中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (37): 6995-6999.doi: 10.3969/j.issn.1673-8225.2011.37.037

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

软骨下骨病理骨重建过程中骨细胞的代谢机制

杜明昌1，祖启明2，刘宪民2，刘松波2，陈  语2，王  琪2，项良碧2   

  1. 解放军沈阳军区总医院，1博士后科研工作站，2骨科，辽宁省沈阳市  100016
  • 收稿日期:2011-03-05 修回日期:2011-04-06 出版日期:2011-09-10 发布日期:2011-09-10
  • 通讯作者: 刘宪民，硕士研究生导师，教授，解放军沈阳军区总医院骨科，辽宁省沈阳市 100016 surgeon_du@ 163.com
  • 作者简介:杜明昌☆，博士，主要从事骨科方面的研究。 surgeon_du@yahoo.cn

Osteocyte metabolism during reconstruction of subchondral bone

Du Ming-chang1, Zu Qi-ming2, Liu Xian-min2, Liu Song-bo2, Chen Yu2, Wang Qi2, Xiang Liang-bi2   

  1. 1Postdoctoral Scientific Research Workstation, 2Department of Orthopedics, Shenyang Military Area Command of Chinese PLA, Shenyang  100016, Liaoning Province, China
  • Received:2011-03-05 Revised:2011-04-06 Online:2011-09-10 Published:2011-09-10
  • Contact: Liu Xian-min, Master’s Supervisor, Professor Department of Orthopedics, Shenyang Military Area Command of Chinese PLA, Shenyang 100016, Liaoning Province, China supervisor Professor, Surgeon_du@ 163.com
  • About author:Du Ming-chang☆, Doctor, Postdoctoral Scientific Research Workstation, Shenyang Military Area Command of Chinese PLA, Shenyang 100016, Liaoning Province, China surgeon_du@ yahoo.cn

PDF

372

被引次数

6

摘要：

背景：骨性关节炎一直被认为是关节软骨的退变和降解。现已逐步认识到软骨下骨结构及分子代谢的病理变化在关节退变的过程中发挥了重要的作用。
目的：观察软骨下骨在骨性关节炎进程中结构及细胞、相关因子和信号通道的变化，分析软骨下骨的病理改变对关节软骨退变的影响。
方法：使用骨性关节炎、软骨下骨、软骨退变、骨重建、骨代谢等关键词，检索中国知识资源总库与PubMed、Medline、Embase数据库中的相关研究论文，了解骨性关节炎进程中软骨下骨骨代谢平衡破坏后在结构及分子信号机制的病理变化，分析这些病理改变与关节软骨退变的关系。
结果与结论：纳入 54篇符合标准的文献。软骨下骨的病理骨重建贯穿骨性关节炎的始终，局部骨细胞的代谢及干细胞分化异常与软骨退变相互影响。通过对软骨下骨病理骨重建过程中骨细胞代谢机制的深入了解，为骨性关节炎提供了新的治疗靶点。

关键词: 软骨下骨, 骨性关节炎, 骨重建, 骨代谢, 软骨退变

Abstract:

BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disorder of a high prevalence that remains the leading cause of disability in aged people. Although articular cartilage breakdown is a major characteristic of OA, several tissues of the joint, including the subchondral bone, play significant roles in the development/progression of OA pathology.
OBJECTIVE: To investigate the changes in structure, osteocyte, related factors and signal pathway of subchondral bone during the development/progression of OA pathology, and analyze the effects of pathological changes of subchondral bone on degeneration of articular cartilage.
METHODS: A computer-based retrieval was performed to research papers in CNKI, PubMed, Medline, Embase databases with the key words “osteoarthritis, subchondral bone, cartilage degeneration, bone reconstruction, and bone metabolism.”The pathological changes of subchondral bone structure and molecular signaling mechanism after destructing bone metabolic equilibrium during the development/progression of OA pathology were analyzed.
RESULTS AND CONCLUSION: According to inclusion criteria, 54 papers were included. Subchondral bone reconstruction progresses throughout the entire process of OA. Metabolism of local osteocytes and abnormal differentiation of stem cells influence cartilage degeneration mutually. Further understanding of the mechanism underlying osteocyte metabolism during the process of subchondral bone reconstruction can provide a new therapeutic target for OA.

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