中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (3): 405-408.doi: 10.3969/j.issn.1673-8225.2012.03.005

• 骨髓干细胞 bone marrow stem cells • 上一篇    下一篇

纳米载银磷酸锆抗菌聚氨酯的抗菌性能****★

邹兆伟，史福军，黄宗海，贺  艳，李  强，陈  飞，崔春晖   

  1. 南方医科大学附属珠江医院普外科，广东省广州市  510282 
  • 收稿日期:2011-11-23 修回日期:2011-12-09 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 黄宗海，教授，博士生导师，南方医科大学珠江医院普外科，广东省广州市 510282 drhuangzh@ yahoo.com.cn
  • 作者简介:邹兆伟★，男，1985年生，江西省瑞金市人，汉族，南方医科大学在读硕士，主要从事人工肛门括约肌生物材料的研究。 360094442@ qq.com
  • 基金资助:

    2009年海珠区科技计划项目(2009-Y-017)，课题名称：智能型原位人工肛门的研制；2009年广州市科技计划项目(2009Z1-E251)，课题名称：智能型原位人工肛门的研制；2009年广东省科技计划项目(2009A030200014)，课题名称：智能型纳米复合材料原位人工肛门的研制；2010年广东省产学研结合项目(2010B090400423)，课题名称：抗菌型有机硅橡胶人工肛门封堵器的研制与开发。

Antibacterial performance of nano-silver-zirconium phosphate antibacterial polyurethane

Zou Zhao-wei, Shi Fu-jun, Huang Zong-hai, He Yan, Li Qiang, Chen Fei, Cui Chun-hui   

  1. Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou  510282, Guangdong Province, China
     
  • Received:2011-11-23 Revised:2011-12-09 Online:2012-01-15 Published:2012-01-15
  • Contact: Huang Zong-hai, Professor, Doctoral supervisor, Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China drhuangzh@ yahoo.com.cn
  • About author:Zou Zhao-wei★, Studying for master’s degree, Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China 360094442@qq.com
  • Supported by:

    the Science and Technology Project of Haizhu District in 2009, No. 2009-Y-017*; the Science and Technology Project of Guangzhou in 2009, No. 2009Z1-E251*; the Science and Technology Project of Guangdong Province in 2009, No. 2009A030200014*; the Produce Study Grinds Unifies Project of Guangdong Province in 2010, No. 2010B090400423*

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摘要：

背景：聚氨酯材料具有优异的物理和化学性能，良好的生物相容性和抗凝血性能，且易加工成形，但聚氨酯制造的人工器官容易受到细菌等微生物的入侵。
目的：观察纳米载银无机抗菌剂对聚氨酯抗菌性能的影响。
方法：将纳米载银无机抗菌剂RHA-2，按0%(空白对照组)，0.5%，1%，1.5%，2%，2.5%，5%比例添加到聚氨酯中。采用薄膜密着法检测抗菌聚氨酯对金黄色葡萄球菌、大肠杆菌的抑菌作用，并分析比较抗菌剂添加比例与聚氨酯抗菌性能的相关性。
结果与结论：添加纳米载银无机抗菌剂的聚氨酯对金黄色葡萄球菌、大肠杆菌具有良好的抑菌作用。抗菌剂添加比例0.5%~5%组对金黄色葡萄球菌的抑菌率分别为80.23%，91.32%，95.23%，99.19%，99.87%，99.93%，对大肠杆菌的抑菌率分别为76.70%，86.96%，92.92%，95.43%，99.34%，99.87%，显示抗菌性能随抗菌剂添加比例的上升而明显提高。表明纳米载银无机抗菌剂的添加赋予了聚氨酯优异的抗菌性能，且从抗菌角度出发，推荐纳米载银无机抗菌剂在聚氨酯中的添加比例不应低于1.5%。

关键词: 纳米载银无机抗菌剂, 聚氨酯, 抗菌性能, 金黄色葡萄球菌, 大肠杆菌

Abstract:

BACKGROUND: Polyurethane material has excellent physical and chemical performances, good biocompatibility and anti-clotting properties, and is easy to shape. However, artificial organs manufactured using the polyurethane are vulnerable to the invasion of bacteria and other microorganisms.
OBJECTIVE: To explore the effects of nano-silver base inorganic antimicrobial agent on the antibacterial performance of polyurethane.
METHODS: The nano-silver base inorganic antimicrobial agent RHA-2 was added to polyurethane by the mass fractions of 0% (blank control), 0.5%, 1%, 1.5%, 2%, 2.5% and 5%, respectively. Antimicrobial properties of the polyurethane materials against Staphylococcus aureus and Escherichia coli were assayed using the pellicle sticking method.
RESULTS AND CONCLUSION: The polyurethane added with nano-silver base inorganic antimicrobial agents had a good antibacterial effect on Staphylococcus aureus and Escherichia coli. The inhibitory rate against Staphylococcus aureus in the groups containing 0.5%-5% antimicrobial agents were 80.23%, 91.32%, 95.23%, 99.19%, 99.87% and 99.93%, respectively; the inhibitory rate against Escherichia coli in the corresponding groups were 76.70%, 86.96%, 92.92%, 95.43%, 99.34% and 99.87%, respectively. The antimicrobial properties of polyurethane increased significantly with the increasing proportions of the antibacterial agents. These results indicate that nano-silver base inorganic antimicrobial agents can endow the polyurethanes an excellent antibacterial property. From the antimicrobial perspective, the recommended adding proportion of the nano-silver base inorganic antimicrobial agents in the polyurethane is no less than 1.5%.

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