中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (37): 7013-7016.doi: 10.3969/j.issn.1673-8225.2011.37.041

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

受体的适应性变化及细胞信号转导规律与运动的联系

李宏伟1，狄朝晖2   

  1. 1赣南师范学院体育学院，江西省赣州市  341000
    2赣南师范学院校医院，江西省赣州市  341000
  • 收稿日期:2011-04-06 修回日期:2011-07-16 出版日期:2011-09-10 发布日期:2011-09-10
  • 通讯作者: 李宏伟☆，男，1969年生，辽宁省抚顺市人，汉族， 2009年上海体育学院院毕业，博士，副教授，主要从事运动医学的研究。 lihongwei1969@126.com
  • 作者简介:李宏伟☆，男，1969年生，辽宁省抚顺市人，汉族， 2009年上海体育学院院毕业，博士，副教授，主要从事运动医学的研究。 lihongwei1969@126.com

Association of receptor adaptative change and cell signal transduction with exercise

Li Hong-wei1, Di Zhao-hui2   

  1. 1School of Sports, Gannan Normal University, Ganzhou  341000, Jiangxi Province, China
    2Hospital of Ganzhou Normal University, Ganzhou  341000, Jiangxi Province, China
  • Received:2011-04-06 Revised:2011-07-16 Online:2011-09-10 Published:2011-09-10
  • Contact: Li Hong-wei, Doctor, Associate professor, School of Sports, Gannan Normal University, Ganzhou 341000, Jiangxi Province, China lihongwei1969@ 126.com
  • About author:Li Hong-wei☆, School of Sports, Gannan Normal University, Ganzhou 341000, Jiangxi Province, China

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摘要：

背景：受体调控和转换信号并启动细胞内信号转导，使靶细胞产生生物学效应。受体调节是机体对运动适应的重要调节方式。
目的：总结运动对受体的影响、受体的适应性变化及运动受体细胞信号转导规律。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：2000/2010)和Medline数据库(2000/2010)，检索词分别为“受体，运动，适应”和“receptor regulation，exercise，adaption”。共检索到137篇文章，按纳入和排除标准对文献进行筛选，共纳入37篇文章。从受体概念、受体的分类和功能，受体的功能与调节，运动对受体的影响等方面进行总结，对受体在运动中的适应性变化和调节机制等方面进行探讨。
结果与结论：运动训练引起瘦素受体和胰岛素受体上调，使瘦素和胰岛素分泌发生适应性改变。适宜运动使雄激素受体结合容量和受体数量提高，长期大运动量训练和力竭使雄激素受体结合容量和受体数量下降，意味着保护细胞免受过量或长期刺激而导致生理功能紊乱。急性应激使机体各组织中糖皮质激素受体含量减少，对于防止物质代谢和能量代谢紊乱，维持机体内环境稳定有重要意义。

关键词: 运动, 受体, 调节, 适应, 细胞信号转导, 组织工程

Abstract:

BACKGROUND: The receptor regulates and switches signal and starts intracellular signal transduction, which causes target cells to produce biological effects. Receptor regulation is an important regulation mode for organism to motor adaptation.
OBJECTIVE: To summarize the effects of motor on receptor, the adaptative change of receptor, and signal transduction rule of motor receptor cells. 
METHODS: A computer-based retrieval was performed by the first author to search manuscripts in the CNKI (2000/2010) and Medline database (2000/2010) with the key word “receptor regulation, exercise, adaption”. A total of 137 manuscripts were included. According to inclusion and exclusion criteria, totally 37 manuscripts were included in the final analysis. The included manuscripts were summarized in terms of receptor concept, receptor classification and function, receptor function and regulation, the effects of motor on receptor, and adaptative change of receptor in exercise, as well as the regulation mechanism of receptor.
RESULTS AND CONCLUSION: Exercise could up regulate leptin receptor and insulin receptor, leading to adaptative change of androgen and insulin secretion. Proper exercise increased androgen receptor binding capacity and receptor numbers. Long-term high-intensity or exhaustive exercise decreased androgen receptor binding capacity and receptor numbers, which protect cells from excessive or long-term stimulation-caused physiological dysfunction. Acute stress reduced glucocorticoid receptor level in each tissue organs, and showed important significance for preventing from substance metabolism and energy metabolism disturbance and maintaining homoeostasis.

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