中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (42): 7902-7906.doi: 10.3969/j.issn.1673-8225.2011.42.027

• 生物材料综述 biomaterial review • 上一篇    下一篇

组织工程化口腔黏膜构建的研究现状

胡  丽，刘加荣，陈莉莉   

  1. 华中科技大学同济医学院附属协和医院口腔科，湖北省武汉市430022
  • 收稿日期:2011-06-28 修回日期:2011-08-05 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 陈莉莉，主任医师，华中科技大学同济医学院附属协和医院口腔科，湖北省武汉市 430022 lily-c1030@ 163.com
  • 作者简介:胡丽☆，女，1986年生，湖北省潜江市人，汉族，华中科技大学同济医学院附属协和医院在读博士，主要从事组织工程研究。 mygirlhl@ 163.com
  • 基金资助:

    国家自然科学基金项目(30970740)：人工复合式口腔牙龈黏膜的构建及抗感染研究；湖北省卫生厅科研课题(JX4B10)：体外增强复合式口腔黏膜抗菌蛋白编码基因的表达。

Research progress on construction of tissue engineered oral mucosa

Hu Li, Liu Jia-rong, Chen Li-li   

  1. Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan  430022, Hubei Province, China
  • Received:2011-06-28 Revised:2011-08-05 Online:2011-10-15 Published:2011-10-15
  • Contact: Chen Li-li, chief physician, Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China Lily-c1030@163.com
  • About author:Hu Li☆, Studying for doctorate, Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China mygirlhl@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30970740*; a grant from Hubei Provincial Health Department, No. JX4B10*

PDF

343

被引次数

6

摘要：

背景：口腔黏膜组织工程期待能解决自体黏膜修复组织来源不足的难题。
目的：综述组织工程化口腔黏膜的种子细胞的来源及选择、各种常见支架材料的优缺点及相关生长因子的研究进展。
方法：由第一作者以“tissue engineering of oral mucosa, seed cells, scaffold  material, growth factor”为检索词，检索PubMed数据库及Elsevier数据库2000-01/2011-12有关文章。
结果与结论：几种常见的口腔黏膜组织工程种子细胞在研究中都有较好的增殖或分化能力，脂肪干细胞与其他种子细胞相比具有更明显的优势，可作为一种较理想的种子细胞；各种常见的支架材料都有各自的优缺点，可以采用多种方式改善其性能；将一些关键的细胞因子运用到口腔黏膜组织工程中，能促进移植物血管化，加快伤口愈合过程。口腔黏膜组织工程将是在临床上能解决异体移植免疫排斥及传播疾病和自体黏膜修复组织来源不足等问题一种安全有效的修复方法。

关键词: 组织工程化口腔黏膜, 种子细胞, 支架, 生长因子, 综述文献

Abstract:

BACKGROUND: Tissue engineering of oral mucosa has been developed rapidly in the recent decades, looking forward to overcome increasing requirement of oral mucosa reconstruction and supply shortage.
OBJECTIVE: To review the critical process of origin and choice of seed cells, scaffold materials and their advantages or disadvantages, and related growth factors in tissue engineered oral mucosa construction.
METHODS: Databases of PubMed and Elsevier were retrieved by the first author to research the papers published 2000-01/2011-12 by using “tissue engineering of oral mucosa, seed cells, scaffold material, growth factor” as keywords.
RESULTS AND CONCLUSION: Several familiar seed cells of oral mucosa tissue engineering have good proliferation or differentiation capacity. Adipose-derived stem cells, which have more advantages compared to other seed cells, can be a kind of ideal seed cells. Multifarious common scaffold materials have their own advantages and disadvantages, and various methods can be applied to improve their properties. Application of some critical cytokines in oral mucosa tissue engineering can promote angiogenesis of implants and accelerate wound healing. Tissue engineering of oral mucosa is a safe and effective repairing method which can solve immunologic rejection and disease transmission of allograft and insufficient supply of autologous oral mucosa graft, and needs to be further researched.

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