中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (53): 10027-10030.doi: 10.3969/j.issn.1673-8225.2011.53.036

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

小肠移植后的感染及排斥反应

陈远崇   

  1. 张家口市第五医院普通外科，河北省张家口市075000
  • 收稿日期:2011-10-20 修回日期:2011-11-30 出版日期:2011-12-31 发布日期:2011-12-31
  • 作者简介:陈远崇，男，1965年生，汉族，河北省张家口市人，副主任医师，主要从事结直肠癌的诊治研究。 liyi7215098@163.com

Infection and rejection after small intestine transplantation

Chen Yuan-chong   

  1. Department of General Surgery, Zhangjiakou Fifth Hospital, Zhangjiakou  075000, Hebei Province, China
  • Received:2011-10-20 Revised:2011-11-30 Online:2011-12-31 Published:2011-12-31
  • About author:Chen Yuan-chong, Associate chief physician, Department of General Surgery, Zhangjiakou Fifth Hospital, Zhangjiakou 075000, Hebei Province, China liyi7215098@163.com

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摘要：

背景：小肠移植在中国部分移植中心已有开展，取得很好的短期疗效，但并发症的存在仍然是决定手术成功的主要问题，有效的预防和提早治疗是小肠移植研究的关键。
目的：探讨小肠移植后感染、排斥反应发生的原因以及预防治疗措施。
方法：以“小肠移植；肝肠移植；排斥反应；免疫抑制；感染”为中文关键词，以“Small bowel transplantation; Liver bowel transplantation; Rejection; Immunosuppressive; Infection”为英文关键词，采用计算机检索CNKI和Medline数据库2000-01/2011-06有关小肠移植感染和排斥反应的相关文章，筛选纳入25篇文献进行评价。
结果与结论：小肠富含大量的淋巴组织，含有大量的免疫活性细胞，而且肠腔内存在大量微生物，移植后造成排斥反应和感染发生率很高。减少并发症发生的关键在于提高预防治疗，注意治疗时机的把握，同时监测细胞因子水平的变化可以预防小肠移植排斥反应的发生。        

关键词: 小肠移植, 肝肠移植, 排斥反应, 免疫抑制, 感染

Abstract:

BACKGROUND: Small intestine transplantation has been conducted in some transplantation centers of China and obtained favorable short-term effects. However, complications are critical for success of transplantation, and effective prevention and early treatment of complications are important for small intestine transplantation.
OBJECTIVE: To discuss causes for posttransplant infection and rejection and prevention measures.
METHODS: With key words “Small bowel transplantation; Liver bowel transplantation; Rejection; Immunosuppressive; Infection” in English and Chinese, a computer-based online search of Medline and CNKI was performed for articles related to infection and rejection after small intestine transplantation published between January 2000 and June 2011. A total of 25 articles were included.
RESULTS AND CONCLUSION: The small intestine contains abundant lymphatic tissues and a large number of immune competent cells. Moreover, there are a large amount of microorganisms in the enteric cavity, inducing high incidence of rejection and infection following transplantation. Reduction of complications is based on prevention and treatment time. Monitor of cytokines changes can prevent rejection following small intestine transplantation.

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