中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (46): 8714-8717.doi: 10.3969/j.issn.1673-8225.2011.46.039

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

软骨形成过程中的转化生长因子β2

杨  玥1，薛同圆1，田  京2   

  1. 1南方医科大学第二临床医学院，广东省广州市 510515
    2南方医科大学珠江医院骨科中心，广东省广州市 510282
  • 收稿日期:2011-08-24 修回日期:2011-10-15 出版日期:2011-11-12 发布日期:2011-11-12
  • 通讯作者: 田京，教授，硕士生导师，副主任医师，南方医科大学珠江医院骨科中心，广东省广州市 510282 Tian_jing6723@yahoo.com.cn
  • 作者简介:杨玥，1990年生，主要从事组织工程方面的研究。 yysunmoon522@hotmail.com

Role of transforming growth factor beta 2 in cartilage formation

Yang Yue1, Xue Tong-yuan1, Tian Jing2   

  1. 1Second Clinical Medical College of Southern Medical University, Guangzhou  510515, Guangdong Province, China
    2Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou  510282, Guangdong Province, China
  • Received:2011-08-24 Revised:2011-10-15 Online:2011-11-12 Published:2011-11-12
  • Contact: Tian Jing, Professor, Master's supervisor, Associate chief physician, Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China Tian_jing6723@yahoo.com.cn
  • About author:Yang Yue, Second Clinical Medical College of Southern Medical University, Guangzhou 510515, Guangdong Province, China yysunmoon522@hotmail.com

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摘要：

背景：转化生长因子β2是一族多肽类生长因子，具有多重生物学效应，对骨髓间充质干细胞增殖分化功能有一定促进作用，是调节骨髓间充质干细胞增殖和向软骨细胞方向分化的最主要因子之一。
目的：探讨转化生长因子β2 的分子结构特点及其在软骨形成方面的作用。
方法：应用计算机检索中国期刊全文数据CNKI、中国期刊全文数据维普中文科技期刊数据库(VIP)和PubMed数据库(1995-01/2011-08)与骨组织工程中转化生长因子β2 诱导软骨形成有关的文章，检索词分别为“转化生长因子β2；软骨细胞分化；骨组织工程”和“TGF-β2；cartilage formation；tissue engineering”。纳入所述内容与转化生长因子β2 分子结构特点，转化生长因子β2信号转导通路，软骨细胞的诱导性分化，软骨性疾病的生物性治疗进展有关。排除综述文献、重复研究、观点陈旧的文章。
结果与结论：初检得到302篇文献，排除262篇不符合标准的文献，共纳入40篇符合标准的文献。经分析得出转化生长因子β2通过促进骨髓间充质干细胞分化为软骨细胞促进软骨特异性基质如Ⅱ型胶原及蛋白多糖的合成，从而发挥软骨诱导作用。转化生长因子β2 与其他因子共同作用调节软骨细胞生长分化，使临床上永久性修复软骨组织缺损的治疗变为可能。

关键词: 转化生长因子&beta, 2, 骨髓间充质干细胞, 软骨细胞分化, 信号通路, 骨组织工程, 软骨诱导, 综述文献

Abstract:

BACKGROUND: Transforming growth factor β2 is a family of polypeptide growth factors with multiple biological effects. It plays a role in the proliferation and differentiation of mesenchymal stem cells. It is one of the most important regulation factors for the mesenchymal stem cell proliferation and differentiation into cartilage cells.
OBJECTIVE: To analyze the molecular structure of transforming growth factor β2 and its role in cartilage formation.
METHODS: An online search of CNKI, VIP and PubMed database was performed for relevant articles on transforming growth factor β2 and cartilage formation of bone tissue engineering published between January 1995 and August 2011, using key words of " TGF-β2; cartilage formation; tissue engineering" in Chinese and English, respectively. Articles on the induction of chondrocyte differentiation, treatment progress of cartilage diseases, molecular structure and signal transduction pathway of transforming growth factor β2 were included. Duplicated studies, antiquated standpoint or review literatures were excluded.
RESULTS AND CONCLUSION: A total of 302 articles were obtained in the initial search. According to inclusion criteria, 262 of them were excluded, 40 documents were finally selected. Analysis results show that transforming growth factor β2 can facilitate the synthesis of cartilage specific matrix, such as type II collagen and proteoglycan, by promoting the differentiation from mesenchymal stem cell to chondrocyte. Therefore, transforming growth factor β2 has an induction effect on cartilage. It regulates the proliferation and differentiation of chondrocyte with other growth factors, which makes it possible to permanently repair the cartilage defects in the clinic.

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