中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (1): 1-10.doi: 10.3969/j.issn.1673-8225.2012.01.001

• 骨髓干细胞 bone marrow stem cells •    下一篇

间充质干细胞及其临床应用中的几个问题☆

郭子宽   

  1. 军事医学科学院放射与辐射医学研究所实验血液学研究室，北京市  100850
  • 收稿日期:2011-12-01 修回日期:2011-12-28 出版日期:2012-01-01 发布日期:2012-01-01
  • 作者简介:郭子宽☆，男，1967年生，河南省濮阳市人，汉族，北京医科大学毕业，博士，研究员，硕士研究生导师，主要从事干细胞和再生医学研究。zikuanguo@yahoo.com.cn

Some problematic issues about mesenchymal stem cells and their clinical application

Guo Zi-kuan   

  1. Hematology, Beijing Institute of Radiation Medicine, Beijing 100850, China
  • Received:2011-12-01 Revised:2011-12-28 Online:2012-01-01 Published:2012-01-01
  • About author:Guo Zi-kuan☆, Doctor, Researcher, Master’s supervisor, Department of Experimental

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摘要：

在血液病的治疗方面，骨髓造血干细胞的作用早已得到公识。目前，在许多国家间充质干细胞已经被批准进入多个临床试验，用于治疗移植物抗宿主病、克罗恩氏病、肝脏纤维化和骨关节损伤等多种疾病。然而，有关体内间充质干细胞的本质、体外培养后间充质干细胞的特性变化、细胞移植后在体内的分布、间充质干细胞治疗的作用机制及其临床应用的安全性等诸多根本性的问题，必须在间充质干细胞被广泛应用之前得以明确。这里尚有多少个不确定的环节？尚有多少个需要认识的关键性问题？文章结合以上问题，对近几年间充质干细胞的研究进展进行了综述和分析。

关键词: 间充质干细胞, 移植, 干细胞治疗, 临床试验

Abstract:

Till now, mesenchymal stem cells (MSCs) have been officially approved in a series of clinical trials to treat the patients with graft-versus-host disease, Crhon’s disease, liver fibrosis and osteoarticular injuries. However, before their wide use in clinical settings, the basic problematic issues about MSCs should be clarified. These key points, which will be here reviewed based on the recent advances on MSCs during the past several years, include the essences of MSCs inherently existing in vivo, the changes of their biological features after in vitro expansion, in vivo distribution after transplantation, the underlying mechanisms of MSCs therapy and its safety in clinical application.

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