中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (35): 6602-6606.doi: 10.3969/j.issn.1673-8225.2011.35.034

• 骨与关节综述 bone and joint review • 上一篇    下一篇

细胞移植及髓核组织工程重建修复椎间盘退变

陈清河，叶君健   

  1. 福建医科大学附属第一医院骨科，福建省福州市350005
  • 收稿日期:2011-04-19 修回日期:2011-05-23 出版日期:2011-08-27 发布日期:2011-08-27
  • 通讯作者: 叶君健，教授，福建医科大学附属第一医院骨科， 福建省福州市350005 yejunjian@medmail.com.cn
  • 作者简介:陈清河★，男，1981年生，福建省厦门市人，汉族，福建医科大学在读硕士，主要从事腰椎间盘退变的基础研究与临床研究。 johny_chan@yahoo.cn
  • 基金资助:

    福建省自然基金资助项目(c710010)；福建省教授学术发展基金项目(js9007)。

Cell transplantation and tissue engineering reconstruction of nucleus pulposus in the treatment of intervertebral disc degeneration 

Chen Qing-he, Ye Jun-jian   

  1. Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou  350005, Fujian Province, China
  • Received:2011-04-19 Revised:2011-05-23 Online:2011-08-27 Published:2011-08-27
  • Contact: Ye Jun-jian, Professor, Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China yejunjian@medmail.com.cn
  • About author:Chen Qing-he★, Studying for master’s degree, Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China johny_chan@yahoo.cn
  • Supported by:

    the Matural Science Foundation of Fujian Province, No.c710010*; Academic Development Fund for Professors in Fujian Province, No.js9007*

PDF

402

被引次数

10

摘要：

背景：通过细胞组织工程将细胞或细胞支架复合体植入退变缺损的椎间盘内，使退变的椎间盘再生可能是治疗椎间盘退变性疾病最为理想的方法。
目的：评价组织工程髓核体内移植抑制腰椎间盘退变的临床疗效及应用前景。
方法：由第一作者检索1990/2010 PubMed数据、中国知网及万方数据库有关组织工程髓核、组织工程材料及骨髓间充质干细胞治疗腰椎间盘退变方面的文献。
结果与结论：目前常用的细胞支架主要包括胶原支架、琼脂糖支架、藻酸盐支架、聚乙醇酸支架与壳聚糖支架以及复合材料等。通过自体椎间盘细胞或间充质干细胞结合基因技术筛选种子细胞，进行细胞和/或细胞支架复合体移植恢复或再生相关细胞外基质的合成，通过逆转和修复椎间盘细胞病理性改变，为退变的椎间盘组织和功能恢复提供了全新的治疗策略。

关键词: 椎间盘退行性变, 细胞移植, 髓核细胞, 间充质干细胞, 细胞支架, 椎间盘重建 

Abstract:

BACKGROUND: It is the best ideal therapy for degenerative disc diseases to implant cells or cell scaffold complex into the degenerated disc so as to improve the regeneration of the intervertebral disc.
OBJECTIVE: To evaluate the clinical effect and prospect of in vivo transplantation of nucleus pulposus cells for degenerative disc diseases.
METHODS: The first author retrieved PubMed, CNKI, and Wanfang databases for articles about tissue engineering nucleus pulposus, tissue engineering materials and bone marrow mesenchymal stem cells for treatment of degenerative disc diseases published from 1990 to 2010.
RESULTS AND CONCLUSION: The common scaffolds include collagen scaffold, agarose scaffold, alginate scaffold, polyglycolic acid scaffold, chitosan scaffold and composite scaffold. By gene screening technique, the seed cells were selected from autologous disc cells or mesenchymal stem cells. Then, the cells and/or cell scaffold complex transplantation was for synthesis of regenerated extracellular matrix. It provides a new therapeutic strategy for functional recovery of degenerated disc through the reversal and restoration of intervertebral disc cells.

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