doi:10.3969/j.issn.1673-8225.2012.07.023
中图分类号: R318  文献标识码: B  

关键词: 正加速度, 兔, 超敏C-反应蛋白, 主动脉, 血管内膜, 危险性评估

Abstract:

BACKGROUND: Serum levels of high-sensitivity C-reactive protein (hs-CRP) can be used to predict cardiovascular injury.
OBJECTIVE: To investigate the serum levels of hs-CRP in a rabbit model of atherosclerosis following repeated long-term exposure to positive acceleration and to predict the risk of cardiovascular injury.
METHODS: Twenty-four New Zealand purebred rabbits were randomly divided into a positive acceleration group and a control group. Rabbits in the positive acceleration group were exposed to +4 g rotation for 20 seconds with an acceleration of 1 g/s. The rotation interval was 5 minutes and totally three rotations were daily performed for 3 days per week. 0.5 g rotation was added every week, and by week 4, +6 g rotation was added, and the exposure lasted for 40 seconds.
RESULTS AND CONCLUSION: Exposure to positive acceleration yielded significant effects on serum level of hs-CRP in rabbits with atherosclerosis compared with before exposure (P < 0.01), but exposure time did not produce effects on serum level of hs-CRP (P > 0.05). The interaction between exposure to positive acceleration and exposure time also did not produce significant effects on serum level of hs-CRP (P > 0.05). Hyperplastic foam cells in the aortic tunica intima and the superficial layer of media increased with the prolongation of exposure to positive acceleration. Repeated long-term exposure to positive acceleration may lead to a long-term high serum level of hs-CRP in rabbits.

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