中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (43): 8046-8049.doi: 10.3969/j.issn.1673-8225.2011.43.017

• 骨与关节实验造模 experimental modeling of the bone and joint • 上一篇    下一篇

膝骨关节炎模型内侧副韧带的生物力学特性

金晓飞1，2，郭长青1，蒋昭霞1，刘福水1，3   

  1. 1北京中医药大学针灸推拿学院，北京市  100029
    2山西中医学院针灸推拿系，山西省太原市 030024
    3江西中医学院，江西省南昌市  330004
  • 收稿日期:2011-04-15 修回日期:2011-08-24 出版日期:2011-10-22 发布日期:2011-10-22
  • 通讯作者: 郭长青，教授，北京中医药大学针灸推拿学院，北京市100029
  • 作者简介:金晓飞★，男，1974年生，山西省夏县人，汉族，2004年湖北中医学院针灸专业毕业，硕士，讲师，主要从事针刀基础与临床的研究。 47355033@qq.com

Biomechanical characteristics of medial collateral ligaments in animal models of knee osteoarthritis

Jin Xiao-fei1, 2, Guo Chang-qing1, Jiang Zhao-xia1, Liu Fu-shui1, 3   

  1. 1Acupuncture and Moxibustion School, Beijing University of Chinese Medicine, Beijing  100029, China
    2Department of Acupuncture and Moxibustion, Shanxi University of Traditional Chinese Medicine, Taiyuan  030024, Shanxi Province, China
    3Jiangxi University of Traditional Chinese Medicine, Nanchang  330004, Jiangxi Province, China
  • Received:2011-04-15 Revised:2011-08-24 Online:2011-10-22 Published:2011-10-22
  • Contact: Guo Chang-qing, Professor, Acupuncture and Moxibustion School, Beijing University of Chinese Medicine, Beijing 100029, China
  • About author:Jin Xiao-fei★, Master, Lecturer, Acupuncture and Moxibustion School, Beijing University of Chinese Medicine, Beijing 100029, China; Department of Acupuncture and Moxibustion, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China 47355033@qq.com

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527

被引次数

44

摘要：

背景：膝骨关节炎多由力学和理化因素导致软骨基质退变而引起。目前对发病的理化因素和软骨基质的退变研究较多，力学研究较少。
目的：观察兔膝骨关节炎模型内侧副韧带拉伸力学性质的改变。
方法：左后肢伸直位石膏固定制动法建立兔模型。在Bose Electro Force 3300疲劳试验机上对正常对照组和模型组各6个试样进行拉伸实验。拉伸实验的速度为5 mm/min，计算机每0.1 s自动记录一个数据，直到将试样拉断。
结果与结论：正常对照组最大应力为(17.92±3.18) MPa，最大应变为(10.7±2.07)%，最大位移为(2.76±0.37) mm，弹性模量(316.19±74.55) MPa；模型组最大应力为(11.34±1.05) MPa，最大应变为(7.97±1.65)%，最大位移为(2.08±0.31) mm，弹性模量(279.77±33.91) MPa。正常对照组各项拉伸性能指标显著大于模型组(P < 0.05)。提示膝骨关节炎对膝关节韧带的生物力学特性具有一定影响。

关键词: 膝骨关节炎, 模型, 内侧副韧带, 拉伸, 生物力学

Abstract:

BACKGROUND: Factors of mechanics and physical chemistry lead to degeneration of cartilage matrix which may cause knee osteoarthritis (KOA). There are lot of studies on factors of physical chemistry and degeneration of cartilage matrix and few studies on factors of mechanics.
OBJECTIVE: To explore the change of tension for medial collateral ligament (MCL) of rabbit KOA models.
METHODS: Rabbits in the model group were copied into KOA models, after which test on tension was performed to each of the 6 rabbits in the two groups at the speed of 5 mm/min on Bose Electro Force 3300 protracted test machine. Data obtained from the test every 0.1 s were recorded as far as the sample was pulled and broken.
RESULTS AND CONCLUSION: Maximum displacement, maximum stress, maximum strain and modulus of elasticity of MCL were (2.76±0.37) mm, (17.92±3.18) MPa, (10.7±2.07)%, (316.19±74.55) MPa in the normal control group and (2.08±0.31) mm, (11.34±1.05) MPa, (7.97±1.65)%, (279.77±33.91) MPa in the model group. We could see that each index in the normal control group was greater than that in the model group obviously (P < 0.05). It indicates that KOA has a certain effect on the biomechanics of MCL.

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